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Biomedical subjects

M Radice

Publications and source records attributed to M Radice.

At least 73 records · Page 4Linked to original sources
PubMed1982

Assessment of diagnostic value of dipyridamole testing in angina pectoris.

In order to assess the diagnostic value of dipyridamole (D) testing, we studied the responses of 34 patients with chest pain and 10 normal subjects. Blood pressure and 12-lead ECG were recorded during and after intravenous infusion of 0.6 mg/kg dipyridamole for 10 minutes. Coronary arteriography and maximal or symptom-limited exercise tests were performed in the 34 patients with chest pain. During infusion 13 patients presented ischemic ST changes and 5 with anginal pain only. The latter group had normal coronary arteries. Among the 13 patients with ischemic ST changes, 7 had at least two critical coronary stenoses and the remaining 6 had no coronary lesions. Dipyridamole tests showed poor sensitivity (44%) and specificity (39%) with respect to coronary arteriography. The relatively high number of positive responses in subjects with normal coronary arteries indicates that the coronary steal phenomenon is not the sole cause of "ischemic" response to the drug. Indirect indexes of myocardial oxygen consumption were higher in patients with a positive response to drug infusion than in those with a negative response; however the value of rate-pressure product at infusion end never reached that observed at ischemic threshold during exercise testing in the same patient. This suggests that neither can oxygen consumption increase be considered as entirely responsible for ischemic response to dipyridamole. In conclusion dipyridamole test cannot be proposed for predicting critical coronary stenoses.

Adult↗
PubMed1981

[Multiple coronary spasms in asymptomatic patient (author's transl)].

A 46 year old asymptomatic male showed ST elevations in the inferior leads during an occasional basal electrocardiogram. During an ECG monitoring at rest a high number of transient episodes of ischemic type was noted: all were unrelated to symptoms. During the same session the ST segment changes appeared either in inferior leads or antero-lateral leads in different episodes. The coronary arteriography revealed absence of significant coronary stenosis and multivessel spasms: the episodes of ischemic ECG changes disappeared only during nifedipine therapy. After a 4 year follow up period no symptoms or coronary events occurred.

Angiography↗