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Biomedical subjects

M Radice

Publications and source records attributed to M Radice.

At least 109 records · Page 6Linked to original sources
PubMed1978

Placebo effect in the treatment of angina pectoris.

The interference of placebo effect in the treatment of angina pectoris has been studied in a group of patients with stable angina pectoris, selected on the basis of normal electrocardiogram at rest and a pathologic ergometric electrocardiographic test. It was found that the patients could be divided, according to the results of the exercise test, into two groups: placebo responders and place-bo-non-responders. The anti-anginal effect of beta-blocking agents has been clearly demonstrated only in the placebo-non-responders group. No statistically significant effect of beta-blocking agents was observed in the placebo-responders group. This result shows that it is necessary, in double blind trials, at first to separate placebo-responders from placebo-non responders. Otherwise the correct evaluation of a drug can be modified by the placebo-responders group.

Adult↗
PubMed1978

Antianginal and haemodynamic effects of a new beta-blocking agent, SD 1601.

Seventeen patients suffering from angina pectoris were submitted to bicycle ergometer test until an ST ischemic segment of typical pain occurred. Before and during the effort the ECG was recorded: before and after the exercise, the systolic intervals were calculated and arterial pressure measured. The T.P. index, namely the product of systolic arterial pressure by the heart rate and ejection time was calculated. The recordings and the effort test were repeated 5 min after treatment with the beta-blocking drug 1-(o-methoxyphenoxy)-3-isopropylamino-2-propanol hydrochloride (SD 1601). After treatment with the blocker, patients were able to prolong the duration of exercise or perform a higher mean total external work. SD 1601 significantly diminished O2 myocardial consumption at rest, expressed as T.P. During physical exercise, work and thus O2 consumption rise; given equal external work, SD 1601 rduces significantly O2 consumption. Acutely given, SD 1601 did not affect systolic intervals nor did it exert any negative inotropic effect.

Adrenergic beta-Antagonists↗
PubMed1978

[Presence of bites in VCGrams of a high coronary risk population (author's transl)].

The association between the presence of areas of myocardial fibrosis and the appearance of unexpected DEVIATIONS OF THE QRS loop-outline on the vectorcardiographic tracing (bites) has been reported. In order to re-evaluate the correlation between the presence of bites and the possible existence of scars we have studied 511 patients. On the basis of clinical data, laboratory data, rest and exercise electrocardiograms, the subjects have been divided into four groups; 195 normal subjects; 267 with ischemic heart disease, 16 with arterial hypertension and 33 with diabetes mellitus (the last two groups as representative of subjects with higher risk for myocardial ischemia). Bites in at least one plane were detected in 9.7% of normal subjects, 27.8% of ischemic patients, 56.3% of hypertensive patients and 18.2% of diabetics (less than 0.001). The genesis of bites and reliability of the diagnostic criteria are discussed. With more restrictive criteria the frequency in the normal subjects falls to 1%, while in the other three groups it remains much higher (10.1%-12.5%-6.1%).

Adult↗
PubMed1977

[A contribution to ergometric tests in the definition of gravity of mitral stenosis. The importance of the behavior of the left ventricular function, not always correlation to hemodynamic alterations above the valve (author's transl)].

An attempt to evaluate the severity of the valvulopathy was performed in 50 patients with pure mitral stenosis, 36 females and 14 males, by a haemodynamic study and by an exercise test. In 76% of the cases, electrocardiographic "ischemic" abnormalities were observed during the exercise test; after the exclusion of patients over 45, and patients with atrial fibrillation and/or digitalis treatment, a high frequency (63,15%) of electrocardiographic ischemic changes with effort is still observed. No correlations between the result of the exercise test either with pulmonary pressure values, or with other haemodynamic data (cardiac index and pulmonary vascular resistances) were demonstrated. The electrocardiographic abnormalities induced by exercise in these patients are discussed; the authors conclude that this behaviour under effort is significant for the importance of the impairment of the left ventricle function in mitral stenosis.

Adult↗
PubMed1977

[The bicycle electrocardiographic test for secondary prevention of coronary insufficiency. Results of a screening on 11,362 Italian workers (author's transl)].

A series of multi-phase mass screenings has been carried out in a number of working communities for locating, in their early stage, some socially important disease. The bicycle electrocardiographic test has been used for diagnostical purposes in order to single out all subjects affected by latent coronary heart disease and to evaluate the method as a means of prevention for the population. In the whole case-history, consisting of subjects free from coronary disease and with normal blood-pressure, mostly young or middle aged, the prevalence of positive electrocardiographic tests has been of 0.96%. The incidence of ischemic heart disease in 39 subjects with positive exercise test controlled after two-five years has been of 19%. Since the percentage of subjects with positive exercise test is extremely low on account of the not high occurrence of ischemic heart disease in our country as well as of the limited sensitivity of this method, it is believed that the electrocardiographic exercise test is not a satisfactory tool for secondary prevention of coronary disease in the Italian population.

Adult↗
PubMed1975

Latent myocardial contractile impairment in patients with angina pectoris.

Intravenous injection of Angiotensin II gives rise to a rapid and transient increase of the afterload of the left ventricle (increased peripheral resistances). In this haemodynamic setting the functional behaviour of the left ventricle, through indirect parameters such as systolic time intervals, was compared in 14 patients with angina and in 15 normal control subjects. As regards blood pressure and heart rate a similar behaviour was registered in the two groups in basal conditions; directly after the intravenous injection of Angiotensin II changes suggesting impairment of left ventricular function failure have been obsered in patients with angina pectoris.

Adolescent↗
PubMed1975

[Evaluation of cardiac performace in 222 patients with pulmonary sarcoidosis (author's transl)].

Electrocardiogram at rest, blood pressure, systolic intervals (PEP/LVET), cardiothoracic ratio and circulation time were evaluated in 222 sarcoidotic subjects without cardiac symptoms and with no past or present history of cardiac disease. Very few, slight alterations were observed and were probably not the result of sarcoidotic myocardial involvement. Abnormalities distribution according to stage on the basis of chest-x-rays findings and the duration of sarcoidosis did not appear significantly different. Prospective study is being undertaken to determine which of the observed abnormalities may represent precursors or symptoms of sarcoidotic cardiac involvemenet.

Adolescent↗