Biomedical subjects

M Q Wang

Publications and source records attributed to M Q Wang.

At least 19 recordsLinked to original sources

PubMed2003

Effects of L-carnitine on growth performance, carcass composition, and metabolism of lipids in male broilers.

We studied the effects of L-carnitine on growth performance, carcass composition, and lipid metabolism in male broilers. Six hundred male commercial broilers were allotted to five groups, each of which included three replicates (40 birds per replicate). The groups received the same basal diet supplemented with 0, 25, 50, 75, or 100 mg/kg L-carnitine, respectively. The feeding trial showed that L-carnitine had no significant effect on daily gain or feed conversion. Supplementation with L-carnitine (above 25 mg/kg) in the diet increased breast muscle yield (P < 0.05) and crude fat content of the muscles and decreased abdominal fat content (P < 0.05). Addition of 50, 75, or 100 mg/kg L-carnitine to the diet decreased total activities of glucose-6-phosphate dehydrogenase, malic dehydrogenase, isocitrate dehydrogenase, and lipoprotein lipase (P < 0.05) in the subcutaneous fat and total activity of carnitine palmitoyltransferase-I (P < 0.05) in breast muscles. The results of this study indicate that L-carnitine could reduce the deposit of subcutaneous fat by decreasing total activities of enzymes in the fat and enhance intramuscular fat by decreasing the activity of carnitine palmitoyltransferase-I in breast muscles.

Adipose Tissue↗

PubMed2003

Effects of dietary fructooligosaccharide on digestive enzyme activities, intestinal microflora and morphology of male broilers.

Two hundred forty male Avian Farms broiler chicks, 1 d of age, were randomly allocated to four treatments, each of which had five pens of 12 chicks per pen. The chicks were used to investigate the effects of fructooligosaccharide (FOS) on digestive enzyme activities and intestinal microflora and morphology. The chicks received the same basal diet based on corn-soybean meal, and FOS was added to the basal diet at 0, 2.0, 4.0, and 8.0 g/kg diet at the expense of corn. Addition of 4.0 g/kg FOS to the basal diet significantly increased average daily gain of broilers. The feed-to-gain ratios were significantly decreased for the birds fed diets with 2.0 and 4.0 g/kg FOS versus the control. Addition of 4.0 g/kg FOS enhanced the growth of Bifidobacterium and Lactobacillus, but inhibited Escherichia coli in the small intestinal and cecal digesta. Supplementation of 2.0 or 4.0 g/kg FOS to chicks significantly improved the activities of amylase compared to the control (12.80 or 14.75 vs. 8.42 Somogyi units). A significant increase in the activities of total protease was observed in 4.0 g/kg FOS-treated birds versus controls (83.91 vs. 65.97 units). Morphology data for the duodenum, jejunum, and ileum showed no significant differences for villus height, crypt depth, or microvillus height at the duodenum. By contrast, addition of 4.0 g/kg FOS significantly increased ileal villus height, jejunal and ileal microvillus height, and villus-height-to-crypt-depth ratios at the jejunum and ileum and decreased crypt depth at the jejunum and ileum. However, addition of 8.0 g/kg FOS had no significant effect on growth performance, digestive enzyme activities, intestinal microflora, or morphology.

Animal Feed↗

PubMed2001

Isolated lower extremity chemotherapeutic infusion for treatment of osteosarcoma: experimental study and preliminary clinical report.

