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Biomedical subjects

M R Baker

Publications and source records attributed to M R Baker.

At least 19 recordsLinked to original sources
PubMed1992

The effect of tensile strength on the clinical effectiveness and patient acceptance of dental floss.

This study compared the clinical effectiveness and subjective approval of 2 waxed dental flosses that differed significantly in tensile strength and wax content. At the initial appointment, subjects (20 1st-year dental students) were instructed to stop interproximal cleaning on 2 contralateral quadrants in order to allow plaque to accumulate on these surfaces for 1 week. 1 week later, subjects were instructed to begin flossing these 2 contralateral quadrants with 1 of the 2 types of floss for the next 1-week period, while withdrawing interproximal cleaning on the opposite 2 contralateral quadrants. After flossing these 2 quadrants for 1 week, the subjects began flossing the opposite 2 contralateral quadrants with the same floss. After 2 weeks of flossing contralateral quadrants, the 1st floss was withdrawn and replaced with the alternative floss for another similar 2-week trial period. At the end of each 2-week trial period, subjects completed subjective questionnaires concerning the floss they had used during the previous 2-week period. Pre- and post-flossing plaque indices were calculated for each week for both flosses, and compared statistically by a repeated measures analysis of variance. The results showed that both flosses significantly reduced interproximal plaque deposits, and had equal subjective approval. However, neither the greater-strength nor the lower-wax content of the experimental floss was associated with an increase in clinical effectiveness or with a change in subjective approval.

Adult↗
PubMed1992

Insulin resistance, diabetes, and risk markers for ischaemic heart disease in Asian men and non-Asian in Bradford.

OBJECTIVE: To examine the hypothesis, in a community not studied before, that insulin resistance associated with centralised adiposity is the mechanism underlying the predisposition of Asian immigrant communities to both ischaemic heart disease and diabetes mellitus. DESIGN: Cross sectional study within one socioeconomic stratum. SETTING: Two factories in the textile sector in Bradford, West Yorkshire. SUBJECTS: Male manual workers of Asian (110) and non-Asian origin (156) aged 20-65 years. RESULTS: Diabetes was almost three times more prevalent in the Asian group. Two hours after an oral glucose load Asian men had double the serum insulin concentrations of non-Asian men (p < 0.0001). Asian men also had significantly lower concentrations of plasma total cholesterol (p < 0.03), high density lipoprotein cholesterol (HDL) (HDL2, p < 0.0001; HDL3, p < 0.0001), and apolipoprotein AI (p < 0.0001). Fasting plasma triglyceride concentrations were slightly higher (p = 0.072) in the Asian men; thus the ratio of triglyceride cholesterol was higher (p = 0.006). The inter-relation between serum insulin and plasma lipid concentrations indicated metabolic differences between the ethnic groups. Insulin concentrations were associated with cholesterol concentrations in the Asian men only and there was a lack of association between triglyceride, low density lipoprotein cholesterol, and HDL cholesterol in this group. The risk marker profile in the Asian men was therefore quite different to that of their non-Asian counterparts and was associated with a greater tendency to centralised adiposity. CONCLUSION: These data support the insulin resistance hypothesis and thus have important implications for strategies for the prevention of heart disease in Asian communities in the United Kingdom.

Adult↗
PubMed1991

Immunoscintigraphy of colorectal carcinoma utilizing 111In-labeled monoclonal antibody conjugate CYT-103.

Twelve presurgical patients with colorectal carcinoma received a single intravenous infusion of 0.5-20.0 mg of the radiolabeled monoclonal antibody conjugate CYT-103. This product is an immunoconjugate of B72.3 labeled with Indium-111 (111In). Patients underwent preoperative gamma camera imaging and computed tomographic (CT) scanning of the abdomen and pelvis. Fifteen intraabdominal sites of tumor were found at surgery. Monoclonal antibody imaging detected 87% of these lesions, whereas CT of the abdomen and pelvis detected 47%. Monoclonal antibody imaging identified tumor in 27% of the patients in which CT did not identify any sites of tumor. The results of this study indicate that monoclonal antibody imaging using [111In]CYT-103 is useful for the preoperative evaluation of colorectal carcinoma patients and the results are complimentary to CT of the abdomen and the pelvis.

