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Biomedical subjects

M R Isaev

Publications and source records attributed to M R Isaev.

At least 19 recordsLinked to original sources
PubMed1983

[Various aspects of the pathogenesis of the postischemic syndrome].

The contribution of some regulatory humoral systems (sympathoadrenal, pituitary-adrenal, kallikrein-kinin and renin-angiotensin ones) to the development of postischemic hemodynamic disorders associated with acute arterial occlusion are demonstrated. Pathogenetic rationale is offered for methods of postischemic cardiovascular functional disorders control (the use of antienzyme drugs, cortisol, tocopherol on days 1-3 of the postischemic period).

Adrenal Medulla↗
PubMed1983

[Venous thrombosis and its complications in patients with acute arterial occlusion].

The authors have studied the incidence of deep venous thromboses and embolism of pulmonary artery branches in patients with acute arterial occlusion. Autopsies of 1279 patients with acute arterial occlusion have revealed thrombosis of main veins in 219 patients (17,1%), embolism of the pulmonary artery branches--in 132 patients (10,3%), thromboembolism of pulmonary arteries being diagnosed in life time in 19 patients only (14,4%). Venous thrombosis was revealed in 25 of 33 patients with acute arterial occlusion by distal phlebography, retrograde iliocavagraphy or radioisotopic phlebography. In 5 patients with floating thrombosis of the iliac or inferior caval vein umbrella cava-filters were implanted in order to prevent an embolism of the pulmonary artery. The investigation of the venous system in patients with acute arterial occlusion is shown to be necessary.

Acute Disease↗
PubMed1982

[Sympathetico-adrenal and hypophyseal-adrenal systems in the pathogenesis of the postischemic syndrome].

The results of examination of the hypophyseal-adrenal and sympatheticoadrenal systems in 69 patients with embolism of the main limb arteries are discussed. Marked activation of these systems in this category of patients during ischemia was revealed. A discrepancy was found between the blood adrenalin and cortisol levels in patients in a definite stage of the postischemic period and their hormonal effect on the body. The need to keep a record of disorders of the mechanisms of neurohumoral regulation in correcting the cardiovascular function in patients with acute arterial obstruction is emphasized.

Acute Disease↗
PubMed1982

[The hemostatic system in acute occlusion of the major arteries].

The system of the haemostasis in acute occlusion of the main arteries is characterized by a combination of hypercoagulation, arrest of fibrinolysis, and increase of the adhesive-aggregation function of the formed elements of the blood. The age, aetiology, localisation and the character of arterial occlusion, the degree, and the duration of ischaemia of the tissues influence the degree of the above disorders. The above factors must be taken into consideration in choosing methods of the antithrombotic therapy of thromboembolic lesions of the main arteries. The main principle of such therapy is simultaneous corrections of the disorders of haemocoagulation, fibrinolysis, adhesion, and aggregation of the formed elements of the blood by the combined use of anticoagulants, fibrinolytic and antiaggregation drugs.

Acute Disease↗
PubMed1979

[Renin-angiotensin-aldosterone system in acute embologenic arterial obstruction].

Examination of patients with acute embologenic arterial occlusion yielded data testifying to activation of the renin-angiotensin-aldosterone system both in the ischemic and in the postischemic periods. Direct dependence of the activation of the renin-angiotensin-aldosterone system on the degree of tissue ischemia and duration of the ischemic period of up to 2 days was revealed. The development of secondary hyperaldosteronism in patients with embolism of the major vessels stipulated the expediency of using aldosterone antagonists in patients with most marked ischemic changes in the tissues as well as when the ischemic period lasted more than 6 hours.

Acute Disease↗
PubMed1979

[Use of correlation analysis of clinical biochemical indices for a study of the pathogenesis of acute arterial obstruction].

The role of serotonin, histamine, and the kallikrein-kinin system in acute arterial occlusion during ischemia was studied from the standpoint of multivariate correlation analysis. The mechanisms of their participation in the genesis of pathophysiological disorders in the organism in acute arterial occlusion are discussed. The important role of serotonin and the kallikrein inhibitor in this pathological condition is shown.

Acute Disease↗
PubMed1978

[Pulmonary embolisms as a complication of acute arterial obstruction of the lower extremities].

This is an analysis of 130 cases with embolism of the pulmonary artery with a lethal outcome, which had developed in patients suffering from occlusion of the lower extremities. It is noted that the origin of embolism of the system of the pulmonary artery depends on the severity of ischemia of the tissues of the affected extremity and pointed out that this menacing complication develops both in the stage of ischemia and in the postischemic period. For the prevention of pulmonary embolism in patients with severe ischemia or gangrene of the lower extremities, it is recommended that operative treatment (corrective operations on the arteries or amputation) should be combined with inspection of the major veins.

Acute Disease↗
PubMed1975

[Functional state of the cardiovascular system in experimental acute occlusion of the terminal segment of the aorta].

In 30 experiments on dogs a study was conducted of the pathophysiological mechanisms of the disorders in central haemodynamics and myocardial contractility during an acute occlusion of the terminal aorta and after reestablishment of the circulation in the diseases extremities. In response to the occlusion an elevation was noted in the total peripheral resistance, in the force and rate of the cardiac contractions, and a compensatory hyperfunction of the heart developed. By 6 hours of the occlusion the total peripheral resistance increased, the force and rate of the cardiac contractions decreased, the myocardial tension increased, the external work of the heart decreased, and myocardial hypodynamy developed. In 45 min following the restoration of the circulation a reduction of the total peripheral resistance was observed, the myocardial contractility was inhibited, the phase structure of the cardiac cycle was disturbed. A further observation for 45 min failed to reveal any changes in the indices of cardio- and haemodynamics, the phase structure of the cardiac contractions and myocardial contractility, as compared to the data obtained in the preceeding study.

Acute Disease↗