PubMed Health⌕ Search

Biomedical subjects

M R Sage

Publications and source records attributed to M R Sage.

At least 55 records · Page 3Linked to original sources
PubMed1990

Encephalocoele involving the petrous bone.

The rare occurrence of an encephalocoele through a defect in the tegmen of the petrous bone is reported. The case illustrates the association of this abnormality with recurrent meningitis and the importance of imaging in defining the nature and site of the lesion prior to surgery.

Adult↗
PubMed1990

Cerebral venous thrombosis in association with hormonal supplement therapy.

The administration of oestrogens is known to cause an increased risk of thrombosis in the cerebral arterial circulation. It has also been associated with cerebral venous thrombosis in patients on the contraceptive pill. We describe a case of cerebral venous thrombosis in a woman on post-menopausal hormonal therapy and discuss this with reference to the current literature.

Estrogen Replacement Therapy↗
PubMed1990

Effect of additional cations on the twitching reaction to intracarotid, nonionic contrast media in rabbits.

Previous investigations in this laboratory have confirmed the observation of facial muscle twitching during intracarotid injections of nonionic contrast media (CM) in rabbits. The reaction appears to be a locally mediated effect. To further investigate this reaction, cortical electroencephalogram (EEG) and facial electromyogram (EMG) recordings were made from rabbits receiving selective internal carotid artery (ICA) and external carotid artery (ECA) injections of CM. The effects of iopromide and iohexol were compared with and without the addition of sodium (Na) and calcium (Ca) ions at different concentrations. External carotid injections of iopromide also were performed in some animals paralyzed with D-tubocurarine to exclude the possibility that the reaction is due to an effect on peripheral nerves. The addition of between 5 and 20 mM Ca ions to both CM prevented the reaction but while the addition of Na ions (up to 150 mM) to iopromide had some preventative effect, it did not totally abolish the reaction. In those animals paralyzed with D-tubocurarine, the reaction to iopromide, as observed and recorded by EMG, was the same as that occurring in nonparalyzed animals. This finding is consistent with this reaction being independent of the peripheral nervous system.

Animals↗
PubMed1990

Factors affecting the precision of bone mineral measurements. Part 1: Review of experimentally derived results obtained from single photon absorptiometry.

An evaluation of the factors which influence the precision of bone mineral measurements using single photon absorptiometry (SPA) is presented. This incorporates several techniques which have been developed over the past few years to improve the reliability of such measurements. As such, the figures obtained should provide an objective and up-to-date basis for critical comparison with other modalities such as quantitative computerized tomography (QCT), dual photon absorptiometry (DPA) using Gd-153, and quantitative digital radiography (QDR). Under optimum conditions, a precision of 0.3% was achievable for in vitro phantom measurements. Under realistic working conditions, however, a precision of 1.0% for phantoms and 1.4% for clinical studies was found to be more typical for bone mineral content (BMC) measurements. Derived parameters such as bone mineral density (BMD) were generally less reliable, with a precision of 4.7%. It is unlikely that these values can be improved upon substantially with current SPA technology.

Absorptiometry, Photon↗
PubMed1990

Factors affecting the precision of bone mineral measurements. Part 2: Some statistical notes relating to photon counting statistics and rates of bone loss.

This paper discusses some statistical aspects of absorptiometric bone mineral measurements. In particular, the contribution of photon counting statistics to overall precision is estimated, and methods available for carrying out statistical comparisons of bone loss and determining their precision are reviewed. The use of replicate measurements as a means of improving measurement precision is also discussed.

Absorptiometry, Photon↗
PubMed1989

A randomized double-blind trial of ioversol and iopamidol in contrast-enhanced computed body tomography.

The authors compared iopamidol and ioversol in a double-blind study conducted on 81 patients (ioversol in 40 patients; iopamidol in 41 patients) undergoing computed body tomography (CT) for a variety of indications at the Flinders Medical Centre in South Australia. Each study was assessed for image quality and rated as diagnostic or nondiagnostic. Patients were monitored for blood pressure measurement, pulse rate, and respiration rate before and after contrast administration and were observed for the occurrence of side effects. Subjective assessments of heat and pain sensations also were obtained from the patients. With the exception of one patient studied with iopamidol, all investigations were rated as either good or excellent. In all cases, the examination was considered diagnostic. No adverse reactions were noted after administration of either contrast material, except in one patient who felt nauseated. Because the patient had reported feeling nauseated before the examination, this side effect was considered to be coincidental. One patient experienced mild pain from injection of iopamidol. In no cases were any drug-related or clinically significant changes in vital signs noted. In this study, both iopamidol and ioversol were well tolerated and effective, with few side effects after intravenous administration for contrast enhancement during whole-body CT.

Adult↗
PubMed1989

Cervical osteophyte induced dysphagia.

Although cervical spondylosis is a common disorder, dysphagia induced by osteophyte formation is uncommon. Fewer than one hundred cases of cervical osteophyte induced dysphagia have been reported, with little attention to the diagnosis by barium swallow. The radiological features of two cases treated surgically with good results are described. Both cases complained of dysphagia while one had associated respiratory obstruction on forward flexion of his neck. The features on barium study of cervical osteophytes causing dysphagia include deformity at the level of osteophyte formation, in both AP and lateral projections. Tracheal aspiration due to deformity at the laryngeal inlet and interference with epiglottic retroversion may be present.

Aged↗