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Biomedical subjects

M Radkowski

Publications and source records attributed to M Radkowski.

At least 55 records · Page 3Linked to original sources
PubMed1996

[Presence of autoantibodies in patients infected with HIV].

The presence of serum autoantibodies directed against single-stranded DNA (ssDNA), RNA, histones, nuclear antigen SS-A, mitochondria and cardiolipin were investigated in 30 HIV-negative drug addicts (from years 1986-87), 30 addicts actually infected with HIV and 31 AIDS patients presenting with clinical symptoms indicating autoimmune disorders. Positive results were found in 12 (40%) drug addicts from years 1986-87, 5 (16.7%) actually infected and 16 (51.6%) AIDS patients. Autoantibodies were more often detectable in patients with thrombocytopenia 8/12 (66.7%) than in remaining 8 out of 19 subjects (42.1%) who presented dermatitis, hepatitis, pancarditis, ulcerative colitis and polyneuropathy. The prevalence of autoantibodies in all investigated groups were significantly higher than in controls-1/20 (3.3%).

Acquired Immunodeficiency Syndrome↗
PubMed1996

[Coexpression of CD4 and CD8 antigens and the appearance of HLA-DR and CD25 receptors on lymphocytes as markers of immune activation in patients with HIV infection].

Results of quantitative determinations of peripheral blood lymphocytes presenting CD4 or simultaneously CD4 and CD8 antigens as well as HLA-DR and CD25 antigens in patients with different clinical stages of CD4+ and CD4+CD8+ cells were observed. The fall of CD4+CD8+ lymphocytes percentage was slight in the initial stages of infection but more sharp during the full-blown AIDS. The percentage of HLA-DR positive cells was higher in seropositive patients in comparison with controls and increased with the progression of HIV infection into AIDS. The CD25 expression was also higher in HIV-infected patients, however, it decreased in patients with late stages of AIDS. The observed disturbances could be caused by the direct destruction by replicating HIV or by severe abnormalities of immune system function.

Acquired Immunodeficiency Syndrome↗
PubMed1996

[The effect of discontinuing intravenous opiate injections and methadone treatment on the status of the immune system in narcotic abusers with HIV].

The effect of discontinuation of injecting drug use and administration of methadone was investigated in 43 HIV-infected drug abusers. In 20 (46.5%) out to them an improvement in the immune status as measured by CD4+ lymphocyte percentage and CD4/CD8 lymphocyte ratio was observed, while remaining 23 persons (53.5%) showed stable or decreasing values of both parameters. In the control group which consisted of 23 persons who continued injecting drug use, only 3 (13%) out of the showed increase in the CD4+ lymphocyte percentage and CD4/CD8 lymphocyte ratio. It seems that discontinuation of injecting drug use may improve the function of immune system in HIV-infected drug addicts and could be an important factor in the approach for treatment of these patients.

Adult↗
PubMed1996

[Antibody avidity in diagnosis of toxoplasmosis].

The sequential changes in avidity of antibodies to Toxoplasmosis gondii were investigated. The values of avidity were observed to be significantly lower in serum samples drawn in early stages of infection than 3-4 months later and increasing with time of duration of the infection. A correlation was found between antibody avidity and antibody level measured in international units (IU/l), whereas, no correlation was observed between avidity, IU/l and antibody titers.

Adolescent↗
PubMed1994

[Autoimmune phenomena in the course of chronic infections].

Probable mechanisms responsible for the development of autoimmune disorders in the course of acute and chronic infectious diseases are discussed in the paper. The most common infections ongoing with significant symptoms of immune reactions directed against self antigens are also presented.

Acute Disease↗
PubMed1994

[Occurrence of free receptor for interleukin 2 in serum and quantitative determinations of CD25+ in patients infected with HIV].

Serum soluble interleukin 2 receptor (sIL-2R) concentration and the percentage of lymphocytes presenting this receptor (CD25+) were investigated in 28 asymptomatic HIV carriers or patients with lymphadenopathy only and in 15 AIDS patients. The levels of sIL-2R were found to be higher in AIDS patients (mean 1060 U/ml) than in persons during the initial stages of infection (mean 750 U/ml) or controls (mean 470 U/ml). No significant differences in the quantity of CD25+ lymphocytes between these groups were observed, with the means of 1.0; 1.3 and 1.1, respectively. However, a decrease in percentage of these cells were found in patients with advanced HIV infection. Since sIL-2R is regarded as a marker of immune system activation its detection could be helpful in the assessment of the immune status impairment in HIV infected patients.

Acquired Immunodeficiency Syndrome↗
PubMed1993

Affinity of anti-GP41 antibody in patients infected with human immunodeficiency virus type 1.

