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Biomedical subjects

M R Kushwaha

Publications and source records attributed to M R Kushwaha.

16 recordsLinked to original sources
PubMed1978

The problem of paralytic poliomyelitis in the urban and rural population around Lucknow, India.

A house to house survey was done from October 1972 to March 1974, covering 528952 individuals of urban population at Lucknow and 50,156 individuals of rural population of Unnao district, to find out the incidence of polio-like paralysis in our population. Among 12874 urban children up to 8 years old 8.2/1000 had polio-like paralysis while 4.6/1000 children of the rural population of 13554 children were affected. The incidence was significantly higher in the urban population. In the preschool age group almost 1 out of every 100 children was affected. A higher number of children were affected during 1968-9 and 1971-2, though it did not reach epidemic proportion. The findings show that paralytic polio is a serious problem in our country where poliomyelitis is endemic: this is contrary to the views generally held so far.

Adolescent↗
PubMedDate not supplied

Serum beta 2-microglobulin in lymphoproliferative and myeloproliferative diseases.

The serum levels of beta 2-microglobulin (beta 2m), which is the light chain moiety of the HLA (-A, -B, -C) antigens, are increased in many of the haematological malignancies. In the lymphoproliferative disorders there is generally an association between serum beta 2m and estimates of tumour load. This relationship is especially close in myelomatosis, where serum beta 2m is a powerful prognostic indicator and can be used in stratification and monitoring. Increases in serum beta 2m are also frequent in the myeloproliferative disorders, notably in myelofibrosis, and in the myelodysplastic syndromes; particularly high levels are seen in chronic myelomonocytic leukaemia. In addition to suggested cellular sources of the beta 2m in these diseases--malignant lymphoid cells and cells of the monocyte-macrophage series--the possibility that T lymphocyte sub-sets could be important contributors to the increased beta 2m production is discussed.

Hodgkin Disease↗
PubMedDate not supplied

Polymerase chain reaction vs. conventional diagnosis in fine needle aspirates of tuberculous lymph nodes.

OBJECTIVE: To compare four conventional methods of diagnosing tuberculous lymphadenophathy (TL)--namely fine needle aspiration cytology (FNAC), Zeihl-Neelsen staining of smears for acid-fast bacilli (AFB), culture for Mycobacterium tuberculosis (MTB) and lymph node biopsies--with the polymerase chain reaction (PCR) in order to assess the practicability and advantage of its use in routine diagnosis in a developing country. STUDY DESIGN: Fine needle aspirates from 142 consecutive patients presenting with lymphadenopathy (mainly cervical) without any known systemic involvement underwent cytomorphologic diagnosis, AFB smears, culture for MTB, confirmatory biopsy and PCR for MTB. The aspirates from cases other than TL served as controls for PCR. RESULTS: Correct diagnosis of tuberculosis could be made in 94.87% of cases by a combination of the four methods. PCR was done in 52 cases, 39 confirmed TL and 13 controls. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value of PCR were 94.44%, 38.23%, 44.73% and 92.85%, respectively, when culture alone was considered the gold standard. However, specificity (38.23-92.30%) and PPV (44.73-97.36%) of PCR increased remarkably when response to treatment was taken as the final arbiter. CONCLUSION: The four conventional tests were found to be the methods of choice for the diagnosis of TL in developing countries. PCR should be reserved for problem cases.

Biopsy, Needle↗