[Ophthalmologic implications in diabetes mellitus].
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Biomedical subjects
Publications and source records attributed to M Radnót.
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The lacrimal sac of a 79-year-old woman was examined in an electron microscope. Groups of oncocytes were found. The oncocytes are packed with mitochondria, the cristae of which have suffered damage.
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The vessel walls of six malignant choroidal melanomas were thin; only thin basal membranes and narrow endothelial linings could be observed with the electron microscope. The endothelium was even absent in some places. Tumor cells were released into the bloodstream through disruptions of the vessel walls in the epithelioid and spindle cell B type tumors.
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The photoreceptors and their synapses, the amacrine cells and a vein the nerve fibre layer of the human retina are shown on the basis of scanning electron microscopic investigations.
The nucleoli and intercellular spaces were studied in 10 cases of intraocular melanoblastoma. The sizes of the nucleoli vary from 1.5-2.0 micrometer. The various nucleolar types seen in other tumours were also observed in melanoblastoma. The width of the intercellular spaces varied from 230 to 1,300 A. In the gaps ruthenium red-positive material was shown. In some of the cases this material exhibits a peculiar regular structure, the fundamental units of which are built up of filaments of the same size as found in the intercellular material of other places, however, more or less electron-dense periods alternate.
In 3 cases of 29 retinoblastomas (roughly 10%) structures similar to processes of photoreceptors were found. In each of them so-called fleurette cells were seen. In one case, described in detail, many lamellar structures appeared corresponding to the outer segment of the photoreceptor.
Epibulbar tumour developed in the left eye of a 53-year-old woman. Light and electron microscopic study of the tumour revealed undifferentiated metastatic carcinoma. The patient underwent surgical intervention because of mammary carcinoma 5 years before the development of the epibulbar tumour.
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On the basis of SEM studies it has been shown that the cilia are arranged into groups of 10 to 40 in the individual epithelial cells of the lacrimal sac. The cilia have a length of 15 to 20 micron.
Scanning electron microscopic investigations were carried out in three cases of epitheloid melanoblastomas. Intercellular junctions were described which overbridged even broad intercellular spaces.