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Biomedical subjects

M R Robinson

Publications and source records attributed to M R Robinson.

118 records · Page 7Linked to original sources
PubMed1976

Experimental cellular allergic reactions in normal canine and malignant human prostate.

This paper describes the histopathology of chronic tuberculin-type hypersensitivity reactions in the normal canine and malignant human prostate. Seven dogs were sensitized by injection of Freund's complete adjuvant and the histological response to the subsequent intra-prostatic injection of 6 mg tuberculin PPD was documented. A chronic mononuclear cell prostatis persisted for 4 weeks and was accompanied by paracortical distension and follicular hyperplasia in regional lymph nodes. Six patients with carcinoma of the prostate were given multiple intraprostatic injections of BCG, which induced a chronic mononuclear cell prostatitis with some evidence of tumour-cell necrosis. The study indicated that the prostate can support chronic cell-mediated allergic reactions to extrinsic antigens and that intra-prostatic injections of BCG can be administered without harmful effects to patients with malignant prostatic disease.

Adenocarcinoma↗
PubMed1975

Plasma zinc legels in prostatic disease.

Plasma zinc concentrations rise in men over the age of 55 years and fall in women of a similar age-group. They are higher in men with clinically diagnosed benign prostatic hyperplasia, but the level does not appear to be related to the size of the gland. Plasma zinc concentrations are not helpful in the diagnosis or management of carcinoma of the prostate, but may prove useful in excluding this diagnosis.

Acid Phosphatase↗
PubMed1971

Effect of hormonal therapy on plasma testosterone levels in prostatic carcinoma.

Plasma concentrations of testosterone were estimated in normal men, in patients before treatment for prostatic cancer, and in patients who had had various forms of endocrine treatment for prostatic carcinoma. There was no decline in plasma testosterone levels with age. Patients with non-metastatic disease had levels similar to those of normal controls, but in advanced metastatic disease the levels were low. After orchidectomy the plasma testosterone level fell to that found in normal women. In every patient stilboestrol in doses as small as 1 mg three times a day suppressed plasma testosterone at first to negligible amounts, irrespective of the clinical response. Subsequently a small but significant rise in the concentration was always observed over a period of six months' oestrogen therapy. Pituitary ablation with yttrium-90 lowered the plasma testosterone concentration again to negligible amounts in patients who had been on stilboestrol. In advanced metastatic disease this was often associated with relief of pain. Preliminary studies with aminoglutethimide indicate that it can produce biochemical and clinical effects similar to those of pituitary ablation.

Age Factors↗