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Biomedical subjects

M Pokorná

Publications and source records attributed to M Pokorná.

At least 19 recordsLinked to original sources

[Bone surgery for unstable hips in patients with cerebral palsy].

PURPOSE OF THE STUDY: The aim of this retrospective study was to compare the efficacy of femoral osteotomy alone with that of osteotomy combined with an acetabular procedure in patients with unstable hips due to spastic cerebral palsy. MATERIAL: Sixty-one hip joints in 50 patients who had shown distinct subluxation or dislocation of the joint were operated on. Eleven patients underwent bilateral surgery. Before bone surgery, soft-tissue release involving both the flexors and adductors was performed on 19 hips. Femoral osteotomy alone was performed on 29 hip joints and combined femoral and pelvic osteotomy was carried out on 32 joints.Twelve resections of the proximal femur in seven patients were evaluated as a separate group. All treated hip joints were assessed by clinical and radiographic examination at a follow-up of more than 5 years. METHODS: The skiagraphs taken in a strictly neutral position of the lower limbs before surgery and at the final examination were evaluated on the basis of Reimers's migration index and Wiberg's centre-edge angle. The locomotor abilities of each child were categorized according to the Vojta scoring system for locomotor development. The range of motion in the treated hip joint was assessed using the standard S. F. T. R. method. The results obtained were statistically analyzed by the Kruskal- Wallis, one-way ANOVA test. RESULTS: A comparison of the results of femoral osteotomy alone with those of combined femoral and pelvic osteotomy showed that the post-operative values of the migration index and centre-edge angle, as compared with the pre-operative ones, were statistically higher (p<0.05) in the latter. In a long-term perspective, the surgery had no adverse effects on a natural development of locomotor abilities of the child. The children had higher scores by the modified Vojta rating system. There was no change in the range of motion in the treated hip joints after the operation. DISCUSSION: In 28, out of the 32 joints treated by combined femoral and pelvic osteotomy, Salter osteotomy was performed and it showed a high efficacy in providing hip joint stability. The main emphasis during surgery was placed on the maximum acetabular rotation laterally. Femoral osteotomy alone was less effective in providing hip joint stability; in addition, in order to achieve this, tilting of the proximal fragment to a varus position was generally higher than in combined operations. In three patients this treatment resulted in fixed adduction of the hip joint with negative consequences for movement. CONCLUSIONS: In the treatment of unstable hip joints a combination of varus derotation femoral osteotomy and pelvic osteotomy provides better containment of the joint than femoral osteotomy alone.

Acetabulum↗

[Percutaneous aponeurotomy of the triceps surae muscle in cerebral palsy in children].

PURPOSE OF THE STUDY: To assess the short-term results of percutaneous aponeurotomy of gastrocnemius including the possible complications and effects of the treatment. MATERIAL: Totally 88 procedures were performed in 61 patients in the period 1998-2001. Re-examination in 2002 involved 44 patients with 66 procedures. METHODS: The procedure was done from one-point incision. Six weeks immobilisation followed. Re-examination concerned the shape of the calf, the testing for palpable defect, US examination of calf muscles and aponeurosis, neurological and vascular examination. RESULTS: Recurrence of mild degree of equinus deformity was found in 3 out from 66 procedures. No neurological or vascular complications were registered. DISCUSSION: Rate of recurrence in this study is comparable with the figures after open aponeurotomy. CONCLUSION: Operation is reserved for skilled surgeon, however in short future, most of operations on spastics will be done like video-assisted procedures.

Cerebral Palsy↗

[Light microscopic studies of pulp morphology following orthodontic therapy].

The authors studied the dental pulp morphology and distribution of acid and neutral mucopolysaccharides in teeth subjected to orthodontic therapy. The teeth were moved with a fixed appliance using forces of 60-200 g. Changes in the histological structure of the dental pulp followed the therapy. The number of collagen fibres increased; they were densely packed and formed thick bundles. A certain degree of hyalinization was also observed. The dental pulp cavity was narrowed by apposition of hard tissue deposits along the canal wall. Pulp stones and diffuse calcification were often encountered. The reaction of acid mucopolysaccharides was found to be very weak, sometimes even negative. The reaction of neutral mucopolysaccharides was not affected so markedly. The results of the paper suggest that changes induced in the dental pulp with fixed orthodontic appliances are irreversible and correspond to those of aging. These premature changes together with rapid hard tissue formation, may negatively influence endodontic treatment in the future.

Child↗

[Serological study of a breed of broilers with edema disease].

Twenty selected groups of chickens (835 birds on the whole) coming from randomly chosen broiler production cycles were studied for the occurrence of precipitation antibodies to the viruses of Marek's disease, infectious bronchitis, Newcastle disease, infectious bursitis, reovirus, Tipton virus and CELO. The occurrence of these antibodies was subjected to statistical evaluation and to comparison with the occurrence rate of oedema disease in the tested broiler production cycles (296 166 birds on the whole). Neither correlations nor synergistic effect was observed between the studied virus infections and the occurrence of oedema disease. Serological research demonstrated a high rate of the occurrence of reovirus. (positive proportion: 26% of samples and 100% of groups), infectious bursitis virus (56.8% and 75%) and Tipton virus (74.5% and 100%) in broilers.

Animals↗

[Microbiological purity of pharmaceutical preparation. Part 1: External remedies; and effects of type of cream, container, storage, temperature and application (author's transl)].

A fractional factorial experiment of the 2n type was carried out, to follow the effects of eight factors affecting simultaneously the microbiological purity of creams (Oleocremor leniens, Hydrocremor stearini) during the manufacturer-consumer chain. The effects of these factors (antibacterial substances, container (collapsible tube, pot), type of cream, storage (open, closed), number of takeouts, manner of taking-out (spatula, finger), temperature of storage, consumer (dermatological clinic, household) and interactive and interdependent. The microbiological purity of the creams is mostly impaired by the number of take-outs and the manner of taking-out. Collapsible tubes and, perhaps even better, one-dose packings are considered a solution of this problem. It is recommended to investigate creams individually with reference to their composition and structure, contents of antibacterial substances, technology and application. The tentative specification for the microbiological purity criteria of ointments and creams, designed for the Czechoslovak Pharmacopoeia, 4th Edition, is acceptable.

Administration, Topical↗

Deletion of long arms of chromosome 13.

The case is presented of a girl with the banded karyotype 46,XX,del(13)(q22) and a phenotype of severe mental and growth deficiency, mongoloid slant of palpebral fissures, ptosis, hypertelorism, microcephaly, microstomia, micrognathia, nystagmus, gothic palate, uvula fissa, low-set malformed ears, short fingers, pedes excavati, dislocation of hips and diabetes insipidis. Both parents have a normal phenotype and karyotype.

Abnormalities, Multiple↗