PURPOSE: To increase the dose of drug delivered to a tumor while maintaining tolerable systemic side effects, an interventional technique of isolated lower extremity infusion was investigated. MATERIALS AND METHODS: Experiments were performed in eight dogs. Four dogs were treated by a combination of intraarterial (IA) femoral cisplatin infusion at a dose of 2.0 mg/kg with drug removal from the ipsilateral extremity venous blood by a dialyzer. The other four dogs comprised the control group. In these animals, left femoral arterial IA cisplatin infusion was performed without dialysis. Leukocyte and platelet counts, blood urea nitrogen (BUN) levels, and serum creatinine levels were recorded before and after the treatment. Subsequently, two human patients with inoperable osteosarcoma were treated with the isolated infusion. RESULTS: In the experiments, 85%-90% of the free platinum that entered the dialyzer was removed. The peak systemic plasma cisplatin concentrations in animals undergoing dialysis were reduced by 81.25% compared to those in animals undergoing femoral IA infusion without hemodialysis. There were no significant changes in the hematologic profiles or BUN and serum creatinine levels in the experimental animals. However, in the control group, all dogs developed myelosuppression and severe renal toxicity after IA infusion of the same dose of cisplatin. Clinically, immediate relief of symptoms related to the primary tumor was achieved in both human patients after the combination of isolated IA infusion and embolotherapy. CONCLUSION: Single-pass hemodialysis removed a significant amount of cisplatin after regional IA infusion, reduced systemic toxicity, and permitted survival of the experimental animals. In two patients with osteosarcoma, percutaneous isolated lower extremity chemotherapeutic infusion therapy and embolotherapy were performed safely with partial responses.

Adolescent↗

PubMed2001

Portal-systemic myelopathy after transjugular intrahepatic portosystemic shunt creation: report of four cases.

The authors attempted to describe the clinical manifestations of portal-systemic myelopathy (PSM) after transjugular intrahepatic portosystemic shunt (TIPS) creation. PSM was developed in four of 212 (1.89%) patients who underwent TIPS procedures in our hospital. Three men and one woman, ranging in age from 41 to 56 years, with a history of posthepatitis cirrhosis and recurrent bleeding from gastroesophageal varices had intrahepatic shunts created with 10-mm-diameter Wallstents. Shunt patency was confirmed by color Doppler ultrasonography (US) in each patient after TIPS creation. Progressive spastic paraparesis involving the lower extremities occurred between 5 weeks and 5 months after TIPS creation in the four patients. Neurologic examination showed evidence of spasticity in all cases, with ankle clonus, extensor plantar responses, and lower extremity hyperreflexia. All sensory modalities remained intact. Cytologic examination of cerebrospinal fluid from each patient was normal. There was no evidence of spinal cord compression on the imaging studies. PSM is a rare syndrome that includes spastic paraparesis with intact sensation. Initially noted in patients who have undergone surgical placement of a portacaval shunt, it also may occur after TIPS creation.

Adult↗

PubMed2001

Delayed complications after esophageal stent placement for treatment of malignant esophageal obstructions and esophagorespiratory fistulas.

PURPOSE: To evaluate delayed complications after esophageal expandable metallic stent placement. MATERIALS AND METHODS: From April 1993 to December 1997, 90 expandable metallic stents were placed in 82 consecutive patients with inoperable malignant esophageal obstruction (n = 49) or malignant esophagorespiratory fistula (n = 33). Stents used included covered Gianturco-Rosch Z stents (n = 20), Wallstents (covered, n = 31; uncovered, n = 13), and Ultraflex stents (covered, n = 8; uncovered, n = 10). Patients were followed prospectively and monitored for delayed complications, defined as major (hemorrhage, tracheal compression, stent migration, perforation or fistula formation, granulomatous obstruction, tumor ingrowth and overgrowth, funnel phenomenon, and stent covering disruption) or minor (reflux, chest pain, and food impaction). RESULTS: Mean survival was 4.5 months after stent placement (range, 3 weeks to 26 months). The overall incidence of delayed complications was 64.6%, with 17 patients (20.7%) experiencing more than one complication. The rates of delayed complications in patients with Z stents, Wallstents, and Ultraflex stents were 75.0%, 68.1%, and 44.4%, respectively (P <.05). Most complications were life-threatening and occurred more frequently when stents were placed in the proximal third of the esophagus, compared with more distally (P <.05). Thirteen patients (15.9%) died from complications directly related to stent placement. CONCLUSION: Esophageal stent placement for malignant obstruction or fistula is associated with a substantial incidence of delayed complications.

Aged↗

PubMed2001

Is the superior belly of the lateral pterygoid primarily a stabilizer? An EMG study.

