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Biomedical subjects

M Rantala

Publications and source records attributed to M Rantala.

35 records · Page 2Linked to original sources
PubMed1997

Tubal patency and fertility outcome after expectant management of ectopic pregnancy.

OBJECTIVE: To study tubal patency and fertility outcome of patients with expectantly managed ectopic pregnancy (EP). DESIGN: A prospective study. SETTING: Department of Obstetrics and Gynecology, Turku University Central Hospital, Turku, Finland. PATIENT(S): Thirty patients who wanted to become pregnant again were treated successfully by expectant management of EP. INTERVENTION(S): Patients were examined with posttreatment hysterosalpingography, and they filled out a questionnaire about their subsequent pregnancies. MAIN OUTCOME MEASURE(S): Free passage through open lumen showing tubal patency; number of full-term pregnancies and EPs revealing relative rate of subsequent fertility. RESULT(S): A free passage through the diseased tube was seen in 93% of the cases (28 of 30). Two of the 24 patients (8.4%) who wanted to become pregnant had an obstruction in the diseased tube. One (4.2%) of them had a normal opposite tube and later had a normal pregnancy. The other (4.2%) had an obstruction in both tubes and subsequently had a repeat EP. One of the 6 patients had an EP (this patient did not want to become pregnant and did not use contraception). However, her posttreatment hysterosalpingography was normal. In total, the subsequent pregnancy rate was 88% (21 of 24), and the rate of repeat EP was 4.2% (1 of 24). CONCLUSION(S): Patients who are treated with expectant management have a good long-term fertility outcome. Spontaneous regression of EP does not lead to increased harm or damage to the tube, i.e., the risk for repeat EP is low.

Adult↗
PubMed1997

Apolipoprotein E phenotype and diet-induced alteration in blood pressure.

The purpose of the study was to answer the following two questions. First, are the diet-induced changes in the plasma cholesterol concentration associated with a change in blood pressure? Second, is the possible diet-induced change in blood pressure related to the apolipoprotein E (apo E) phenotype? Two hundred employees of our hospital volunteered and among those, 23 subjects with the apo E3 (E3,3) and 21 with the apo E4 phenotype (E4,3 or 4,4) were selected. The apo E groups were age- and sex-matched. Study subjects were healthy, had normal body weights, and their mean (+/-SD) age was 37.9 +/- 7.7 y. The total energy derived from dietary fat was 37%, 26%, and 38% during the baseline, low-fat, and high-fat diet periods, respectively. The two intervention diets were consumed by the study subjects for 4 wk at a time. During the trial blood pressure was measured once a week with an automatic device under standardized conditions. Systolic, diastolic, and mean arterial pressures were significantly reduced during the low-fat diet period compared with baseline, but not compared with the high-fat diet period among the apo E4 subjects only (-6%, -4.5%, and -6%, respectively). The high-fat diet was associated with elevation of blood pressure among 70% of study subjects. A slight but significant positive correlation was noted between the plasma total cholesterol concentration and blood pressure, more so among the apo E4 subjects. Furthermore, age was correlated with blood pressure response in apo E4 subjects. In conclusion, both the systolic and diastolic blood pressures were significantly altered during the different diet periods. The dietary response of blood pressure seemed to differ between subjects with the apo E4 and those with the apo E3 phenotype.

Adult↗
PubMed1997

Laparoscopic instillation of hyperosmolar glucose vs. expectant management of tubal pregnancies with serum hCG < or = 2500 mIU/mL.

OBJECTIVE: To compare expectant management with local instillation of 50% glucose solution for tubal pregnancies with a serum hCG level < or = 2500 mIU/mL. DESIGN: Prospective, non-randomized, comparative clinical study. SETTING: Two university departments. PATIENTS: One hundred and twenty-eight patients with laparoscopically-confirmed tubal pregnancy and serum hCG < or = 2500 mIU/mL. INTERVENTIONS: Eighty patients in Graz were treated with laparoscopic instillation of 50% glucose solution and 48 patients in Turku were followed expectantly. MAIN OUTCOME MEASURES: Resolution of hCG excretion, need for further interventions. RESULTS: Seventy-four of the 80 patients (92%) in the glucose group (32 of 33 with an initial hCG < or = 250 mIU/mL and 42 of 47 with hCG 251-2500 mIU/mL) and 36 of 48 (75%) patients in the expectant group (19 of 23 with an initial hCG < or = 250 mIU/mL and 17 of 25 with hCG 251-2500 mIU/mL) had resolution of the pregnancy with no further intervention (p=0.008, chi-square test, odds ratio 0.24). CONCLUSIONS: Glucose instillation is superior to expectant management for patients with early tubal pregnancy.

Adult↗
PubMed1996

Ethanol-induced redistribution of cholesteryl ester transfer protein (CETP) between lipoproteins.

