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M Puranen

Publications and source records attributed to M Puranen.

41 records · Page 3Linked to original sources
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Diabetes mellitus and brain atrophy: a computed tomography study in an elderly population.

Previous studies have suggested that noninsulin dependent diabetes mellitus (NIDDM) could lead to learning and memory deficits. We studied cognitive performance and computed tomography (CT) findings of the brain in elderly subjects with drug treated NIDDM (n = 12), with diet treated NIDDM (n = 13), and in nondiabetic individuals (ND, n = 59). The cognitive performance (orientation and up-to-date knowledge, praxic functions, understanding of speech, expressive speech, memory, general reasoning) did not differ between the groups. The drug treated diabetics had more pronounced central temporal atrophy compared to that in the ND subjects as evidenced by wider right temporal horn (ANCOVA adjusted for age, p = 0.011). The drug treated diabetics (all women) also had wider frontal horns than did the ND women. The CT measures of diet treated diabetics were comparable with those of the ND group. The fasting glucose level was positively correlated with the width of the right temporal horn but not with other CT measures in diabetic subjects. The results suggest that NIDDM and poor glucose control may carry a risk for accelerated brain atrophy in the elderly.

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Long-term effects of bilateral frontal lobe lesions from neuropsychiatric and neuroradiological aspects.

Long-term effects of bilateral prefrontal lesions were studied in 14 lobotomized schizophrenic patients who were operated in the fifties. CT scans revealed cystic bilateral frontal lesions in almost every patient and cortical atrophy was seen in 5 patients. The prefrontal syndrome was severe in 1 patient, marked in 1 patient, mild in 9 patients and absent in 3 patients. Primitive reflexes could be elicited in 2 patients, 3 patients suffered from epileptic seizures, and 8 from minor motor defects. Four patients committed a homicide in the period after the operation, which indicates that the frequency of committing homicidal acts had doubled when compared with the situation before the operation. The incidence of homicides after lobotomy is extremely high considering that all patients except 1 were kept under continuous observation in hospitals.

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Polymerase chain reaction amplification of human papillomavirus DNA from archival, Papanicolaou-stained cervical smears.

OBJECTIVE: To test the applicability of four protocols in recovering DNA suitable for amplification with the polymerase chain reaction (PCR) in archival, Papanicolaou-stained cervical smears. STUDY DESIGN: The most efficient method was used to isolate DNA from 11 archival, Papanicolaou-stained smears with cytopathic changes due to human papillomavirus (HPV) infection to confirm the presence of HPV DNA. RESULTS: beta-Globin was successfully amplified in all smears, while HPV DNA was detected in 6 of 11. Four of the four HPV DNA-negative smears were classified as high grade squamous intraepithelial lesions. Failure to detect HPV DNA might have been due to the low copy number of HPV DNA or deletion of the L1 region. CONCLUSION: High cellularity and the method of recovering DNA from the smear are important determinants of successful amplification of HPV DNA in archival cervical smears.

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