The aim of the present study was to compare the activity levels within the two bellies of the lateral pterygoid muscle between different jaw positions to test the hypothesis that the upper head is primarily a stabilizer. Electromyographic (EMG) recordings, using monopolar concentric needle electrodes, were made from 14 healthy subjects during mandibular rest position (RP), clenching in intercuspal position and jaw opening, first about 10 mm and then about 25 mm. Both bellies had very little activity during RP. The activity level of the superior belly was high during clenching and large opening (LO) with a dip during low opening degree. This pattern differed from that of the inferior belly where the activity was relatively low during clenching and then gradually increased to its highest level during LO. The results support that the lower belly is primarily a jaw opener while the superior belly acts as a stabilizer keeping the disc and condyle in a functionally stable position during clenching and jaw movements.

Action Potentials↗

PubMed2001

Toxic emissions from mobile sources: a total fuel-cycle analysis for conventional and alternative fuel vehicles.

Mobile sources are among the largest contributors of four hazardous air pollutants--benzene, 1,3-butadiene, acetaldehyde, and formaldehyde--in urban areas. At the same time, federal and state governments are promoting the use of alternative fuel vehicles as a means to curb local air pollution. As yet, the impact of this movement toward alternative fuels with respect to toxic emissions has not been well studied. The purpose of this paper is to compare toxic emissions from vehicles operating on a variety of fuels, including reformulated gasoline (RFG), natural gas, ethanol, methanol, liquid petroleum gas (LPG), and electricity. This study uses a version of Argonne National Laboratory's Greenhouse Gas, Regulated Emissions, and Energy Use in Transportation (GREET) model, appropriately modified to estimate toxic emissions. The GREET model conducts a total fuel-cycle analysis that calculates emissions from both downstream (e.g., operation of the vehicle) and upstream (e.g., fuel production and distribution) stages of the fuel cycle. We find that almost all of the fuels studied reduce 1,3-butadiene emissions compared with conventional gasoline (CG). However, the use of ethanol in E85 (fuel made with 85% ethanol) or RFG leads to increased acetaldehyde emissions, and the use of methanol, ethanol, and compressed natural gas (CNG) may result in increased formaldehyde emissions. When the modeling results for the four air toxics are considered together with their cancer risk factors, all the fuels and vehicle technologies show air toxic emission reduction benefits.

Air Pollutants↗

PubMed2001

Accuracy and repeatability of the Yale physical activity survey in assessing physical activity of older adults.

The purpose of this study was to extend the initial evaluation of the Yale Physical Activity Survey to assess physical activity in older adults. The survey yields three indicators of physical activity reflecting activities performed during a typical week of the previous month (Total Time, Total Energy Expenditure) and the past month (Total Activity Summary Index). Questionnaire validity was studied in 56 men and women, ages 56 to 86 years, by comparing the average of 3- or 7 day 24-hr. physical activity records (n=56), predicted maximal oxygen consumption (VO2 max) (n = 23) and the sum of three skinfold measurements. Two-week repeatability was estimated by calculating an intraclass coefficient using an analysis of variance with repeated measures. Spearman rhos were used to study questionnaire validity. Analysis showed the survey was easily administered and scored and exhibited moderate-to-good repeatability. For the first administration the Total Energy Expenditure Index was significantly associated with the physical activity diary (r = .27). On the second administration, correlations were significant for the physical activity diary with the Total Energy Expenditure Index (r = .30), the Total Activity Summary Index (r = .36), and the Total Time Index (r = .27), and for VO2 max and the Total Time Index (r = .49) and Total Activity Summary Index (r = .64). Relative to the criterion measures used in this study, some validity was evident for the second administration in this relatively active and healthy sample of older adults.

Aged↗

PubMed2001

Selected lifestyle and risk behaviors associated with adolescents' smoking.