Anti-gp41 antibody affinity was investigated prospectively in 25 patients with asymptomatic and symptomatic HIV-1 infection for a period of 9-42 months. Major differences in the processes of immune response maturation towards gp41 were observed among individual subjects, however, antibody affinity increased with time in all examined persons including patients with AIDS. Anti-gp41 affinity values were found to reflect both the duration and the clinical stage of HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1993

[Eleven year period of asymptomatic HIV infection in a patient after open heart surgery].

A case is described of a 62 years old patient in the initial stage of clinically overt HIV infection. The infection occurred probably 11 years earlier by means of blood transfusion during open heart surgery. The possible reasons for the long-term asymptomatic carriage of the virus and factors influencing the development of symptomatic HIV infection (AIDS) are discussed.

Acquired Immunodeficiency Syndrome↗
PubMed1993

[Evaluation of humoral immune response in patients with asymptomatic and symptomatic HIV infection. Analysis of titers of anti-Hbs, antibodies against cytomegalovirus, herpes simplex virus type I, rubella virus and toxoplasma gondii].

40 asymptomatic HIV carriers and 45 AIDS patients were tested for anti-HBs (Hepatitis B Virus surface antigen), anti-RV (Rubella virus), anti-Toxo (Toxoplasma gondii), anti-CMV (Cytomegalovirus) and anti-HSV-1 (Herpes simplex virus type 1) antibody titers and compared with 83 persons characterized by risk behaviours but seronegative for HIV. The prevalence of these antibodies was very high and similar in all three groups studied, however, patients with AIDS had generally lower antibody titers when compared with asymptomatic carriers. The only exception being anti-HSV-1 which was present in high titre even in gravely ill patients. It seems that subjects with clinically overt HIV infection develop a serious disturbance in the humoral immune response with depressed specific antibody synthesis.

Acquired Immunodeficiency Syndrome↗
PubMed1993

[Concomitant symptom syndrome of primary HIV infection].

A primary HIV infection presenting as an acute viral syndrome in 31-years-old male drug addict is described. Two weeks after the probable infection the patient presented with fever, sweats, anorexia, vomiting, diarrhoea, myalgia, arthralgia, headaches, macular eruption, generalized lymphadenopathy, paresthesia and thrombocytopenia. These symptoms lasted 7 weeks. The immune abnormalities included an increase of CD8+ lymphocyte percentage resulting in decrease od CD4/CD8 ratio. HIV antigenemia was found 4 weeks after the presumed exposure whereas anti-HIV became detectable 2 weeks later.

Acute Disease↗
PubMed1993

[Efficacy of hepatitis B vaccine after intramuscular or intradermal administration].

We compared the efficacy of intramuscular (im) and intradermal (id) administration of vaccine against HBV. Only one out of 25 im vaccinated subjects did not respond whereas all 25 id immunized persons developed anti-HBs above 10 IU/l. The mean serum level of anti-HBs in im and id vaccinated group was 2351 +/- 2358 IU/l and 1823 +/- 1502 IU/l, respectively (p = 0, 382; NS). It seems that the efficacy of both vaccine administration is very similar.

Adult↗
PubMed1992

Prevalence of markers of hepatotropic viruses among drug addicts in Warsaw, Poland.

We studied 100 unselected parenteral drug abusers for infection with hepatitis C, B, A and D virus (HCV, HBV, HAV and HDV). Seventy-six percent had serological evidence of HCV infection. 12% were positive for HBsAg and at least one marker of HBV infection was present in 69%. These results were significantly higher than in a matched control population. Compared to controls, the prevalence of anti-HAV (65%) was not significantly increased in drug addicts. Of the anti-HCV-positive drug addicts, 80.3% had at least one marker of HBV infection compared to 33.3% of anti-HCV-negative cases (p less than 0.001). No such correlation was found between the prevalence of HCV or HBV infection markers and the presence of anti-HAV. Antibodies against HDV were detected in 16 (16%) of the samples from drug addicts. No significant association was found between antibodies to HCV and gender, age and duration of drug abuse. The risk of HBV infection increased significantly with years of drug abuse but was not associated with age and sex. The presence of anti-HAV was related to age only. Sixteen (16%) of the subjects were definitely positive for anti-HIV-1, but at the time of the study they were asymptomatic. No significant association was found between the presence of anti-HIV and the prevalence of serological markers of HBV, HCV, HAV and HDV infection.

Adolescent↗
PubMed1992

Prevalence of markers of hepatitis viruses in out-patient alcoholics.

The prevalence of HCV, HBV and HAV markers was investigated in unselected patients attending an outpatient alcoholic clinic. Anti-HCV were detected in 35 (24%) of 144 patients studied, and at least one marker of HBV infection was present in 72 (50%). These results are significantly higher than in a matched control population. The presence of anti-HCV was related to previous blood transfusions and familial history of alcoholism. We conclude that alcoholics should be considered a high risk group for both HCV and HBV infection.

Adult↗