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Biomedical subjects

M Redd

Publications and source records attributed to M Redd.

4 recordsLinked to original sources
PubMed2001

The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p).

Xpo1p (Crm1p) is the nuclear export receptor for proteins containing a leucine-rich nuclear export signal (NES). Xpo1p, the NES-containing protein, and GTP-bound Ran form a complex in the nucleus that translocates across the nuclear pore. We have identified Yrb1p as the major Xpo1p-binding protein in Saccharomyces cerevisiae extracts in the presence of GTP-bound Gsp1p (yeast Ran). Yrb1p is cytoplasmic at steady-state but shuttles continuously between the cytoplasm and the nucleus. Nuclear import of Yrb1p is mediated by two separate nuclear targeting signals. Export from the nucleus requires Xpo1p, but Yrb1p does not contain a leucine-rich NES. Instead, the interaction of Yrb1p with Xpo1p is mediated by Gsp1p-GTP. This novel type of export complex requires the acidic C-terminus of Gsp1p, which is dispensable for the binding to importin beta-like transport receptors. A similar complex with Xpo1p and Gsp1p-GTP can be formed by Yrb2p, a relative of Yrb1p predominantly located in the nucleus. Yrb1p also functions as a disassembly factor for NES/Xpo1p/Gsp1p-GTP complexes by displacing the NES protein from Xpo1p/Gsp1p. This Yrb1p/Xpo1p/Gsp1p complex is then completely dissociated after GTP hydrolysis catalyzed by the cytoplasmic GTPase activating protein Rna1p.

Active Transport, Cell Nucleus↗
PubMed1999

Modular transitional implants to support the interim maxillary overdenture.

It has been reported that for implants to become osseointegrated, they must heal in the absence of functional loads for 4 to 6 months. To address the need for undisturbed healing and patient demand for uninterrupted immediate function and esthetics, the Modular Transitional Implant and Prosthetic System has been developed. This case report describes the use of transitional implants to support a removable maxillary overdenture, including methodology and the advantages and disadvantages of the system. The histomorphometric analysis of one of these transitional implants and its surrounding osseous tissue showed a 45% bone-to-implant interface after 6 months of functional loading. The transitional implant system is a sound and economical method of immediate patient restoration that allows for the protected healing of submerged implants.

Bite Force↗
PubMed1992

Social facilitation of eating: effects of social instruction on food intake.

To investigate whether social influences cause increases in eating behavior, thirty undergraduate psychology students completed a diet diary for three 5-day periods. Subjects were instructed to either eat alone or eat with other people, actively eating with them for two of these periods. For the third period, subjects were instructed to eat as they normally would (with or without other people present). When instructed to eat with others present, subjects overall consumed more food, water, sodium, and alcohol than when they were instructed to eat alone. In the normal condition, food intake was 60% higher when the subjects ate with others present than when they ate alone. These results suggest that social facilitation has a causal influence on eating which increases food intake.

Adolescent↗