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Biomedical subjects

M Poloni

Publications and source records attributed to M Poloni.

At least 55 records · Page 3Linked to original sources
PubMed1982

EEG findings in 118 cases of myasthenia gravis.

We examined 148 EEG recordings from 118 patients affected with myasthenia gravis (35 males and 83 females, aged 17-82, with illness durations between 1 month and 24 years). The cases were clinically evaluated according to Ossermann's classification at the time of EEG recording. EEG patterns were subdivided into normal, diffuse or focal slow abnormalities, or epileptiform patterns. Of the 118 patients, 104 had normal EEG recordings and 14 had at least one abnormal recording (8 diffuse slow abnormalities, 6 focal slow abnormalities). The EEG findings were not correlated with clinical parameters (thymic pathology, respiratory incidents, drug treatment, etc.). One patient (whose EEG recordings were normal) showed an isolated epileptic fit and another patient was affected by epilepsy. A possible relationship between the two diseases is discussed.

Adolescent↗
PubMed1982

Isoprinosine in multiple sclerosis treatment: a preliminary study.

Isoprinosine, a drug enhancing the cellular immunity, was administered to 11 patients with multiple sclerosis (MS) for a period of 60 days. Kurtzke's Disability Status Scale was evaluated in all the patients before the starting of the therapy and after 60 days and after 14 months of follow-up. 11 MS patients were taken as a control group and were treated with prednisone for the same period of time. No significant difference in the clinical course of the disease between the two groups of patients after the therapeutical trial was observed. CSF examination showed IgG oligoclonal bands in all the cases; no modification of the CSF IgG profile was found after the therapy in those patients in whom the lumbar puncture was performed after the follow-up period.

Adult↗
PubMed1982

Chronic progressive external ophthalmoplegia. Clinical, electrophysiological, histochemical and ultrastructural studies of 14 cases.

Clinical, histochemical and ultrastructural findings concerning 14 cases with diagnosis of Chronic Progressive External Ophthalmoplegia are described. According to the clinical features the patients have been rated in two groups: the first including subjects with isolated ptosis or ptosis with external ophthalmoplegia and the second including subjects with a spreading of the muscular deficit and involvement of the neck and limbs. The most frequent histological and histochemical features are type I fibre atrophy, ragged-red fibres, DPNH-diaphorase reaction disorders and abnormal accumulation of lipids into the fibres. Electron microscopy reveal myofibrillar disorganization and clusters of polymorphous, abnormal mitochondria. In five cases mitochondria contain a variety of crystalline inclusions. Correlations between clinical data and histochemical and ultrastructural findings are discussed. Mitochondrial abnormalities are postulated to be a characteristic physiopathological pattern in CPEO.

Adult↗
PubMed1982

Neuromuscular diseases associated with benign monoclonal gammopathy. Study of CSF and serum proteins by isoelectric focusing.

In over 1200 cases examined by isoelectric focusing of CSF and serum proteins, 4 patients had benign monoclonal gammopathy. These patients were affected by amyotrophic lateral sclerosis of bulbar onset, sensitive neuropathy of Thevenard type, myasthenia gravis, and limb-girdle muscular dystrophy, respectively. The difficulty to relate the differences in the clinical features of these cases to a common physiopathological mechanism and the incidence of this finding (0.4% in 873 cases ranging from 21-60 years of age) do not seem to suggest any pathogenetic relationship between benign monoclonal gammopathy and the different neurological disorders encountered in these patients.

Adult↗
PubMed1981

Identification of the kappa and lambda light chains within the CSF immunoglobulin region in multiple sclerosis and subacute sclerosing panencephalitis by immunofixation after isoelectric focusing.

The distribution of the kappa and lambda light chains within the cerebrospinal fluid (CSF) IgG oligoclonal bands of 15 multiple sclerosis (MS) and 3 subacute sclerosing panencephalitis (SSPE) patients has been studied by isoelectric focusing (IF) followed by direct immunofixation. The oligoclonal bands demonstrated by IF were both homogeneous and heterogeneous with regard to the light chain type; in the MS patients there was a prevalence of heterogeneous bands and of homogeneous bands of lambda type, while in SSPE a slight prevalence of kappa homogeneous bands was found. The kappa homogeneous bands were preferentially disposed in a more cathodal position in respect to lambda IgG bands; in some cases bands probably constituted only of free light chains of lambda type were found. Finally, in some cases, the oligoclonal IgG pattern was more distinct after immunofixation than after basal IF.

Adult↗
PubMed1981

Monophosphate, the only phosphoric ester of thiamin in the cerebro-spinal fluid.

With a specific and sensitive electrophoretic-fluorometric method, thiamin was found in the cerebro-spinal fluid of different mammals both in free and phosphorylated form, monophosphate being the only thiamin phosphoric ester. In humans, its amount was about 60% of total thiamin. Alcoholism greatly lowered total thiamin content, affecting both thiamin forms.

