Practical issues in obtaining child assent for research.
This article describes ways to engage children in clinical research through a carefully planned assent process. When assent is handled well, children may gain a sense of control over their choice to participate in research, which may in turn enhance their cooperation in the process. Ways to engage children in the assent process, the historical development of consent and assent, and discussion of the issues surrounding parental consent and child assent are presented. Practical suggestions are provided to make research participation a positive and appealing process for children.