Adult↗
PubMed1991

General practitioners' perceptions of Asian and non-Asian patients.

The literature on the health of the population of Asian origin contains little on their interaction with primary care services. This paper reports results of a postal survey of GPs' attitudes towards Asian and Non-Asian patients. The response rate was 78%-141 of the 182 GPs replied. Compared with non-Asian patients, GPs held less positive attitudes towards Asian origin patients who were thought to require longer for consultations, be less compliant, and make excessive and inappropriate use of health services. These perceptions have implications for patient care and the GP workload.

Adult↗
PubMed1991

Patients' choice of general practitioner: importance of patients' and doctors' sex and ethnicity.

The relative importance of sex and ethnicity in patients' choice of doctor is not known. A total of 1633 consultations at a health centre in Bradford, with a mixed ethnic list, were examined over a four week period to test the relative importance of these variables. Patients had the choice to consult any one of: a male Asian, a male white or a female white doctor. Asian patients, irrespective of sex, were significantly (P less than 0.001) more likely to consult the Asian doctor then either of the other two doctors, though a greater proportion of Asian women than men consulted the female white doctor. Although the sex of the doctor was important in patients' choice, for Asian patients the doctor's culture and language were more important.

Asia↗
PubMed1990

Incidence of cancer in Bradford Asians.

STUDY OBJECTIVE: The aim of the study was to investigate the incidence of cancer in Asians living in Bradford. DESIGN: Cancer registrations were obtained from the Yorkshire Regional Cancer Registry for the six year period 1979-1984. Registrations relating to persons of Asian background were extracted using forenames and surnames. Data were analysed by disease category and age and sex specific incidence rates were calculated. These were compared with expected incidence rates for the non-Asian population and with rates for the Indian subcontinent derived from the Bombay Cancer Registry. SETTING: Data collection was confined to the Bradford Metropolitan District, population 449,897 (1981). SUBJECTS: The Asians studied originated from Pakistan (65%), India (28%), Bangladesh (4%), and East Africa (3%). The total Asian population of the Bradford Metropolitan District was approximately 45,000. MAIN RESULTS: Over the study period there were 178 Asian cancer registrations. The overall standardised registration ratio was 53.7 for males (100 cases, 95% confidence interval 43-64), and 43.5 for females (78 cases, 95% CI 34-53). The standardised registration ratios for cancer of the hypopharynx in males and gall bladder in females were significantly raised. There was a particularly low incidence of cancer of the stomach, large bowel, lung, skin, and bladder in males, and of skin, breast, cervix (in situ), and ovary in females. The analyses suggested that lung and breast cancer incidence may be increasing towards the non-Asian level. In situ cancer of cervix in Asians shows no evidence of the high rates found in younger non-Asian age groups. CONCLUSIONS: Lower incidence of many cancers in Asians may be due to lower exposure to major risk factors. Demographic change resulting in increased exposure to these risk factors can be expected to result in an increase in cancer incidence in Asians.

Age Factors↗
PubMed1989

Health of British Asians; a research review.

About 2.5 per cent of United Kingdom residents are of Asian (or Indian subcontinent) origin though the term 'Asian' hides their internal diversities of languages, religions and national origins. The research on the health of these populations is heavily concentrated in areas of rickets and osteomalacia, tuberculosis, maternal and child health, and mental health, and is mainly dependent on analysis of routinely available morbidity and mortality data. Little has been published on the use of primary care services, racism in health service delivery, quality of care and doctor-patient communication. Also, few of the studies have attempted to interpret their findings against the disadvantaged background of Asian communities. It is implied that differences in health status are due to linguistic and cultural factors alone. The research literature on the health of Asian populations is critically reviewed.

Adolescent↗
PubMed1989

Influence of ethnicity and unemployment on the perceived health of a sample of general practice attenders.