Alcoholism↗
PubMed1981

Cerebrospinal fluid IgG changes in subacute sclerosing panencephalitis in the various stages of the disease and during isoprinosine therapy.

The cerebrospinal fluid (CSF) levels of IgG and the separation of the CSF and serum proteins by isoelectric focusing (IEF) were studied in 5 patients with subacute sclerosing panencephalitis (SSPE). Oligoclonal IgG fractions were found in the CSF of all the patients. The CSF IgG, IgG-Index and IgG SYN values were higher in the patients observed in the earlier than in those seen in the later stages of the disease. 1 of the 3 patients treated with isoprinosine presented a partial clinical remission accompanied by an increase in the parameters of intrathecal IgG synthesis.

Adolescent↗
PubMed1980

The cerebrospinal fluid tau-transferrin. Isoelectric focusing study on 674 neurological patients.

The frequency of the two tau-fractions in isoelectric focusing examination of cerebrospinal fluid proteins has been studied in 674 neurological patients. The double tau-fraction was found in 151 patients (22.4%); this finding was not characteristically associated with any particular disease, but its frequency was high in hereditary diseases (13 cases out of 30; 43.3%), mainly Charcot-Marie-Tooth's disease.

Charcot-Marie-Tooth Disease↗
PubMed1980

[Comparative quantitative and qualitative analysis of intrathecal IgG synthesis during multiple sclerosis and other neurologic diseases].

Intrathecal IgG synthesis has been studied in neurological patients by both quantitative and qualitative methods. An elevated correlation was found between IgG/Albumin quotient, IgG-Index and IgG SYN: moreover the appearance of oligoclonal IgG bands in CSF seems clearly related to high IgG Index values, as observed by statistical analysis. Nevertheless oligoclonal pattern in CSF is always present in diseases associated with immunological abnormalities, while quantitative parameters may be found elevated also in the diseases without a clear immunological disturbance. The authors stress the great importance of CSF examination by Isoelectric Focusing in the evaluation of intrathecal IgG synthesis in multiple sclerosis.

Humans↗
PubMed1979

Intrathecal IgG synthesis in multiple sclerosis and other neurological diseases: a comparative evaluation by IgG-index and isoelectric focusing.

Intrathecal IgG synthesis has been investigated by determining the IgG index and by isoelectric focusing in 30 cases of definite multiple sclerosis, in 15 cases of probable multiple sclerosis and in 128 patients affected by other neurological diseases. The blood-brain barrier function was evaluated at the same time by serum albumin/CSF albumin quotient and isoelectric focusing. The IgG index was found elevated in 73.3% of definite multiple sclerosis patients, while oligoclonal IgG bands occurred in 90%. In the other neurological diseases the IgG index was abnormally increased in 35.1% but IgG bands were present only in cerebrospinal fluid (CSF) in 1.5% and both in the CSF and serum in 7% of patients. The high capacity of isoelectric focusing to detect IgG oligoclonal bands in the CSF is pointed out as an extremely useful diagnostic tool in multiple sclerosis.

Adult↗
PubMed1978

[B-lymphocytes in multiple sclerosis: studies concerning their levels in the blood and cerebrospinal fluid].

In this paper the B lymphocyte population was investigated by fluoresceinated immunoglobulin assay in peripheral blood and cerebrospinal fluid (CSF) in M.S. patients and other neurological diseases taken as control. In peripheral blood there was no significant difference in two groups considered. In CSF there was a higher percentage of B-cells only in M.S. patients. This datum was more evident when the percentage of B cells was simultaneously determined in CSF and blood. It can be hypothesized the existence of subpopulations of B cells synthesizing Ig in the CST.

Adult↗
PubMed1977

Hemifacial spasm associated with dolichomegavertebrobasilar anomaly.

3 patients suffering from long-lasting "cryptogenetic" hemifacial spasm in association with dolichomegavertebrobasilar anomaly, are described. The angiographic examinations confirm the anomaly and put in evidence the patholphysiologic value of segment V4 of the vertebral artery at the same side of the spasm. Classical electromyographic examinations, and methods used to study the blink reflex, seem to rule out the hypothesis of a brain stem involvement as the only and sufficient pathologic mechanism. The peripheral pathogenesis is the most likely one.

Aged↗
PubMed1977

Comparative Doppler directional sonographic and ophthalmodynamographic study in the occlusion of the internal carotid artery.

In the occlusion of the internal carotid artery, the change occurring in the internal-external carotid pressure gradient may cause flow reversal within the ophthalmic artery and its branches. Ophthalmodynamographic, Doppler directional sonographic and angiographic investigations were performed in 21 cases (11 total occlusions, 6 severe and 4 moderate stenoses of the internal carotid artery). The authors compare the results of these investigations and discuss the practical importance of Doppler directional sonography and the significance of flow reversal in the ophthalmic artery.

Adult↗