PubMed Health⌕ Search

Biomedical subjects

M ROSENTHAL

Publications and source records attributed to M ROSENTHAL.

29 records · Page 2Linked to original sources
PubMed1954

Needle biopsy in diagnosis of prostatic cancer.

Four methods available for the diagnosis of carcinoma of the prostate-digital rectal evaluation, prostatic smear, needle biopsy and open perineal or transurethral biopsy-were studied and correlated.One hundred ten patients with clinical indications of cancer of the prostate were subjected to needle biopsy and open perineal or transurethral biopsy. Seventy of the same patients had prostatic smear examination. Using the open perineal biopsy or the positive transurethral biopsy as the standard, the accuracy of prostatic palpation, prostatic smear and needle biopsy were obtained.A high degree of correlation (74 per cent) was demonstrated between digital rectal evaluation and positive surgical biopsies in both early and late cases. There were 17 false positive clinical diagnoses. The prostatic smear showed an overall correlation of 45 per cent when compared with the results of positive surgical biopsy. The overall accuracy of needle biopsy was 73 per cent. However, in the last 39 cases, including eight in which the carcinomas were of groups A and B (curable), the needle accuracy was 100 per cent. When there is clinical indication of malignant disease of the prostate, needle biopsy of the lesion is warranted and should be done before definitive or palliative treatment is undertaken.

Biopsy↗
PubMed1949

The clinical usefulness of the vaginal smear.

The chief value of the vaginal smear is as a simple, rapid means of accelerating the diagnosis of cancer in those cases in which the presenting symptoms or lesions are not sufficiently alarming to provoke immediate surgical investigation. Carcinoma of the endocervix, carcinoma in situ, and carcinoma existing together with inflammatory and scarifying lesions are most likely to be discovered by the method. The very early ulcerative malignancy, before the fibrous proliferative reaction produces the classical raised edge and granular base, also has been detected on the smear taken just before the cautery was applied. The small nubbin without ulceration also yields malignant cells. These lesions almost always include the surface epithelium. The positive smear has induced the immediate repetition of biopsy or curettage when the first sections have not confirmed a clinical suspicion. It can prevent temporizing when there is an easy explanation (such as estrogen administration or menopausal irregularity) for spotting and metrorrhagia. Examination of smears has corrected a number of false impressions caused by poor visualization. The smear method is irreplaceable for the early diagnosis of recurrence after radiation. Salvage of the patient is rarely to be expected from such a discovery, but planning of palliative therapy is greatly aided.

Biopsy↗