PubMed Health⌕ Search

Biomedical subjects

M Probst

Publications and source records attributed to M Probst.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Early therapy with immunoglobulins after extensive abdominal operations. A random study (author's transl)].

A random study with 100 patients was conducted to show whether the immunoglogulin Gamma Venin, when given after rectum extirpation, has an effect on wound healing and other infections. The patients in the test group received 10 g of Gamma Venin within the first 48 h after surgery. The number of days with purulent wound secretion were reduced to 0.71 (test group) as opposed to 7.61 (control) with statistical significance. Primary wound healing was 37% in the test group and 9% in the control group (P < 0.01). Other infections occurred in a similar range. The time of hospitalization was 3.44 days less than in the test group (P < 0.01).

Abdomen↗
PubMed1980

[One-stage-resection of colon and rectum without protective colostomy -- a safe procedure (author's transl)].

A total of 1117 one-stage-resections was evaluated. The rate of anastomotic insufficiency came up to 3.6% (cancer) and 5.7% (diverticulitis). Mortality rate in cancer patients due to local complications came up to 1.1%, due to general causes to 4.9%, the percentage of diverticulitis of the sigmoid colon was 1,9% and 0,9% respectively. Impaired wound healing in cancer patients was observed in 9,2% and in patients with diverticulitis in 13.3%.

Colon↗
PubMed1979

[Does a one-time colonic or rectal resection without protective colostomy increase the rate of postoperative complications?].

The rate of postoperative complications is the decisive criterion in evaluating the preoperative preparation of the large intestine, the operative methods, and the technique of anastomosis. Preparations for colorectal surgery include administration of antibiotics and the use of a three-row suture method of anastomosis without the protection of an intestinal fistula. The results of 1054 colorectal resections are promising: The rate of anastomotic insufficiency was 3.9% after resection of tumors and 4.9% after resection of inflamed diverticula. Lethality from local causes was 1.2% and 1.9%, respectively. Disturbance of wound healing occurred in 10.7% of the cases.

Colon↗
PubMed1978

[Preoperative preparation in colorectal surgery: antibiotics (author's transl)].

Out of a total of 2727 operations of the large bowel because of tumors and inflammatory disease, performed over a 14-year period, 897 were one-stage resections of the colon and rectum without relaxing colostomy. Standard preoperative preparation of the bowel consists of a balanced diet, laxatives, and enema supplemented by 9 g Neomycin and 1.8 g Achromycin, within a 2-day period. Disturbances in wound healing occurred in 12.5%, seroma included. Anastomotic insufficiency occurred in 4%, and fatal fecal peritonitis due to tumors in 1.3% and due to diverticulitis in 1.2%. Total mortality was about 5.7%. Postoperative hospitalization after resections because of tumors was 15 days and because of diverticulitis, 19 days.

Cathartics↗
PubMed1977

Distribution of IgG subclasses in commercial and some experimental gamma-globulin preparations.

The IgG subclass distribution was determined in six commercial and in four experimental human gamma-globulin preparations. The concentrations of IgG subclasses were measured in a modified radiommunoassay using subclass-specific antisera. In commercial gamma-globulins, the distribution of the subclasses corresponded roughly to the distribution in normal human serum. A considerable enrichment of the IgG 4 was found in experimental lots prepared either from the ethanol fraction III or from the rivanol-precipitable IgG.

Blood Specimen Collection↗
PubMed1977

Massive pancreatic ascites without carcinoma. Report of three cases.

Three cases of benign pancreatic ascites have been added to 94 cases reviewed from the literature. Common characteristic of this syndrome were chronic alcoholism, intermittent abdominal pain, nausea, vomiting and considerable weight loss which occurred despite fluid accumulation. Markedly elevated protein and amylase levels in the ascitic fluid, hyperamylasemia and hypoalbuminemia were the major diagnostic clues as to the pancreatic origin of ascites. Predominant pathological findings were chronic pancreatitis with or without pseudocysts, pancreatic duct disruption, lesion which were considered to be the major pathogenic factor besides lymphatic obstruction by leaking pancreatic juice into the peritoneal cavity. Early laparotomy for diagnosis and treatment is essential. ERP might be of great value in diagnosis.

Adult↗
PubMed1977

[Differential diagnosis of tumors of the duodenal bulb by endoscopy and biopsy (author's transl)].

Duodenoscopy was performed in 2 602 patients; malignant tumors were found in 5, hyperplasia of Brunner's glands in 5, hyperplasia of lymphatic follicles in 26, inflammatory pseudo-polyps in 9, and ectopic gastric mucosa in 5 cases. Only 3 of the big tumors had been detected by x-ray examinations; enlarged lymphatic follicles and the polyps had escaped x-ray detection altogether. Infiltration of the mucosa by tumor tissue can be suspected merely on the ground of endoscopic inspection with a high degree of probability. Histological diagnosis depends on forceps biopsy. Big particle biopsy of submucosal tumors with a sling carries a high risk, which however has to be taken in order to obtain a definite diagnosis. Tumors of the duodenal bulb caused by inflammatory processes do present considerable diagnostic problems. Special problems of diagnosis and therapy of the cases presenting with hyperplasia or adenoma of Brunner's glands are discussed in a special section.

Adenocarcinoma↗
PubMed1976

[Changes of kappa/lambda ratio of human serum immunoglobulins in the course of development].

In sera of normal individuals of different age groups the kappa- and lambda-type immunoglobulins were measured and the kappa/lambda ratio was calculated. The relative concentration of lambda-immunoglobulins in sera of newborns and young children was found to be significantly higher than in the adult sera. The well-known asynchronous maturation of immunoglobulin classes and IgG subclasses in the early childhood is evidently accompagnied by a asynchronous maturation of immunoglobulin types.

Adult↗
PubMed1976

[Endoscopic diagnosis of carcinoma in the operated stomach].

In 24 000 gastroscopies at 4 medical departments 705 subjects with gastric operations done more than 5 years before had been studied. 39 of 608 patients with Billroth II, 5 of 81 with Billroth I and 4 out of 15 with gastroenterostomy were found to be suffering from carcinoma of the gastric stump. The primary gastric operations were performed at a medium age of 40 years. The interval between surgery and development of carcinoma averaged 24 years and was shorter in patients operated at a higher age. Besides age and interval since operation risk factors were apparently former gastric ulcers or polyps. Indications for endoscopic follow-up studies of gastrectomized patients to improve surgical results with carcinoma of the gastric stump have been suggested.

Adenocarcinoma↗