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Biomedical subjects

M Rajić

Publications and source records attributed to M Rajić.

15 recordsLinked to original sources
PubMed2003

Urinary PC-1 activity in patients with type 1 diabetes mellitus.

BACKGROUND: Insulin resistance characterizes type 1 diabetes mellitus with nephropathy. The molecular mechanisms of insulin resistance are not completely understood. Recently some advances have been made in identification of transmembrane glycoprotein PC-1 as a potential factor of insulin resistance. METHODS: We measured urinary excretion of PC-1 (alkaline phosphodiesterase I), a potential factor of insulin resistance, and N-acetyl-beta-D-glucosaminidase (NAGA) in 62 type 1 diabetic patients with different damage to the kidney. RESULTS: In newly detected type 1 diabetes patients, before insulin therapy, urine PC-1 excretion was significantly increased (P<0.05) over the control level. However, in patients after 12.4 years of therapy, urinary PC-1 was significantly decreased (P<0.05). Decreased urine PC-1 activity (P<0.05) was found also in type 1 diabetes patients with microalbuminuria and manifest nephropathy, including those with renal failure. Urinary NAGA excretion was found to be significantly increased (P=0.001) in all but the group of type 1 diabetes patients without nephropathy. CONCLUSION: This study of urinary PC-1 in patients with type 1 diabetes shows increased excretion in newly detected patients with poor glycaemic control, but decreased excretion in patients with micro-/macroalbuminuria as well as in those without apparent kidney damage. In patients with primary glomerulonephritis, urinary excretion of PC-1 was significantly decreased and that of NAGA significantly increased compared with the excretion in healthy controls.

Acetylglucosaminidase↗
PubMed2000

Radionuclide voiding pattern in children with unstable bladder.

BACKGROUND: The purpose of this study was to investigate bladder function parameters by means of quantitative radionuclide cystography (QRC) in anxious, irritable children with unstable bladder. METHODS: Quantitative radionuclide cystography was performed in 18 children aged between 8 and 12 years, without evidence of neurologic and nephrologic disorders. Findings were compared with those obtained in 10 healthy children aged between 7 and 10 years. The dynamics of the bladder emptying were studied after intravenous injection of 37 MBq/10 kg b.w. 99mTc-diethylenetriaminepentaacetic acid (DTPA) in the posterior views. Images of 90 frames every 2 sec. were stored in the 64 x 64 computer matrix during voiding. The patients voided into a container and the volumes were measured. RESULTS: The parameters evaluated were: functional bladder capacity (ml)--FBC, expected bladder capacity (ml)--EBC, percentage of EBC (%), voided urine volume (ml)--VV, residual urine (ml)--RU, voiding time (sec)--VT, average flow rate (ml/sec)--AFR and peak flow rate (ml/sec)--PFR. There was a statistically significant difference between controls and children with unstable bladder in the following parameters: FBC 288 +/- 33 vs. 244 +/- 27 ml (p < 0.001), % of EBC 99 +/- 6 vs. 82 +/- 6% (p < 0.0001), VV 265 +/- 37 vs. 202 +/- 35 ml (p < 0.0001), RU 22 +/- 11 vs. 48 +/- 19 ml (p < 0.007), AFR 13 +/- 5 ml/sec vs. 9 +/- 4 ml/sec. (p < 0.01) and PFR 19 +/- 2 vs. 13 +/- 3 ml/s (p < 0.0001), respectively. The VT obtained from the control group of 23 +/- 9 s did not differ significantly from the value of children with unstable bladder of 28 +/- 14 s. CONCLUSION: The results show that quantitative radionuclide cystography is a simple, noninvasive method, which allows a good separation of patients with unstable bladder from the children with normal voiding pattern.

Journal Article↗
PubMed1998

Elevated tumour markers in patients with Balkan endemic nephropathy.