A selected number of lifestyle and risk behaviors of adolescents in relation to their smoking were studied using both longitudinal and cross-sectional analyses. Data of a national sample of 4,431 nonsmoking adolescents who participated in the 1989 Teenage Attitudes and Practices Survey and were re-interviewed in 1993 were analyzed. Adolescents who engaged in physical fights, engaged in drunk driving, and were risk-takers were more likely to be regular experimental smokers than adolescents who did not exhibit these behaviors. The data suggest that high-risk behaviors may cluster. Interventions may be necessary to target multiple risk behaviors and be more effective in changing adolescents' risk behaviors associated with smoking.

Adolescent↗

PubMed2001

The influence of significant others on attitudes, subjective norms and intentions regarding dietary supplement use among adolescent athletes.

Dietary supplement use has increased significantly over the past decade. The use of supplements among adolescents seems to be influenced by their beliefs and attitudes. The influence of coaches, parents, and athletic trainers also may be important. The purpose of this study was (1) to determine whether attitudes are a better predictor of adolescents' intentions to use dietary supplements than are subjective norms, and (2) to assess the influence of significant others (coaches, parents, and trainers) on attitudes, subjective norms, and intentions among adolescent athletes. Adolescents (N = 1,626) who were enrolled in grades six through twelve in nine public schools completed a self-report questionnaire that measured attitudes, subjective norms, and intentions regarding dietary supplement use. Results indicated that attitudes were a better predictor of intentions to use dietary supplements than were subjective norms. It was also found that trainers had more influence on the attitudes, subjective norms, and intentions of adolescents regarding supplement use than did parents and coaches. Implications for prevention are addressed.

Adolescent↗

PubMed2001

[A rapid method for the identification of four different features of gouqizi by FTIR spectrometry].

In this article, a method of using Fourier-transform infrared (FTIR) spectrometry to identify four Lyeium barbarum L. (Gouqizi) in turn of colour, shape, taste and water content. The four features (include color is red or black, shape is round or long, quality is dry or wet, taste is sweet or bitter) are related with the FTIR absorption peaks, this is based on the chemical components and their relative contents are different in various Gouqizi. These differences can be reflected in the FTIR spectra. So a new idea is brought up in the research area of identification of traditional Chinese medicine. Alao, FTIR is proved to be a rapid, simple, reliable and non-destructive qualification method.

Drugs, Chinese Herbal↗

PubMed2000

Smoking acquisition: peer influence and self-selection.

The study examined and contrasted the extent that peer influence and self-selection for smoking peers may affect acquisition of smoking by adolescents. Data for a U.S. national cohort sample of adolescents (N = 4,444) who were nonsmokers in the 1989 Teenage Attitudes and Practices Surveys and were re-interviewed in 1993 were included. The information included measures of smoking behavior and smoking status of both boys' and girls' best friends. Analysis demonstrated that, although the effects of both peer influence and self-selection of smoking friends occurred, self-selection may play a greater role in adolescents' beginning to smoke. This implies that, while teaching adolescents to resist peer pressure may be necessary, it is perhaps more important to identify factors that influence adolescents' decisions in choosing friends who smoke. This could lead to more effective preventive strategies.

Adolescent↗

PubMed2000

Drug use and HIV risk--related sex behaviors: a street outreach study of black adults.

BACKGROUND: Our street outreach project investigated the relationship between use of noninjecting drugs (alcohol, marijuana, cocaine) and human immunodeficiency virus (HIV) risk-related sex behaviors of black adults. The study focused on three HIV-related risks: multiple sex partners, unprotected sex, and drugs during sex. METHODS: Data for this study were collected in a street outreach community survey for a drug abuse and HIV intervention study in Birmingham, Ala. A total of 780 black men and women completed the survey. RESULTS: High-risk sex behaviors were far more prevalent among cocaine users than marijuana or alcohol users. A greater number of cocaine users reported having multiple sex partners, not using condoms, and using drugs during sex. Female cocaine users showed the same risk level for HIV infection as male cocaine users. CONCLUSIONS: Increased risk of HIV infection through sexual transmission is associated with use of noninjecting cocaine for both men and women. Condom use should be considered as a major component of HIV prevention programs.

Adult↗

PubMed2000

[Affect of heredity, disease and environment on the life-span of personage in History Book of Song Dynasty].

