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Biomedical subjects

M Radkov

Publications and source records attributed to M Radkov.

6 recordsLinked to original sources
PubMed1977

[Changes in the level of alpha1-antitrypsin in bronchial asthma].

The alfa1-antitrypsin level was followed up in patients with bronchial asthma with different forms and severity of the disease. The latter was found to be elevated in all patient groups with an average of 335,38 mg% as compared with the controls 290.83 mg%, p less than 0,01. The elevated antitrypsin is explained with the allergic process and the secondary bacterial inflammatory reactions, triggering the formation of antienzyme substances, in order to inactivate the enzymes, playing a certain role in the pathogenesis of the first two processes--allergy and bacterial inflammation. In patients, both treated and not with cortisone, antitrypsin is elevated with no manifestation of significant difference for both patient groups. The cortisone preparations very likely do not supress the antienzyme systems in organism. As regards the pathogenetic role of alfa1-antitrypsin deficiency in asthma, the latter is admitted to play an insignificant role only in single cases.

Adult↗
PubMed1976

[Serum immunoglobulin E level in bronchial asthma].

Serum immunoglobulin E level was determined in 50 patients with bronchial asthma, treated in the out-patients department and clinical conditions at the Faculty Hospital--Varna. The quantitative determination of immunoglobulin E was carried out by radial immunodiffusion according to Mancini with monospecific anti-IgE globulin serum from Behringswerke (GFR). A considerable elevation of immunoglobulin E in the patients' sera was found, at an average of 394 IU (control 124 IU). A discrepancy in serum immunoglobulin E level was established with the different clinical forms of asthma. The highest are the values with infectious-allergic astmha-424 IU. High are the values both in the treated and not-treated with corticosteroids, without an essential difference between the two patient groups. Some of the rest immunoglobulins showed also an elevationppIgG 2620 mg% and IgA 366 mg%.

Adrenal Cortex Hormones↗