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Biomedical subjects

M Plchová

Publications and source records attributed to M Plchová.

6 recordsLinked to original sources
PubMed1992

[Malignant transformation in multiple eccrine spiradenoma].

Development of a poorly differentiated eccrine carcinoma was observed in a 6-year-old woman. She had been operated on many times during 20 years for some tens of classical as well as less usual forms of eccrine spiradenomas, e.g. giant vascular spiradenomas. They were mostly localized in the skin of back, thorax and neck. The patient died of an extensive skin involvement and spine and liver secondaries 12 months after occurrence of the carcinoma. The structure of carcinoma was trabecular and partly papillary, tumour cells had bulky nuclei and striking nucleoli. There was a juxtaposition of spiradenomas with carcinoma and direct transformation of spiradenoma into carcinoma was observed. Immunohistological positivity of carcinoma concerned S-100 protein, slightly CEA, focally cytokeratin 7 and 18; cytokeratin 14 was negative. Ultrastructure of tumour cells showed irregular intercellular lumina with some microvilli, but structures characteristical for eccrine glandular of ductal differentiation were lacking.

Adenoma, Sweat Gland↗
PubMed1989

[Congenital neuroblastomas].

A group of 2,576 autopsies of children of the age of 0 to 15 years (made between 1978 and 1987) comprised 14 congenital (neonatal) tumours (among 93 tumorous lesions). Teratomas were the most frequent congenital tumours followed by neuroblastomas (4 and 3 cases). Neuroblastomas grew from cervical and thoracoabdominal sympathicus and from the right adrenal medulla. The most frequent and most extent hematogenic dissemination concerned liver, microscopical examination found dissemination in various organs as well as a lymphatic spread to regional lymph nodes (in 2 cases). One case was characterized by an exclusive continual destructive growth in retroperitoneum and posterior mediastinum with 2 macroscopical secondaries in skeleton. Pathognomic differentiated structures were always found by light microscopy. Differential diagnosis of round cell tumours of infancy was discussed with a concise exposure of symptomatology and autoptic findings of neuroblastomas according to congenital cases from literature.

Adolescent↗
PubMed1985

[Tumors of the thyroid gland in childhood--study of biopsy material].

A group of 29 biopsies from resected thyroid gland was represented by 5 boys and 24 girls of the age under 15 years; the mean age was 12,7 years. There were 7 cases of colloid adenoma, 5 of follicular adenoma, 5 of atypical adenoma and 5 of papillary carcinoma among them. A basedowian goiter was verified in 4 cases, Hashimoto-type thyroiditis was found once, thyroid gland was lacking twice. A shift between clinical and pathomorphological diagnoses was remarkable.

Adenoma↗