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Biomedical subjects

M R Naidu

Publications and source records attributed to M R Naidu.

16 recordsLinked to original sources
PubMed2000

Pleomorphic xanthoastrocytoma--a clinicopathological study.

Six cases of Pleomorphic Xanthoastrocytoma of central nervous system are presented. One case presented with recurrent refractory seizures and others as intracranial space occupying lesions. They were located in temporal/parietal lobes, were partly cystic and partly solid on CT scan, enhancing with contrast. Histopathology was characterized by pleomorphic giant cells and cells with vacuolated cytoplasm. Glial fibrillary acidic protein was strongly positive in all the cases.

Adolescent↗
PubMed1993

Unusual non-osseous compression at the craniovertebral junction--a report of four cases.

A variety of congenital and acquired non-osseous compression elements at the craniovertebral junction have been known and a fibrous band among them is unusual. Unaccompanied by any bony abnormality, non-osseous compression due to thickened epidural tissue, possibly congenital, presenting in adulthood is described in four cases. The onset of symptoms was in the fourth and sixth decades. Three were males and one was a female. The clinical picture was a slowly progressive spastic quadriparesis except in the only female patient who developed sudden quadriplegia while carrying a weight over her head. MR tomography was diagnostic while CT scan ruled out any bony pathology. Release of the localised epidural constriction was performed in all; in one transorally. Good recovery ensued postoperatively while histopathology excluded infective or neoplastic pathology.

Adult↗
PubMed1992

Intratumoral gamma-linoleic acid therapy of human gliomas.

In vitro and in vivo studies have shown that gamma-linoleic acid (GLA), arachidonic acid (AA) and eicosapentaenoic acid (EPA) can selectively kill tumor cells. In a clinical trial, the effectiveness of intratumoral administration of GLA in patients with gliomas was studied. Of the 6 patients treated, all showed substantial response to GLA as documented by computerized tomography. There were no acute side-effects due to the therapy. This report demonstrates that intratumoral administration of GLA is a possible approach to the treatment of human glial tumors.

Adolescent↗
PubMed1990

Tension pneumocephalus following posterior fossa surgery in sitting position. A report of 2 cases.

Tension pneumocephalus is a rare complication of posterior fossa surgery in sitting position. We encountered 2 patients with this complication amongst 60 patients operated during the past 2 years. All 60 patients had some amount of intracranial air at the end of surgery. The causative factors of tension pneumocephalus are briefly reviewed. Prompt recognition of this complication is very important. Diagnosis and management are discussed.

Child, Preschool↗
PubMed1989

Intramedullary mass lesions of the spinal cord.

Intramedullary tumors form 10% of all the spinal cord tumors. Majority of them are gliomas and rarely benign tumors are encountered. Twenty five cases of intramedullary mass lesions are studied regarding their clinical presentation, radiological features, surgical aspects and outcome following the surgery and radiotherapy. There were six benign lesions where the outcome was excellent. There were 11 patients with astrocytoma and 8 cases with ependymoma. In all, arrest of the disease or improvement could be achieved in 20 cases. Extent of surgical resection and role of radiotherapy, which are still controversial, are discussed.

Adolescent↗
PubMed1989

[Fluorotic cervical spinal cord disease].

Skeletal fluorosis was reported as a disease endemic to an area in the Madras Presidency of Indian in 1937 and prior to this, it was known as an occasional disease. There are two endemic areas in India, one in Punjab and the other in Andhra Pradesh State. This disease is also endemic in some parts of China and Africa. The manual labourers are more frequently affected as they consume huge quantities of water with high fluoride levels. The cervical spine is often affected, manifesting as cord compression. Forty cases of fluorotic cervical cord compression, who underwent surgery are studied regarding their clinical features, radiological aspects and outcome following surgery. In selected cases of cervical fluorotic myelopathy, surgical decompression appears to be necessary and also rewarding.

Adult↗
PubMed1988

Solitary thalamic abscess.

Solitary thalamic abscess is a rare entity and very few cases are reported in the literature. A case of congenital heart disease presenting with solitary thalamic abscess and successful management by simple burrhole aspiration is reported.

Adult↗
PubMed1988

Intraosseous schwannoma of the cervical spine associated with skeletal fluorosis.

Intraosseous Schwannoma of the cervical spine is very rare. Its association with skeletal fluorosis is also extremely rare. A case of successfully treated intraosseous neurofibroma of the cervical spine associated with skeletal fluorosis causing tetraparesis is reported. The clinical features, diagnostic aspects and the management is described and the literature is reviewed.

Calcinosis↗
PubMed1987

Meningiomas in childhood.

The clinical presentation and pathological characteristics of 18 histologically verified meningiomas in the paediatric age group are reviewed. There was a 1:1 sex ratio. Two children presented with seizures. The majority were supratentorial in location and large in size. In 4 patients, the meningiomas showed sarcomatous changes, while in 6 patients they were cystic.

Adolescent↗
PubMed1987

CT-findings in cystic meningiomas.

Cystic meningiomas are rare, about 10% occurring in children. Only 61 cases have been reported in the literature. Based on 6 of our own cases and the reports in the literature typical CT-findings are described and differentiating features from other cystic mass lesions discussed. If a tumour on CT shows a cystic component, is smoothly outlined, enhances markedly and is attached to the dura, then a preoperative diagnosis of cystic meningioma should be taken into account. This holds especially true if the patient is a child.

Adult↗
PubMed1987

Unilateral proptosis secondary to diffuse condensing osteomyelitis.

Osteomyelitis of the skull is an uncommon disease in the present days, mainly due to the advent of modern and more effective antibiotics. Hematogenous osteomyelitis is very rare. Osteomyelitis of the skull is usually not associated with sclerosis which is commonly seen in the rest of the skeleton. There are only few occasional case reports of condensing osteomyelitis wherein there was sclerosis of the bone associated with osteomyelitis of the skull and epidural abscess. An unusual case of diffuse condensing osteomyelitis of the skull producing unilateral proptosis is reported. The clinical, radiological features and microbiological aspects are presented. The proptosis was treated by excision of the bone behind the eyeball and thus relieving the proptosis and the impaired vision. The patient was given broad spectrum antibiotics for a period of two months. Further management problems are discussed.

Adult↗
PubMed1986

Cystic meningiomas in children.

Two cases of cystic meningioma simulating glioma, both clinically and radiologically, are reported and the literature is reviewed. The majority of cystic meningiomas in children are seen below the age of 1 year, with male preponderance. There is no relationship between cyst formation and histological type of meningioma.

Child↗