Since alcohol drinking reduces the concentration and activity of plasma cholesteryl ester transfer protein (CETP), we investigated the effects of alcohol on its synthesis and secretion by perfusing rabbit livers for 4 hours in the absence or presence of ethanol. The quantity of CETP mRNA in the perfused livers did not differ between the control and ethanol (25 mmol/L or 50 mmol/L) perfusions. CETP activity was determined by incubating [3H]cholesteryl ester-labeled human LDL and unlabeled human HDL with the perfusion medium after removing the endogenous VLDL (secreted by the perfused liver) by ultracentrifugation. CETP activity in the perfusion medium increased at a linear rate that was not affected by ethanol. When the VLDL was removed by precipitation with polyethylene glycol or a heparin-Sepharose column instead of ultracentrifugation, practically no CETP activity was detected in the ethanol perfusions, whereas these procedures did not affect CETP activity in the control perfusions. Inhibition of ethanol oxidation by 4-methylpyrazole resulted in CETP activity similar to that of the controls. We conclude that ethanol does not affect the synthesis or secretion of CETP, but its oxidation may alter the distribution of CETP in lipoproteins. CETP seems to be present in VLDL as well as in HDL, and since VLDL is more rapidly catabolized with HDL, this may explain the low plasma CETP concentration associated with alcohol consumption.

Animals↗
PubMed1996

The effect of sour milk as a postmilking teat dip for mastitis prevention in a dairy herd.

In a preliminary in vitro study, the growth of Staphylococcus aureus was totally inhibited during incubation for 24 h at 35 degrees C-37 degrees C in a solution of cooked commercial milk with 1% of uncooked commercial sour milk ("A piimä"). In a subsequent clinical trial, "A piimä" sour milk with 5% glycerol was used as a postmilking teat dip from February to June. Quarterly milk samples were drawn once a month aseptically from 133 cows. Percentages of pathogen positive samples and somatic cell count (SCC) from teats dipped with the sour milk were compared with those dipped with a commercial iodine teat dip and those of undipped controls. During March-June there were fewer isolations of S. aureus (2.09%) and coagulase-negative staphylococci (2.52%) in the sour-milk group than in the control group (3.09% and 4.07%, respectively). In iodine group, there were fewer isolations of S. aureus (0.83%) but more isolations of coagulase-negative staphylococci (5.26%) than in the control group. During the study period, the percentages of bacterial isolates did not differ statistically significantly between treatments, p = 0.291. The percentage of quarters with a SCC over 125,000 at the end of the study was one third lower in the sour-milk group than in the control group (16.67% and 26.23% respectively) but the difference was not statistically significant (p = 0.074). The results indicate that a sour-milk teat-dip preparation can inhibit new intra mammary infections (IMI).

Animals↗
PubMed1991

Magnitude of dietary effects on plasma cholesterol concentration: role of sex and apolipoprotein E phenotype.

The effects of fat-controlled, low-cholesterol and high-fat, high-cholesterol diets pursued for 4 weeks on plasma lipids and lipoproteins were studied in 44 healthy middle-aged subjects (22 women and 22 men). All the calories were supplied from the hospital kitchen. When the subjects were switched from the fat-controlled, low-cholesterol diet to the high-fat, high-cholesterol diet the average increase in total cholesterol was 1.2 mmol/l (28%), ranging from 0.2 to 2.7 mmol/l (4-56%). At the same time the average increase in LDL cholesterol was 1.0 mmol/l (39%), ranging from 0.1 to 2.4 mmol/l (3-90%). Interestingly, the men responded to the dietary changes more sensitively than the women. The increase in total cholesterol from the low-fat to the high-fat diet was 31% for the men and 25% for the women (P less than 0.05), the corresponding increases in LDL cholesterol being 42% and 37%, respectively (P less than 0.05). A marked increase in HDL cholesterol was observed when the subjects were switched from the low-fat to the high-fat diet, the increase being 30% for the men and 20% for the women. The absolute and percentage lipid changes on the two diets were equal in the subjects with the common apolipoprotein E phenotype 3/3 and in those homozygous and heterozygous for the epsilon 4 allele (E4/4 and E4/3).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

Clinical and CT correlates in the diagnosis of intracranial tumours.

The correlation between clinical and CT findings in cerebral tumours was prospectively studied in 1191 consecutive referrals for cerebral CT. CT revealed a mass lesion in 51 cases (4.3%): 32 neoplasms, five haematomas and one abscess. The diagnostic specificity of CT for neoplasmic tumours was 86% (32 of 37). The clinical suspicion of a cerebral neoplasm was correct in 25 cases (78%) and the clinical localisatory hypothesis was correct in 20 cases (63%) of the neoplasms. A cerebral tumour was found in 5% (11 out of 226) of patients investigated for their first seizure and in 1% (two of 207) investigated for headache without clinical signs.

Adolescent↗
PubMed1987

Childlessness in Helsinki.

Childlessness in Finland is analyzed using data collected by questionnaire from 4,730 women living in Helsinki who participated in a cervical cancer screening program in 1981-1982. "About half (48%) of the women aged 30 had no children. In the age group of 35 years, 28% were nulliparous as were 24% of the women aged 40."

Age Factors↗
PubMed1974

Hazards involved in the use of furazolidone for the prevention of salmonellosis in broiler chickens.

The purpose of this work was to study the effects of interrupted, continuous and post-salmonella inoculation treatment with furazolidone in the feed on the colonization of Salmonella infantis in the intestines of chickens, as well as the influence of furazolidone in vitro on the effect of a mixed culture used for the prevention of salmonellosis in chickens.It was shown that chickens given interrupted treatment with 0.01% furazolidone had significantly more salmonellas in the caeca than either chickens fed continuously with this drug or chickens without any treatment. The use of 0.01% furazolidone after inoculation with Salmonella infantis had no effect on Salmonella infantis in the caeca of chickens.The mixed bacterial culture from the normal intestinal flora lost its preventive effect on salmonellosis when cultured with 0.01% furazolidone.

Administration, Oral↗