Biomedical subjects

M Raggio

Publications and source records attributed to M Raggio.

11 recordsLinked to original sources

PubMed2001

Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia.

BACKGROUND: Hairy-cell leukemia that is resistant to treatment with purine analogues, including cladribine, has a poor prognosis. We tested the safety and efficacy of an immunotoxin directed against a surface antigen that is strongly expressed by leukemic hairy cells. METHODS: RFB4(dsFv)-PE38 (BL22), a recombinant immunotoxin containing an anti-CD22 variable domain (Fv) fused to truncated pseudomonas exotoxin, was administered in a dose-escalation trial by intravenous infusion every other day for a total of three doses. RESULTS: Of 16 patients who were resistant to cladribine, 11 had a complete remission and 2 had a partial remission with BL22. The three patients who did not have a response received low doses of BL22 or had preexisting toxin-neutralizing antibodies. Of the 11 patients in complete remission, 2 had minimal residual disease in the bone marrow or blood. During a median follow-up of 16 months (range, 10 to 23), 3 of the 11 patients who had a complete response relapsed and were retreated; all of these patients had a second complete remission. In 2 of the 16 patients, a serious but completely reversible hemolytic-uremic syndrome developed during the second cycle of treatment with BL22. Common toxic effects included transient hypoalbuminemia and elevated aminotransferase levels. CONCLUSIONS: BL22 can induce complete remissions in patients with hairy-cell leukemia that is resistant to treatment with purine analogues.

Adult↗

PubMed2001

Adult testicular pure yolk sac tumor.

Here we describe the clinical, ultrasonographic and histological features of a rare pure adult yolk sac tumor detected in the right testis of a 44-year-old male. Due to the rarity of this neoplasm (less than 10 cases have been reported), there is no unanimous consensus for therapy following inguinal orchiectomy. We believe that nerve-sparing retroperitoneal lymph node dissection could be potentially curative and useful for future interpretations of this tumor's potential evolution.

Adult↗

PubMed2001

Scrotal extraperitoneal hernia of the ureter: case report and literature review.

Ureteral herniation is a rare, often misdiagnosed event and serious surgical complications are possible. Until 1992, 128 cases of ureteral herniation were reported and in 54 (42%) the inguino-scrotal region was involved. From an anatomical and pathogenic standpoint, two types of uretero-inguinal hernias can be identified: paraperitoneal (more frequent, acquired, always presenting a peritoneal hernia sac, frequently associated with other herniated abdominal structures) and extraperitoneal (very uncommon, congenital, never associated with a true peritoneal sac, always composed only of the ureter). We describe a new case of scrotal extraperitoneal ureteral hernia and review the current urological, surgical and radiological literature to analyze the main clinical characteristics of this pathology and its ideal treatment.

Aged↗

PubMed1988

Performance inventory for profound and severe loss (PIPSL).

This study was undertaken to develop a quantifiable and reliable self-rating inventory specifically for persons with profound and severe hearing losses. Fifty such subjects with such losses who wore hearing aids rated themselves on a scale of 0-6 (never to always) on 125 items that sampled their performance in a variety of communicative situations. Items were assigned to tentative categories that were then refined so as to achieve high internal consistency, reflected by high alpha coefficients, with a minimal number of items. Six final categories, or scales, containing a total of 58 items, emerged with alpha coefficients .86 or higher. The scales were labeled Understanding Speech With Visual Cues, Intensity, Response to Auditory Failure, Environmental Sounds, Understanding Speech With No Visual Cues, and Personal. Another 16 items that failed to fit into any scale, and did not form a scale of their own, were also included in the final inventory because they related to individual rehabilitative concerns and activities in ways not represented among the items of the six scales.

Adult↗

PubMed1987

The UCSF tracking procedure for evaluation and training of speech reception by hearing-impaired adults.

A tracking procedure that emphasizes practical coping strategies for hearing-impaired patients, along with practice in responding to other cues in the perception of connected speech, is described in detail in the course of its use with one subject. The subject's tracking scores before and after training illustrate the potential value of the procedure both as an evaluative measure and as a training tool. The organization of the materials and the design of the training protocol allow for a wide range of practice activities in tracking, including the use of nonverbatim as well as verbatim responses.

Aged↗

PubMed1986

Solving audiometric masking dilemmas with an insert masker.

For some bilateral hearing losses, standard audiometric techniques cannot provide sufficient data for correct otologic diagnosis. These hearing losses are termed "masking dilemmas" because sound attenuation across the head is inadequate to prevent unwanted masking of the test cochlea. In most cases, the masking dilemma can be eliminated by presenting masking through an insert phone in the ear canal, rather than through a standard earphone and cushion. Insert earphones are not standard on most audiometers, but the minimal necessary equipment and alterations are inexpensive, readily available, and require little time to implement. Test time is not increased significantly. Some masking dilemmas will not be solved by the insert masker, but, when properly constructed and used, an insert masker will provide an accurate measurement of cochlear reserve not otherwise obtainable for most cases.

Acoustic Impedance Tests↗

PubMed1983