A rapid assay for polypeptide chain termination.
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Amino Acid Sequence↗
Biomedical subjects
M R Capecchi
Publications and source records attributed to M R Capecchi.
Polypeptide chain termination in vitro: isolation of a release factor.
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Carbon Isotopes↗
Cell-free protein synthesis programmed with R17 RNA: identification of two phage proteins.
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Autoradiography↗
Fractionation of a suppressor sRNA.
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Carbon Isotopes↗
N-formylmethionyl-sRNA as the initiator of protein synthesis.
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Bacterial Proteins↗
Initiation of E. coli proteins.
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Alanine↗
Protein synthesis directed by DNA phage messengers.
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Bacterial Proteins↗
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.
Injection of homologous DNA sequences into nuclei of cultured mammalian cells induces mutations in the cognate chromosomal gene. It appears that these mutations result from incorrect repair of a heteroduplex formed between the introduced and the chromosomal sequence. This phenomenon is termed 'heteroduplex induced mutagenesis'. The high frequency of these events suggests that this method may prove useful for introducing mutations into specific mammalian genes.
Animals↗