Clarification needed for raloxifene use.
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Biomedical subjects
Publications and source records attributed to M Reinders.
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OBJECTIVE: To analyse the outcome of preoperative biliary drainage in patients being operated on for a tumour in the pancreatic head. DESIGN: Retrospective study. SETTING: University hospital, The Netherlands. SUBJECTS: Consecutive series of 241 patients. MAIN OUTCOME MEASURES: Decline in bilirubin concentrations and bacterial contamination of bile as a result of preoperative drainage. Incidence of postoperative complications in patients who underwent preoperative drainage and those who did not. RESULTS: 184/241 patients underwent preoperative biliary drainage. Endoscopic drainage was the most effective, shown by a median reduction in bilirubin concentrations of 82%, 74%, and 50% after endoscopic drainage (n = 149), papillotomy (n = 25) and external drainage (n = 10), respectively. Bacterial contamination of bile was significantly more common when an endoprosthesis was used, but did not result in a higher rate of infective complications. 163 Whipple's resections, 33 total pancreatectomies, and 45 biliary-enteric bypasses were performed. 137/241 (57%) patients had postoperative complications. There was no significant difference in the incidence of postoperative complications between patients who had preoperative biliary drainage and those who did not (p = 0.4).
This study examined patient acceptance of two different advance directives. Outpatients completed the two directives and a 12-item acceptability questionnaire for each, and then stated their directive preferences. Of 128 patients enrolled, 97 (76%) responded. Overall, 47% of the respondents were satisfied with the Let Me Decide directive and 53% with the Medical Directive (NS). Thirty-nine percent preferred the Let Me Decide directive, 37% preferred the Medical Directive, and 25% had no preference or were uncertain which they preferred. Although there was no difference in patient acceptance between the directives, 76% of the patients preferred one or the other. Therefore, different people like different directives, and a variety of directives should be available for patients to review before they complete one.
Contractures of the hand are rather uncommon conversion phenomena. As yet, very little is known about treatment. After a brief overview of the literature on the various treatment strategies, we describe the treatment of four patients. There are indications that a complaint-centered approach, which attempts to influence the symptom directly, produces positive results. Hypnotherapeutic techniques were used in the four patients described here. Treatment resulted in improvement in three of the four.
A number of independent cDNA clones of the Piry virus N gene message were identified and sequenced. From the resulting sequences and previously published data, we derived the sequence of the mRNA for this protein. Sequence similarities of the translated region of Piry virus with that of other viruses suggest that Piry virus is as distantly related to Chandipura virus as it is to the vesicular stomatitis viruses of Indiana and New Jersey serotypes. Based on the relative conservation of the amino acid sequence of the nucleocapsid protein of these vesiculoviruses, the N protein can be subdivided into at least three regions, possibly indicative of functional domains.
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