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Biomedical subjects

M R Alderson

Publications and source records attributed to M R Alderson.

At least 91 records · Page 5Linked to original sources
PubMed1981

Radical versus modified radical mastectomy for breast cancer.

A prospective randomised trial (534 patients, 1969-75) was designed to determine whether radical mastectomy conferred advantages over modified radical mastectomy for breast cancer in terms of total survival, local recurrence, distant metastasis, and disease-free interval. The results showed no significant difference in outcome as regards these variables between the two treatments.

Breast Neoplasms↗
PubMed1980

Mortality of workers on an isopropyl alcohol plant and two MEK dewaxing plants.

An historical prospective study was undertaken of 262 men who had worked on an isopropyl alcohol plant and 446 men who had worked on two MEK dewaxing plants. All of the former have been traced, and only one man from the latter group was lost to follow-up. These studies linked occupational records with cause of death data for those who had died; the average follow-up was 15.5 years for the IPA plant workers and 13.9 years for those on the MEK dewaxing plants. For the IPA workers the observed deaths (26) were slightly above the expected (23.6), and there was a non-significant excess of deaths from neoplasms (0 = 9, E = 6.19). One person died from nasal cancer (E = 0.02, p = 0.017); though based on small numbers this finding is unlikely to be due to chance and agrees with the original hazard. For those who had worked on the MEK dewaxing plants the observed deaths (46) were below the expected (55.51) and there was also a slight deficiency of deaths from neoplasms (0 = 13, E = 14.26). When the seven sites of malignancy, which had been examined in a recent American study, were compared there were significantly more deaths from buccal cavity and pharynx cancers (0 = 2; E = 0.13; p = 0.008) and significantly fewer from lung cancer (0 = 1; E = 6.02; p less than 0.045). After reviewing the American and present results, it was concluded that there is no clear evidence of a cancer hazard in these workers, though further follow-up of larger numbers is necessary for a more precise estimate of the confidence limits of these findings.

1-Propanol↗
PubMed1976

Death from ischaemic heart-disease and malignancy in adult patients with coeliac disease.

The cause of death was obtained for 77 members of the Coeliac Society resident in England and Wales. Proportional mortality analysis revealed a significant deficiency in deaths from ischaemic heart-disease in males and a non-significant deficiency in females. It is suggested that this apparent protective effect of coeliac disease might result from malabsorption of dietary lipids. The study also confirmed findings of an excess of deaths from lymphoma and upper gastrointestinal neoplasms.

Celiac Disease↗
PubMed1976

Prophylaxis in haemophilia: a double-blind controlled trial.

A double-blind controlled trial of prophylactic factor VIII therapy has been carried out on nine severe haemophiliacs at the Lord Mayor Treloar College. Infusions were given once weekly and calculated to give a post-infusion plasma concentration of at least 0.25 I.U./ml of factor VIII. This regime reduced the overall bleeding frequency by 15%. The bleeding frequency in the first 3 days post-infusion was reduced by 66%. A moderate overall reduction in morbidity was also achieved. It is calculated that to reduce the incidence of bleeding in severe haemophiliacs by 15% would require a 73% increased usage of therapeutic materials. More than twice this amount of material is likely to be needed to reduce the bleeding frequency of the same group by 66%.

Adolescent↗
PubMed1973

Confidentiality.

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Data Display↗
PubMed1973

Care of the dying.

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Hospitalization↗
PubMed1971

The relative significance of prognostic factors in breast carcinoma.

A retrospective detailed study of 272 cases of breast carcinoma treated by radical mastectomy was published by Hamlin (1968). An extended analysis of the material for 258 of these cases is now reported.Data for 21 prognostic factors from 258 patients have been subjected to multiple regression analysis to determine the independent effect and thus the relative importance of each factor. The findings confirm previous single factor analyses and demonstrate that nine of the factors are independently associated with survival.Mathematical manipulation of the information obtained in this analysis allowed a risk score to be allotted to each patient. Grouping of patients by the prediction scores is found in this series to be more closely related to survival than is clinical staging of the same patients.

Age Factors↗
PubMed1971

The British system for anticoagulant control and Thrombotest.

A study has been made to determine whether a reliable comparison can be made between the British Comparative Thromboplastin and Thrombotest using the nationally adopted standardization procedure. The method recommended appeared sufficiently satisfactory and statistically valid for the comparison between the British Comparative Thromboplastin and Thrombotest. The degree of diversion in the location of the ;best lines', which should have been in an identical position at each centre, suggests that the standardization procedure at individual hospitals with Thrombotest is not usually a sufficiently reliable basis for clinical anticoagulant dosage. The degree of diversion almost certainly arises from technical error in the standardization procedure, and it is suggested that Thrombotest should be calibrated against the British Comparative Thromboplastin only in specialist coagulation centres thoroughly conversant with both techniques.

Anticoagulants↗