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Biomedical subjects

M Puletti

Publications and source records attributed to M Puletti.

At least 19 recordsLinked to original sources
PubMed1991

[The measurement of CoQ10 in the acute phase of a myocardial infarct].

The authors have studied the behaviour of ubidecorenone (Co Q10) in the acute phase of myocardial infarction in 24 patients, 19 male and 5 female, mean age 56.8 +/- 3.3. Ubidecorenone level was determined on admittance, after 48 hours and on the 7th and 30th days. A significant decrease was observed from the first to the 3rd day (mean values 0.90 +/- 0.18 microgram/ml vs 0.72 +/- 0.22, p less than 0.01). Thereafter a progressive rise was observed, but at the 30th day mean values were still below the basal ones. No significant differences were observed between patients treated with fibrinolytic agents and those not so treated, nor between those in whom reperfusion was obtained and the others. Nor was there a proven correlation with changes in creatinkinase. The behaviour of ubidecorenone may be associated with increased consumption for metabolic needs and increased destruction in scavenger action, and also to a lesser extent to decreased production due to lower food intake.

Aged↗
PubMed1990

Complete atrioventricular block with QRS complexes of variable amplitude.

Nonrespiratory QRS amplitude variations related to PR interval length were observed in a case of complete atrioventricular (AV) block with narrow QRS complexes. This electrocardiographic pattern was studied, taking into consideration the greater deflection of the ventricular complexes (R- or S-wave) on each standard lead and by analyzing three groups of QRS (A, B, C) divided in relation to the different timing of the atrial systole. A significant variation appears in the entity of the mitral flow, as assessed by Doppler echocardiography evaluation, related to PR interval length, and a significant inverse correlation was found between QRS variability and ventricular diastolic filling.

Adolescent↗
PubMed1989

Hypothyroidism and thyroid autoimmunity in acute myocardial infarction (AMI).

It has been suggested that subjects with thyroid autoimmunity are more frequently affected by acute myocardial infarction (AMI), than the general population (Lancet ii, 155-158, 1977). Serum thyroid antibodies (microsomal and thyroglobulin) were measured in a cohort of 132 males admitted consecutively to the Coronary Unit of Clinica Medica II Univ. "La Sapienza" of Rome with AMI. In the AMI group the thyroid autoimmunity was twice as frequent as in an age matched random population (9.1 vs 17.4%), but the association was statistically weak (p less than 0.05). In the group over 60 y two cases of overt hypothyroidism were found and none in the control group. The prevalence of 2.5% is higher than that reported in previous surveys carried out in elderly populations. No differences have been demonstrated in concentration of serum cholesterol, triglycerides, apolipoprotein A and B between patients with and without thyroid autoimmunity, although the serum cholesterol of AMI patients and those with asymptomatic thyroiditis was significantly higher than that of the general population. It is concluded that the prevalence of thyroid autoimmunity and hypothyroidism are increased in AMI and migth thus contribute to development of hypercholesterolemia and/or immune mechanisms.

Adult↗
PubMed1989

[Incidence and prognostic significance of anterior precordial ST segment depression in acute inferior myocardial infarct].

In order to evaluate the incidence and prognostic significance of anterior precordial ST segment depression (decreases ST) in acute inferior myocardial infarction (MI), 158 patients with inferior MI were selected. In 90 patients (56.9%) an anterior decreases ST was associated with inferior lesion wave (group A), and in 68 patients (43.1%) only an ecg pattern of inferior myocardial infarction (group B) was present. No significant statistical differences were observed in mortality (group A 10% vs group B 10.2%), in compliances (group A 54.4% vs group B 47.0%) and in higher peak serum ck-levels (group A 83.3% vs group B 69.1%) in two groups during hospitalization period. In conclusion the anterior decreases ST during inferior MI should not be considered a negative prognostic sign. These favourable results are probably related to stringent criteria for ecg diagnosis of inferior myocardial infarction used and to exclusion of all patients with non contemporary evolution of anterior decreases ST and inferior lesion wave.

Adult↗
PubMed1979

Atrial repolarization: its role in ST elevation.

In four patients, ectopic supraventricular rhythm (or beats) with cephalad anomalous atrial activation and, generally, a short PR, were always associated with an ST elevation in the leads with a negative P wave. An inverted Ta wave appears to be responsible for the ST elevation.

Adult↗
PubMed1979

[The causes of death after acute myocardial infarction (author's transl)].

Following a brief outline on problems concerning methodology, the cause of death is analysed in 110 patients dying from acute myocardial infarction during hospitalization. Autopsy studied were carried out in 78 cases. Of the various causes, the most frequent were forms of contractile insufficiency (EPA, shock, shock + EPA, biventricular congestive heart failure) which were responsible for 50.90% of cases; followed by cardiac rupture (considered in a single group with electromechanic dissociations of the patients not submitted to autopsy studies since in the experience of the Authors cardiac rupture almost always presents with this pattern) with a frequency of 29%. The frequency of arrhythmias, on the other hand, is very low, particularly in the coronary care unit where it is practically a negligible causa mortis 2.72%): even if sudden death, in patients who were not monitored, is included amongst the arrhythmias, the percentage is still only about 10%. Embolism (usually pulmonary, but systemic in one case) was the cause of death in 5 patients (4.54%). Three patients over 80 years of age died from ischemic cerebral episodes. Age, sex, and site of infarction, do not appear, in the present series, to have a determinant effect in the cause of death; a higher frequency of rupture in the female sex was not, for example, confirmed. On the basis of the observations in the present series, any relationship between cardiac rupture and anticoagulating therapy, steroid treatment, application of endocavitary stimulators, or early ambulation is excluded. It is also excluded that reanimation, as hypothesized by some Authors, may be responsible for rupture.

Acute Disease↗
PubMed1978

Infarct as a stress agent: life history and personality characteristics in improved versus not-improved patients after severe heart attack.

Fifty-eight male subjects admitted to an intensive coronary care unit were interviewed and underwent psychometric testing on the second--third day after a severe heart attack (infarct). Seven-ten days following admission, the clinical condition of the patients was evaluated by the attending cardiological staff and rated on a three point scale. The patients were divided, on the basis of the clinical rating, into two groups: improved (N = 25) and non-improved (N = 33). Life history characteristics, MMPI personality profiles, and State-Trait anxiety scores were then compared for the two groups. The not-improved group showed the higher scores on almost all the MMPI scales, higher anxiety scores and more work-related problems than the improved group. Such data give some empirical support to the hypothesis that the physiological and hemodynamical conditon of the cardiac patient is in some way correlated with the patient's style of coping with stress, and his history of previous life stress situations.

Adaptation, Psychological↗