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Biomedical subjects

M Porter

Publications and source records attributed to M Porter.

At least 19 recordsLinked to original sources
PubMed1992

Development of the brachial spinal cord in the marsupial Macropus eugenii (tammar wallaby).

The development of the brachial spinal cord was studied in the marsupial Macropus eugenii (tammar wallaby) on postnatal days 1-34. On day 1 the spinal cord was histologically immature, with a deep central canal, proliferating neuroepithelium and roof and floor plates. The lateral motor column had formed, and forelimb muscles contained primary myotubes. The spinal cord gradually attained a mature appearance between days 1-34. The results confirm the suitability of the wallaby spinal cord for studies of early mammalian development.

Aging↗
PubMed1992

Plasma, platelet and erythrocyte glutathione peroxidases as risk factors in ischaemic heart disease in man.

1. Plasma, platelet and erythrocyte glutathione peroxidase activities and serum lipid concentrations were measured in patients with ischaemic heart disease and matched control subjects. 2. Mean plasma and platelet glutathione peroxidase activities were significantly lower in the patients with ischaemic heart disease. Erythrocyte glutathione peroxidase activities and serum lipid concentrations were similar in patients with ischaemic heart disease and control subjects. 3. No correlations between plasma, platelet and erythrocyte glutathione peroxidase activities were observed. 4. The combination of plasma and platelet glutathione peroxidase activities provided an 86% discrimination between patients with ischaemic heart disease and matched control subjects. 5. Our data suggest that plasma and platelet glutathione peroxidases may be significant risk factors for ischaemic heart disease. Plasma glutathione peroxidase is a previously unrecognized risk factor.

Adult↗
PubMed1992

Fiscal and clinical evaluation of patient care. A case management model for the future.

The cost of healthcare within the United States continues to climb as does the number of individuals who have limited access to the healthcare system. By the year 2000, healthcare costs are predicted to comprise 15% of the gross national product. Over the last 10 years, the number of Americans who do not have financial protection from medical costs has risen dramatically. Presently, an estimated 35 million individuals have no insurance or other coverage.

Adult↗
PubMed1992

Immunoblotting of transferrin in the identification of cerebrospinal fluid otorrhoea and rhinorrhoea.

Cerebrospinal rhinorrhoea is potentially serious due to the risk from infection. In patients presenting with a nasal discharge of clear fluid it is important to identify the nature of the fluid. Cerebrospinal fluid is readily identified by the presence of asialo-transferrin (tau protein). A method is presented for the identification of tau protein based upon agarose electrophoresis, followed by transfer onto cellulose nitrate membrane and immunochemical detection of transferrin. The method is reliable, sensitive and simple, and requires only basic electrophoresis apparatus.

Asialoglycoproteins↗
PubMed1991

The effect of ice packs upon nasal mucosal blood flow.

The effect on nasal mucosal blood flow of ice packs on the forehead and ice packs within the mouth was investigated in 16 healthy subjects. The laser Doppler flowmeter was used to record changes in blood flow to the inferior turbinate, as measured by change in the flux. Ice packs within the mouth produced a significant decrease in nasal mucosal blood flow (p less than 0.05). The average fall was 23% (SEM 5.9) compared with the control measurements. No significant change was recorded following the application of ice packs to the forehead. The results of this study question the scientific rationale behind the use of forehead ice packs in clinical practice.

Adult↗
PubMed1988

The Sheehan total knee arthroplasty. A retrospective review.

Sixty Sheehan total knee arthroplasties (TKA) in 44 patients were reviewed 3.5 years following surgery. Patient mobility was improved, but only 29 knees were completely free of pain. In 18 knees there was a complaint of pain localized to the patellofemoral joint, and in five knees the pain was severe enough to require further surgery. Complications included three knees with presumed deep infection and three knees with tibial stud fractures. Aseptic loosening did not occur, although sinkage of the tibial component was observed. Revision arthroplasty was not successful mainly because of poor residual bone stock. Salvage surgery included three successful arthrodeses. The high incidence of patellofemoral problems and violation of bone stock make the current surface replacements attractive alternatives for TKA.

Adult↗
PubMed1987

Fractures of the distal radius. Intermediate and end results in relation to radiologic parameters.

The purpose of this study was to quantify the functional impairment following distal radial fractures and to identify the factors affecting prognosis. One hundred fifteen patients were assessed six months and two years following initial injury. On final assessment, subjectively, 56% had good, 39% had fair, and 5% had poor results. Median grip strength improved from 51% to 78%, range of movement from 87% to 94%, and wrist torque from 93% to 100%. Redisplacement occurred in 59%; only 33% clinically and 19% radiologically had perfect cosmetic results. Radial malunion was important functionally. Only when the dorsal angle exceeded 20 degrees or the radial angle fell below 10 degrees with a 30 degrees mean was there reduction in grip strength (p = 0.05). Comminution and intraarticular involvement predisposed to a median loss of movement of 15% and 11%, respectively (p = less than 0.05). Patients requiring physiotherapy formed a poor prognostic group. A combination of factors is responsible for poor results. Attention should be directed toward early and adequate rehabilitation of the injured hand and wrist.

Adolescent↗
PubMed1985

Clobetasol propionate versus fluocinonide creams in psoriasis and eczema.

A double-blind, parallel comparison was made of the short-term efficacy and safety of three times daily regimens of 0.05% clobetasol propionate cream and 0.05% fluocinonide cream in 114 adolescent and adult patients with psoriasis and 113 with eczema. After 2 weeks of topical applications, patients were assessed according to (1) investigators' overall judgment of clinical response, (2) degree of severity of specific signs and symptoms, and (3) patients' evaluation of improvement. In all three response categories in psoriasis, and in two of three in eczema, clobetasol was statistically significantly superior to fluocinonide (p less than 0.05-p less than 0.001). Healing commenced more rapidly with clobetasol and there was no indication of tachyphylaxis. In contrast, the healing rate with fluocinonide slowed noticeably after the first week, and there was a greater tendency to relapse following fluocinonide treatment. Both regimens were safe: drug-related side effects were generally mild and occurred most commonly with fluocinonide therapy in eczema patients. Overall, drug-related effects occurred in 4% of patients receiving clobetasol and 12% receiving fluocinonide (p less than 0.05). Transient morning plasma cortisol reductions below 5 micrograms/dl occurred in 6% of clobetasol-treated patients, reverting to normal within 1 week of the end of treatment.

Administration, Topical↗