Balkan nephropathy (BEN) is commonly associated with urothelial cancer. Urothelial cancer is manifested in the advanced stage of disease. The aim of this study was to facilitate early detection of urothelial cancer in BEN patients and their family members living in an endemic region by using tumour markers, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA), and a putative marker, ferritin. Fifteen BEN patients with normal renal function, 17 with renal failure (BEN-RF), 13 healthy members of their families (HFM), 14 patients with glomerulonephritis (GN) and 12 healthy controls (C) were studied. Serum CEA levels in BEN patients were within normal limits, however, in BEN-RF patients they were significantly increased over HFM (p<0.05). Serum TPA levels in BEN and BEN-RF patients were significantly higher than in the C and HFM groups (p<0.05). Urinary CEA was not significantly different between the groups studied. Urinary TPA levels in HFM (median 125 U/l, BEN (236 U/l) and BEN-RF (275 U/l) were significantly increased over C (30 U/l), however, TPA levels were increased also in GN patients (437 U/l). None of the BEN patients studied developed urothelial cancer during the ten years' follow-up. Markedly elevated urinary TPA-like levels in all patients studied (HFM, BEN, BEN-RF, GN) suggest that urinary TPA may not be a reliable tumour marker. However, the clinical relevance of high TPA levels in BEN patients should be evaluated.

Balkan Nephropathy↗
PubMed1996

[Treatment of renal insufficiency in patients with multiple myeloma].

Multiple myeloma is the most frequent dysproteinaemica causing renal damage. Renal damage can be manifested as acute or chronic renal failure, Tubular disfunction, urinary tract infection, or as proteinuria. The aim of this study is to present our experience in the treatment of renal failure developed during multiple myeloma. Over a ten year period we treated 16 uraemic patients with multiple myeloma and renal failure. Most patients (75% or 12 of them) came to the nephrologic department because of acute renal failure provoked by multiple myeloma. Dialysis was applied to 9 patients. The average survival rate of these patients ranged from 6.2 +/- 9.2 months, while three patients lived for 23-24 months. The combination of chemotherapy and dialysis did not produce recovery of renal function in any case of acute renal failure. All deaths were related to the evolution of multiple myeloma and none to a complication of dialysis. In conclusion, dialysis treatment should be used even in cases of uraemia, if myeloma is not in the terminal phase.

Adult↗
PubMed1977

[Anti-Bg(HL-A) antibodies].

The presence of specific anti-Bg hemaggluttinine in the sera of four patients, is shown. All our patients with anti-Bg antibodies had the antigen B27 on the HLA complex present. Anti-Bg antibodies were prooved by the Coombs technique.

ABO Blood-Group System↗
PubMedDate not supplied

[Incidence of lymphoma cells in the bone marrow and peripheral blood in patients with non-Hodgkin's type lymphoma].

The appearance of lymphomatous cells in the bone marrow and peripheral blood in 120 patients with Non-Hodgkin's lymphomas (NHLs), was investigated. The presence of lymphomatous cells in the bone marrow was found in 56.6% ob patients and in the peripheral blood in 23.3% of individuals. Lymphomatous site in the bone marrow was proportionally frequent in the group of patients with the high grade aggressive NHLs in comparison to the low grade group. The finding of the peripheral blood occupation was reversible However no significant statistical difference was found. The results also suggest that lymphomatous invasion of the bone marrow does not obligatory predict the invasion of the peripheral blood. Reverse correlation between the frequent bone marrow and peripheral blood occupation by lymphomatous cells and the mean survival time which was significantly shorter in the patients who exhibited the invasion of any kind, was also found. This means that lymphomatous invasion of the bone marrow and peripheral blood might be a potentially useful parameter of the clinical aggressiveness and the course of the disease.

Bone Marrow↗
PubMedDate not supplied

[Fixation of tubules with radioactive technetium dimercaptosuccinate in parenchymal diseases of the kidney].

In order to evaluate tubular function 99mTc-DMS dynamic kidney scintigraphy and 99mTc-DMS uptake determinations were performed in 55 patients with endemic nephropathy, diabetic nephropathy and glomerulo nephritis. From 64-656th segment of computerized radiorenograms 99mTc-DMS uptake and curve slope were assessed and compared with the corresponding parameters of 20 healthy subjects. Both parameters were decreased in patients of all three groups. Tubular uptake of 99mTc-DMS measured during 60 sec. 4 hours after 99mTc-DMS administration, was decreased in endemic nephropathy and diabetic nephropathy, but without a significant difference in glomerulonephritic patients. The study of the relationship between 4 hour 99mTc-DMS tubular fixation and glomerular filtration rate, estimated by 99mTc-DTPA clearance, showed a positive correlation only in patients with diabetic nephropathy. Patients with renal failure from all three groups had more seriously impaired tubular handling of 99mTc-DMS, that correlated with reduction of the glomerular filtration rate. The present data showed more severe impairment of tubular function in patients with endemic nephropathy and diabetic nephropathy than in glomerulonephritic patients. The method was suitable for estimation of the tubular function.

Balkan Nephropathy↗