Biomedical subjects

M Pollay

Publications and source records attributed to M Pollay.

At least 55 records · Page 3Linked to original sources

PubMed1975

Effect of hypertonic solutions on the blood-brain barrier.

The effect of hypertonic urea and saline on the blood-brain barrier of the dog was quantitatively measured by the indicator diffusion technique. Urea appeared to stimulate glucose transport into the brain, while the diffusionary loss of fructose was enhanced. Hypertonic saline affected the diffusionary loss of the test sugars in a similar manner, but had no effect on glucose transport. The blood-brain barrier alterations were not reversible, but did decrease somewhat with time.

Animals↗

PubMed1975

Formation of cerebrospinal fluid. Relation of studies of isolated choroid plexus to the standing gradient hypothesis.

After a brief summary of current views on the origin of cerebrospinal fluid (CSF) and the processes underlying its elaboration, the author discusses studies of isolated choroid plexus in extracorporeal perfusion systems and flux chambers. The results suggest that transependymal water flow is secondary to the electrically silent pumping of sodium. The author presents evidence in support of the standing gradient hypothesis as the structural basis of CSF secretion.

Adult↗

PubMed1975

Evaluation of altered blood-brain barrier permeability to amino acids.

The blood-brain barrier (BBB) in one cerebral hemisphere of rabbit was damaged by the ipsilateral infusion of hypertonic (3 Molar) urea into the carotid artery. Using the indicator diffusion technique, the clearance of the glycine (by simple diffusion) and phenylalanine molecule (by facilitated diffusion) was enhanced in the urea infused cerebral hemisphere. The experimental methodology is a nondestructive and sensitive method for evaluating the integrity of the BBB.

Amino Acids↗

PubMed1974