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Biomedical subjects

M R Chaudhry

Publications and source records attributed to M R Chaudhry.

At least 19 recordsLinked to original sources
PubMed1999

The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses.

Twelve subjects were treated with zidovudine, lamivudine, and ritonavir within 90 days of onset of symptoms of acute infection to determine whether human immunodeficiency virus type 1 (HIV-1) infection could be eradicated from an infected host. In adherent subjects, with or without modifications due to intolerance, viral replication was suppressed during the 24-month treatment period. Durable suppression reduced levels of HIV-1-specific antibodies and cytotoxic T lymphocyte responses in selected subjects. Proviral DNA in mononuclear cells uniformly persisted. The persistence of HIV-1 RNA expression in lymphoid tissues and peripheral blood mononuclear cells suggests that elimination of this residual pool of virus should be achieved before considering adjustments in antiretroviral therapeutic regimens. In addition, given the reduction in levels of virus-specific immune responses, it would seem prudent to consider enhancing these responses using vaccine strategies prior to the withdrawal of antiviral therapy.

Acquired Immunodeficiency Syndrome↗
PubMed1996

Rhinomanometric evaluation of the improved mechanical therapeutic nasal dilator in patients with anterior nasal obstruction.

The effectiveness of the Improved Mechanical Therapeutic Nasal Dilator (IMTND) was evaluated rhinomanometrically in 33 patients (mean age: 26 years; range 18-68 years) with anterior nasal obstruction. Using anterior rhinomanometry the patients were observed to have a mean total resistance of 0.376 Pa/cm3/s (range: 0.16-0.87 Pa/cm3/s). There was a significant drop in the inspiratory nasal resistance by 26% after the insertion of the IMTND in the nostrils (p < 0.001). Following decongestion with 1% phenylephrine the resistance decreased by 41%. This difference was statistically significant (p < 0.001). Insertion of the IMTND in the decongested nostrils resulted in even higher and significant decrease in the nasal resistance by 59% (p < 0.001).

Administration, Intranasal↗
PubMed1994

Neuroendocrine carcinoma of the ethmoid sinus.

The paranasal sinuses are a rare site for neuroendocrine carcinoma (NEC). In contrast to the other regions, NEC of the sinuses has been reported to be recurrent and locally destructive. We report a case of NEC of the ethmoid sinuses. The patient was a 16-year-old Indian boy and was treated with radiation therapy to 6500 rad. He has been disease free for the past 5 years. All the cases reported to date were also reviewed.

Adolescent↗
PubMed1994

Ear lobe keloids, surgical excision followed by radiation therapy: a 10-year experience.

This retrospective study was conducted to analyze the recurrence of ear lobe keloids in 36 patients after surgical excision followed by radiation therapy. In all the cases keloids were excised and the surgical wound closed primarily. Following surgery, patients underwent 1800 cGy of radiation therapy in three equally divided doses over five to seven days. Most of our patients were young black females who developed keloids secondary to ear lobe piercing. Of the 36 patients followed for a mean period of 5.6 years, we noted only one (2.8%) recurrence. All the patients were followed for a minimum of two years. No serious complications were observed in our series. However, one patient developed radiation dermatitis followed by patchy hypopigmentation. We conclude that surgical excision followed by radiation therapy is a safe and effective method to control keloid recurrence in the ear lobe region.

Adult↗
PubMed1993

Incompatibility of Isovue 370 and papaverine in peripheral arteriography.

Complete thrombotic occlusion of the arterial blood flow in the upper extremity was produced after mixture of Isovue 370 (iopamidol) and papaverine hydrochloride during routine angiography. Bolus and then continuous infusion of urokinase failed to dissolve the thrombus. The patient required a surgical thrombectomy and recovered uneventfully. This case report demonstrates that caution should be exercised when Isovue 370 and papaverine are used in angiography.

Angiography↗
PubMed1993

Agrotherapy--new concept of rehabilitation for chronic schizophrenics in Pakistan.

The provision of comprehensive programme for mental health in the community setting has achieved an important place in the field of psychiatric rehabilitation. The concept of agrotherapy which is based on the philosophy of keeping patients occupied in a rural and agricultural setting with more structured activities has been found to be a promising innovation for the rehabilitation of chronic schizophrenics in this regard. This paper describes the results of a three years follow-up study conducted at Fountain House Farm, Farooqabad to evaluate the effectiveness of agrotherapy. The findings are discussed in terms of practical implications of this innovative approach in the rehabilitation of chronic schizophrenic patients.

Adult↗