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Biomedical subjects

M Plankey

Publications and source records attributed to M Plankey.

4 recordsLinked to original sources
PubMed2002

Differential associations of body mass index and adiposity with all-cause mortality among men in the first and second National Health and Nutrition Examination Surveys (NHANES I and NHANES II) follow-up studies.

OBJECTIVE: The frequently observed U-shaped relationship between body mass index (BMI; kg/m(2)) and mortality rate may be due to the opposing effects of fat mass (FM) and fat-free mass (FFM) components of BMI on mortality rate. The purpose is to test the hypothesis stated above. DESIGN: Longitudinal prospective cohort studies. The mortality follow-up of the first and second National Health and Nutrition Examination Surveys (NHANES I and NHANES II). SUBJECTS: A total of 10 169 male subjects aged 25-75 who participated in NHANES I and II were selected for analyses. Follow-up continued until 1992. The mean follow-up time was 14.6 y for NHANES I and 12.9 y for NHANES II. Ninety-eight percent of the participants were successfully followed representing a total of 3722 deaths. MEASUREMENTS: Subscapular and triceps skinfolds thickness were used as FM indicators, whereas upper arm circumference was used as a FFM indicator. The Cox proportional hazards model tested the relationships of BMI, FM and FFM with all-cause mortality adjusting for age, smoking status, race and education levels. RESULTS: BMI had a U-shaped relationship with mortality, with a nadir of approximately 27 kg/m(2). However, when indicators of FM and FFM were added to the model, the relationship between BMI and mortality became more nearly monotonic increasing. Moreover, the relationship between FM indicator and mortality was monotonic increasing and the relationship between FFM indicator and mortality was monotonic decreasing. CONCLUSION: These results support the hypothesis that the apparently deleterious effects of marked thinness may be due to low FFM and that, over the observed range of the data, marked leanness (as opposed to thinness) has beneficial effects.

Adipose Tissue↗
PubMed1988

Left ventricular function in ischemic mitral regurgitation--a precatheterization assessment.

The clinical characteristics of 150 patients with unstable ischemic heart disease were evaluated for the ability to diagnose mitral regurgitation (MR). A careful assessment of physical findings, ECG- and radionuclide-determined global and regional left ventricular function was performed in all patients to characterize the population with ischemic MR. Twenty-nine patients were found to have MR and in 65% the degree of MR was 2+ or more. All of the patients with significant MR had a systolic murmur on physical examination, and although this finding was 90% sensitive for MR it had a poor predictive value (42%). Even a characteristic apical holosystolic murmur, although specific for MR (90%), had a low sensitivity and predictive value. Two regional wall motion abnormalities (inferoposterior akinesis and apical dyskinesis with an ejection fraction less than or equal to 35%) identified 26 of 29 patients with MR and all with 2+ or more MR, as well as the 10 patients who required mitral valve replacement in addition to coronary artery bypass grafting. This finding was complementary to the results of physical examination and when used together improved the diagnostic accuracy of identifying MR. The radionuclide regurgitant index was evaluated for its predictive value in assessing MR in this group of patients but was found to be a poor discriminator in patients with abnormal ejection fractions and regional wall motion abnormalities. The precatheterization assessment of left ventricular function with radionuclide angiography can provide important insight into the presence of ischemic MR.

Adult↗
PubMed1984

Functional left ventricular aneurysm formation after acute anterior transmural myocardial infarction. Incidence, natural history, and prognostic implications.

To assess the clinical and prognostic importance of the early appearance of a functional left ventricular aneurysm after myocardial infarction, we used equilibrium radionuclide angiocardiography to study 51 patients with an initial anterior infarction. A functional aneurysm was defined as an area of systolic akinesis or dyskinesis with a distinct diastolic deformity and preserved adjacent wall motion. Functional aneurysms developed in 18 patients (Group 1). Left ventricular ejection fraction was comparable in this group and in the 33 patients without aneurysm (Group 2) (27.3 +/- 10 vs. 31.4 +/- 12 per cent). One-year mortality was markedly different, with 11 deaths (61 per cent) in Group 1 and 3 (9 per cent) in Group 2 (P less than 0.001). Six (55 per cent) of the deaths in Group 1 were sudden. Patients with a functional aneurysm appearing within 48 hours had the highest risk of dying (8 of 10). Thus, early formation of a functional aneurysm occurs frequently after anterior myocardial infarction and carries a high risk of death within one year that is independent of ejection fraction. In addition, the absence of a functional aneurysm identifies a large group with a low one-year mortality despite a markedly impaired ejection fraction.

Creatine Kinase↗