The data have been sorted and calculated by statistics for personages' life-span according to surname and Yin-Yang type and disease according to the cause of pattern over 793 personage from the biography of emperor families' and official in feudal times and subjects of the feudal ruler in History Book of Song Dynasty. (1) For there are some genetic diseases causing their earlier death in surname Zhao's, the average value of life-span is shorter than the other surname of Wang, Li, Zhang, Liu and Chen's. Because the average value among those five surnames are not different each other, the character of the distribution of every one's tally with neuter alleles. (2) The average value in a population on a type of mild Yin and Yang is higher than the type of Yang only, P < 0.05. (3) Disease and bad environment are the limiting factors for life. Besides, to rise the resistance ability is an important path way for increasing our life-span. The attribute of a genetic system in Yin or Yang is an objective existence. Influence on life by genetics may vary with various disease and environment, but different disease is controlled genetically. A bad environment may affect life, but neuter environment would be affected the life through attribute of a genetic system in Yin or Yang type indirectly.

Environment↗

PubMed1999

Prospective social-psychological factors of adolescent smoking progression.

PURPOSE: To evaluate the ability of social-psychological risk factors to predict adolescent smoking behavior. METHODS: Nonsmoking adolescents (n = 4032) who participated in the 1989 and 1993 Teenage Attitudes and Practices Surveys (TAPS I) were selected for analyses. Four multivariate logistic models were used to examine (a) adolescents' smoking initiation, (b) adults' smoking initiation, (c) adolescents' progression to regular smoking, and (d) adults' progression to regular smoking. A series of social-psychological variables were measured. RESULTS: All four models were significant. However, no social-psychological factors were consistently significant in all four models, except white ethnicity. Data showed that social-psychological factors are less able to predict the transition from nonsmoking to experimental smoking than that from nonsmoking to regular smoking. CONCLUSIONS: Future prospective studies should measure both social-psychological and smoking acquisition factors at closer intervals to more accurately examine potential relationships.

Adolescent↗

PubMed1999

AIDS knowledge among black drug users: an issue of reliability.

This study examined the reliability of an inventory measuring AIDS-related knowledge among 553 black drug users. Data were collected from a socially high-risk community in Birmingham, Alabama. The KR-20 reliability scores were computed from the inventory for each drug-use group. The KR-20 reliabilities ranged from .39 to .57. These findings may suggest that the inconsistent reports of the predictive power of AIDS knowledge among drug users reported in previous studies might be related to the low internal consistencies of the inventory.

Acquired Immunodeficiency Syndrome↗

PubMed1998

Risk factors for hip fracture among southern older women.

BACKGROUND: Older women are considered at risk for hip fracture; fracture rates are highest in the southern region of the United States. The purpose of this study was to develop a predictive model for osteoporotic hip fracture among a national sample of southern women aged 50 years and older. METHODS: Subjects were participants in the Third National Health and Nutritional Examination Survey, Phase 1. Data were collected by the National Center for Health Statistics. Predictors examined included age, race, heredity, body mass index, physical activity, smoking status, alcohol use, and dairy product use. RESULTS: The sample consisted of 953 women aged 50 years and older. The predictive model included older age, black race, Hispanic race, and low body mass index. CONCLUSIONS: Recommendations emphasize weight gain for underweight women and promotion of healthy body weights for women of all ages.

Aged↗

PubMed1998

Osteoporotic fracture among older U.S. women: risk factors quantified.

The purpose of this study was to develop a predictive model for osteoporotic fracture among a national sample of 2,325 women ages 50 years and older. Predictors for examination included age, race, heredity, body mass index (BMI), physical activity, smoking status, alcohol use, and dairy product use. Analyses were conducted using Standard Analysis System (SAS) procedures. Strong risk factors predicting osteoporotic fracture included age, race, low BMI, and inactivity. Recommendations emphasize screening of high-risk women, achieving and maintaining health body weights for underweight women, and obtaining moderate physical activity. Promotion of healthy body weights for women of all ages is emphasized. Recommendations also include encouraging widespread physician, patient, and public education regarding osteoporotic fracture.

Activities of Daily Living↗