Published research shows people of Asian origin to be less healthy than the white population. Most of the studies have not taken account of differences in employment between populations of white and Asian origin. Also, little research has been carried out on the patients' perceived health. This study, based on 215 patients from an inner-city general practice in Bradford, looks at the influence of ethnicity and unemployment on the perceived health of the sample. The Nottingham Health Profile was used as the measure of perceived health. In the study population, twice as many Asians as white people were unemployed, and significant differences in perceived health were observed between the employed and the unemployed. After controlling for employment, Asian males had significantly better perceived health than white males in the 16-34 age group. Perceived health of Asian and white females was similar on most morbidity dimensions.

Adolescent↗
PubMed1989

The effects of single doses of X rays on the mechanical properties of pig skin in vivo.

Changes in the mechanical properties of pig skin have been studied in vivo, using a dermal extensometer, after irradiation with a single dose of 18 Gy of X rays. There was no significant change in the stiffness of irradiated skin, when compared with unirradiated skin, until 9 weeks after irradiation when the irradiated skin was significantly stiffer. This effect was also found at 12 and 15 weeks after irradiation. When the increase in skin thickness, as a consequence of oedema, was taken into account a significant increase in the unrelaxed elastic modulus of irradiated skin was only seen at 12 and 15 weeks after irradiation. There were no significant changes in force relaxation, after extension of the skin, over this time period. After the resolution of oedema, which was associated with a significant 20% reduction in the thickness of irradiated skin relative to unirradiated skin, the mechanical properties of irradiated skin were not markedly different from those of unirradiated skin. However, between 30 and 39 weeks after irradiation there was a further wave of dermal thinning, resulting in a total reduction in the thickness of irradiated skin relative to unirradiated skin of 26%. This was associated with a rapid rise in the skin stiffness and unrelaxed elastic modulus by approximately 65 and approximately 140%, respectively. It was only at these late times after irradiation that the force relaxation of the skin was modified significantly. At 9 and 12 weeks after irradiation the reduction in skin stiffness and the unrelaxed elastic modulus were dose related. Based on the percentage of fields showing a significant reduction in these biomechanical parameters, ED50 values of between 12 and 14.5 Gy were established. This would appear to be a sensitive method for assessing radiation-induced dermal changes since few gross changes are observed in this dose range.

Animals↗
PubMed1989

Patients' choice of general practitioner: influence of patients' fluency in English and the ethnicity and sex of the doctor.

Asian patients' use of general practitioner services and, in particular, their interaction with doctors is not well researched. However, difficulty in communication and in the case of women, reluctance to be examined by a male doctor has been reported. This study, based on interviews with 241 Caucasian, Pakistani and Indian patients attending a general practice in Bradford, examined the relationship between choice of general practitioner and the patient's fluency in English and the general practitioner's ethnicity and sex. Both Pakistani and Indian patients, particularly women, had poor fluency in English and the use of interpreters was confined to women (11% of Pakistani women and 4% of Indian women). The linguistic and broad cultural concordance between the patient and the general practitioner was more important in the choice of doctor than the sex of the general practitioner. It was also found that while 62% of Pakistani women objected to being examined by a male doctor, this was true for only 21% of Indian women.

Asia↗
PubMed1979

Two cases of the nephrotic syndrome with a reversible coagulation defect.

Two cases of the nephrotic syndrome with an apparently identical defect of blood coagulation, discovered during preparation for renal biopsy are described. Plasma from both patients showed prolongation of thrombin and kaolin cephalin times which was probably due to abnormally slow polymerization of fibrin monomer. Corticosteroid therapy reversed the abnormal times in one case. One of the patients showed seasonal relapses which occurred in relation to episodes of hay fever associated with allergy to grass pollen. The other patient showed some similar features, but on renal biopsy was found to have proliferative glomerulonephritis.

Adult↗
PubMed1979

Redescription of Camallanus ancylodirus Ward and Magath 1916 (nematoda: Camallanidae) from freshwater fishes of North America.

Camallanus ancylodirus Ward and Magath 1916 is redescribed, based on examination of syntypes. This species differs from C. oxycephalus Ward and Magath 1916, the only other camallanid described from freshwater fishes of North America, in the size of male worms, number and arrangement of caudal papillae in males, shape of the male caudal end, position of the vulva, and length and shape of the female tail. The host range of C. ancylodirus is not clear from literature reports because the species may have been confused with C. oxycephalus.

Animals↗