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Biomedical subjects

M Rasoulpour

Publications and source records attributed to M Rasoulpour.

8 recordsLinked to original sources

Systemic hypertension.

Hypertension in neonates is no longer a rare entity due to improved methods of surveillance, increased vigilance on the part of clinicians, and as a complication of the technologies employed in neonatal intensive care units. Although good broad-based normative blood pressure data in preterm and term neonates is not available, the existing literature allows us some guidelines for defining hypertension. The multiple etiologies and clinical presentations are discussed, as well as a practical approach to evaluation. Pharmacologic management is presented, including some of the newer drugs. With aggressive management, the prognosis for resolution of hypertension in almost all instances is excellent; however, it remains to be seen what, if any, long-term effects will occur.

Antihypertensive Agents

Epidemiology of a cluster of Henoch-Schönlein purpura.

We investigated a case cluster of Henoch-Schönlein purpura that occurred in Connecticut during the fall and winter of 1987-1988. In Hartford County, where the case finding was most complete, 16 children were identified with disease onset during the 7-month cluster period (incidence, 1.7 cases per 10,000 children per year) compared with only 3 children with disease onset during the preceding 7 months. The incidence in Hartford County was higher among urban (4.8/10,000) and Hispanic (8.6/10,000) children and children in lower socioeconomic groups (6.9/10,000) than among suburban children or children in higher socioeconomic or different racial groups (0.9 to 1.1 per 10,000). We performed a case-control study involving 14 of the 16 case children from Hartford County, 10 case children from nearby areas, and 47 control children matched to the case children by age and race. Case children were more likely than control children to have had a sore throat during the month before the onset of Henoch-Schönlein purpura (52% vs 22%; odds ratio, 3.8; 95% confidence interval, 1.1 to 13). This difference and other smaller differences between case and control children suggest that the cluster may have been caused by person-to-person spread of an infectious agent of the respiratory tract to susceptible hosts. To our knowledge this is the first report of a cluster of Henoch-Schönlein purpura, and it provides clues for a better understanding of the etiology and epidemiology of the disease.

Antibodies, Bacterial

Vascular anatomy of the human uterus and pregnancy wastage.

In uteri removed at hysterectomy the uterine arteries were injected with radioopaque media and the vascular configuration was correlated with reproductive histories. Patients whose uteri had two ascending uterine arteries on each side had significantly more abortions and smaller newborn infants than patients with a single ascending branch of the uterine artery.

Abortion, Spontaneous

Cerebral vascular accident during the recovery phase of hemolytic uremic syndrome.

The hemolytic uremic syndrome (HUS) of children is characterized by microangiopathic hemolytic anemia and acute renal failure. Although a wide spectrum of neurologic symptoms are commonly observed in patients with HUS, the pathogenesis of the central nervous system (CNS) impairment of HUS is often unclear. Microthrombi of cerebral vessels similar to those demonstrated in the kidneys have been reported. The neurologic manifestations generally occur during the early and active phase of the disease. We report a 4 year old boy with HUS who suddenly developed a dense hemiplegia subsequent to hematological and a marked nephrological recovery. The child's cranial axial tomography scan demonstrated a large area of infarction in the region of the right basal ganglia. Follow up examination eight weeks after insult revealed a distinct neurologic recovery with mild loss of fine motor function of the left hand and weakness of the left leg.

Cerebral Infarction