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Biomedical subjects

M Pura

Publications and source records attributed to M Pura.

5 recordsLinked to original sources
PubMed2006

[Primary aldosteronism in gravidity].

Endocrinology and obstetrics have one thing in common--diagnosis and treatment endocrine diseases in gravidity. These are modified by physiological changes in gravidity, often missing data and tests in normal condition and the influence of diagnosis and treatment on the pregnant female and fetus have also to be taken into consideration. If diagnosis of primary aldosteronism is suspected, suprimed plasmatic renin activity is determinant indicator (disregarding arterial hypertension, hypokaliaemia, hyperkaliuresis and proteinuria) as well as ultrasound diagnostics or adrenal gland diagnostics means magnetic resonance imaging. Aldosteron produced adenomas may by treated by adrenalectomy in the second trimester, late diagnosed adenoma and hyperplastic forms are treated by the administration of the respective medicaments.

Female↗
PubMed2005

[Differential diagnosis of peripheral neuropathy].

Neuropathies can be caused by metabolic-endocrine, toxic, and hereditary disorders, various conditions of nutrition deficiency, inflammatory or systemic diseases, vasculopathies, and they can be part of the paraneoplastic symptomatology as well. Diabetes mellitus (DM) is the most common cause of neuropathy in our population. Diabetic polyneuropathy represents the most frequent form of polyneuropathy in well-developed countries, indicates more admissions that other diabetic complications and has important impact on the quality of patients' life. From the differential diagnostic point of view, it is important that signs of the diabetic neuropathy are non-specific and identical for all neuropathies. Each neuropathy represents complex of sensory, motor and vegetative signs. In addition to the clinical features, biochemical and paraclinical investigations are conclusive for identifying the etiology of neuropathy. Suspicion for non-diabetic etiology of neuropathy is increased in neuropathy developed earlier to DM, neuropathy in very good controlled DM, and asymmetric neuropathy. After elucidation of an atypical neuropathy signs, neurological and electromyographical studies should follow. With the development of serological and genetic tests, autoimmune and hereditary neuropathies are increasingly diagnosed in cases of to that time unclassified idiopathic neuropathies. Even after complex investigation procedures, the etiology of polyneuropathy remains unrevealed in approximately 50% of cases.

Diagnosis, Differential↗
PubMed2005

[From the history of endocrinology: reminiscence of the discovery of adrenocortical hormones].

In the article authors describe the milestones in history of discoveries of the adrenocortical hormones. Preparation of the adrenal extract cortine was the first experimental contribution. Cortine prolonged life of animals whose adrenals have been removed and had beneficial effects in patients with Addison disease (AD). It was mixture of compounds comprising carbon, hydrogen and oxygen that belong to the steroids. From those deoxycorticosterone had impact on mineral metabolism, substances that Kendall termed as compounds A, B, E, and F influenced metabolism of saccharides and proteins. In 1929 Dr. Hench had observed that the painful symptoms of rheumatoid arthritis (RA) were relieved in a patient who developed jaundice and in 1931 he remarked favourable effects of pregnancy to the course of RA. He suggested that some agent (substance X) was present during jaundice and in pregnancy through that the symptoms of RA were relieved. In 1941 interest concerned to the compound A, however, this was almost ineffective in patients with AD. In 1948 compound E was successfully administered to patients with AD and RA for the first time. Concerning the relation between vitamin E Kendall and Hench gave compound E distinctive name cortisone. Consequently it was confirmed that compound F (hydrocortisone) is the final product of the adrenal cortex. Appreciating the work of the most significant groups was awarding the Nobel Prize to Edward Kendall, Tadeusz Reichstein and Philip Hench in 1950.

Adrenal Cortex Hormones↗