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Biomedical subjects

M R Caccia

Publications and source records attributed to M R Caccia.

54 records · Page 3Linked to original sources
PubMedDate not supplied

Morphology and physiology of skeletal muscle in aging rodents.

Aging in the rodent is accompanied by a progressive loss of skeletal muscle fibers. The muscle twitch also becomes slower, probably as a result of fiber-type conversion from "fast-twitch" to "slow-twitch." The loss of muscle fibers precedes signs of obvious weakness and appears to involve the loss of entire functioning motor units. In the mouse, this loss of motor units correlated with a loss of axons from the innervating nerve trunks.

Adenosine Triphosphatases↗
PubMedDate not supplied

Treatment of denervated muscle by gangliosides.

Short-duration cooling of the nerve to the extensor digitorum longus muscle of the rat in vivo induced partially reversible denervation of the muscle and atrophy in the type 2 muscle fibers. Increases in cyclic adenosine monophosphate, cyclic guanosine monophosphate phosphodiesterase, adenylate cyclase, and guanylate cyclase were observed in the denervated muscle. Treatment with gangliosides of the bovine brain cortex seemed to improve the excitability of the surviving motor units and to encourage recovery of neuromuscular trophic control, but it did not affect the nerve conduction velocity or the contractile properties of the denervated muscle.

Animals↗
PubMedDate not supplied

Nerve conduction velocity distribution in normal subjects and in diabetic patients without clinical neuropathy. I. Motor nerve.

A computer-assisted collision method to evaluate motor conduction velocity distribution of the ulnar and external peroneal nerves in normal subjects and in insulin-dependent and non-insulin-dependent diabetics without clinical signs of neuropathy is described. Distribution curves were sigmoidally (bimodally) shaped in normal and in insulin- and non-insulin-dependent subjects. In insulin-dependent patients, motor conduction velocity of the peroneal nerves was globally impaired, whereas of the ulnar nerves it was normal. In non-insulin-dependent patients, slower conduction velocity was involved in both nerves.

Action Potentials↗
PubMedDate not supplied

Nerve conduction velocity distribution in normal subjects and in diabetic patients without clinical signs of neuropathy. II. Sensory nerve.

A new computer-assisted method to evaluate sensory conduction velocity distribution and dispersion of the digital nerve of the middle finger in normal subjects and in type I and type II diabetic subjects without any neurological impairment is reported. Distribution curves were exponentially shaped in normal and in diabetic subjects. In insulin-dependent diabetics, only slower conduction velocity fibers were involved, whereas no significant difference was observed between the non-insulin-dependent diabetic group and the control group.

Adult↗
PubMedDate not supplied

[Potentials of individual muscle fibers evoked by stimulation of prejunctional nerve endings in healthy subjects (preliminary observations)].

Electrical responses of the single muscle fibre (SFER) by stimulation of the motor terminal nerve-endings have been investigated in normal subjects at various ages in vivo. Shape, latency, rise-time and interspike distance seem to be SFER's most interesting parameters of the functional organisation of the motor subunits and their terminal fractions. "Time" parameters of SFER are in agreement with the anatomo-functional characteristics of the excited tissues during ageing.

Adult↗
PubMedDate not supplied

Experimental myotonia.

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2,4-Dichlorophenoxyacetic Acid↗
PubMedDate not supplied

Electrophysiology of the palmomental reflex in normal and parkinsonian subjects.

The palmomental reflex (PMR), obtained by mechanical stimulation of the skin of the thenar and hypothenar eminences of the hand and recording the surface EMG response from the chin muscles homolateral and contralateral to the side of stimulation, was studied in normal subjects and in a group of akinetic parkinsonians, both de novo and treated. PMR was present in most subjects of both groups. No differences regarding the incidence of the PMR homolateral to stimulation of the thenar eminence was found between controls and patients, and it was non-habituating in both groups. When the hypothenar eminence was stimulated, the PMR was present in about half of the subjects of both groups. PMR was present contralaterally in both normal and patients, whereas bilateral PMR prevailed in parkinsonians. Latency and duration of the reflex were significantly shorter in parkinsonians than in controls. The data are discussed in the light of the pathophysiology of the PMR putative pathways in normal subjects and in Parkinson's disease.

Afferent Pathways↗