PubMed Health⌕ Search

Biomedical subjects

M Pulik

Publications and source records attributed to M Pulik.

At least 55 records · Page 3Linked to original sources
PubMed1994

[Agranulocytosis induced by synthetic antithyroid drugs: efficacy of hematopoietic growth factors].

Agranulocytosis is the most serious problem, potentially fatal, that can occur during antithyroid drug therapy. The use of hematopoietic growth factors is an attractive approach to reduce the period of this drug-induced neutropenia. We report two cases of severe antithyroid drug-related agranulocytosis (granulocyte count < 0.1 x 10(9)/L) treated with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). The delay to observe a granulocyte count superior to 1 x 10(9)/L was respectively 1 and 5 days. Our results, with others, clearly show that hematopoietic growth factors are effective in severe antithyroid drug-induced agranulocytosis.

Adult↗
PubMed1992

[Acquired protein S deficiency in HIV infections].

A prospective study of protein S was carried out in 17 consecutive HIV-infected patients. One subject was excluded because of severe chronic liver disease. Of the 16 evaluable patients (10 men, 6 women), 3 had AIDS, 7 ARC, 4 lymphadenopathy and 2 were asymptomatic. Total protein S and C4bBP (bound protein) were normal in all of them. In contrast, all but one subject had a free protein S deficiency: 35.5% (range: 0-68) for the whole group; 12.4% (range: 0-29) for the women: 50.9% (range: 27-68) for the men. From these results, we concluded that: a) free protein S deficiency is common in HIV-infected patients, b) this deficiency is more pronounced in female than male subjects, and c) this deficit is not linked to elevated C4bBP levels. The mechanism and the clinical consequences of this deficiency are discussed.

Adult↗
PubMed1990

[Oral erosive lichen planus: think of chronic liver disease].

We report a case of lichen planus associated with an active chronic hepatitis. The relationship between lichen planus and chronic hepatic disorders (chronic hepatitis, primary biliary cirrhosis) is discussed. Physiopathologic similarities with chronic graft-versus-host disease are emphasized.

Chronic Disease↗
PubMed1989

Tumoral nasopharyngeal lymphoid hyperplasia in human immunodeficiency virus-infected patients.

Two patients presented with a large tumoral nasopharyngeal lesion with obstructive symptoms, which suggested a malignant tumor. They were black men of Caribbean origin who were infected with human immunodeficiency virus 1. In both cases, histologic examination revealed intense but benign lymphoid follicular hyperplasia, and immunohistochemical studies were consistent with its polyclonal nature. DNA studies performed on tumoral tissue failed to disclose immunoglobulin or T-cell receptor gene rearrangements. In one biopsy specimen, DNA hybridization using Epstein-Barr virus-specific probes showed no evidence of Epstein-Barr virus-DNA sequences. The nasopharynx can be involved in the diffuse extranodal lymphoid hyperplasia associated with human immunodeficiency virus infection.

Acquired Immunodeficiency Syndrome↗
PubMed1988

[Tumors of the nasal cavity in human immunodeficiency virus infection. A case of polyclonal lymphoid hyperplasia].

HIV virus infection is frequently accompanied by polyclonal or monoclonal lymphoid proliferations. The authors report the first case of a tumour of the cavum in a Haitian subject with HIV infection. This large tumour was associated with parotid swelling and a buccal and ocular sicca syndrome. Histological examination revealed Sjögren type of lympho-epithelial infiltration in the parotid and salivary glands. Biopsy of the cavum demonstrated lymphoid hyperplasia without a monoclonal component. There was no lymphoid proliferation outside of the ear, nose and throat region. The various benign and malignant lymphoid proliferations observed during HIV infection are recalled. Their pathophysiology is discussed: role of EBV in B cell lymphoid proliferations, specific cytotoxicity against cells infected by HIV in T8 proliferations.

Acquired Immunodeficiency Syndrome↗