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Biomedical subjects

M Reiner

Publications and source records attributed to M Reiner.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Retroperitoneal fibrosis and portal hypertension].

A patient is described in whom retroperitoneal fibrosis manifested itself by bleeding from ruptured varices and pain in the left flank and lumbar region. The clinical diagnosis was confirmed by axial computerized tomography and MRI, while the histology from a mesenteric biopsy taken during splenectomy was considered insufficiently consistent with the diagnosis of retroperitoneal fibrosis. Treatment with prednisone resulted in relief of lumbar and flank pain a well as in prevention of further digestive tract hemorrhage. A review of the literature since 1966 shows 16 articles describing the association of retroperitoneal fibrosis and portal hypertension manifesting itself by hemorrhage from bleeding varices.

Aged↗
PubMed1991

Salmonella typhimurium appendicitis.

A child with signs and symptoms of acute gastroenteritis developed localization of her pain to the right lower quadrant. A clinical diagnosis of appendicitis was made and an inflamed appendix was found at surgery. The postoperative period was marked by high spiking fevers and profuse nonbloody diarrhea. Cultures of the appendix and the stool revealed Salmonella typhimurium. Nontyphoidal Salmonella organisms are a rare cause of acute suppurative appendicitis. Intraoperative cultures of the appendix and peritoneal fluid as well as postoperative cultures of the diarrheal fluid were crucial in elucidating the cause of this patient's unusual course.

Adolescent↗
PubMed1988

The neuropathic joint in diabetes mellitus.

This article discusses the development and treatment of Charcot's joints in patients with diabetic peripheral neuropathy. Historical and clinical reviews are presented, as are case illustrations. This article provides the practitioner with a comprehensive review of diagnosis and treatment of this clinical entity.

Adult↗
PubMed1987

[Study of gallbladder emptying using 99m Tc-HIDA in acalculous cholecystopathy].

So-called acalculous gallbladder disease is an ill-defined entity, mainly seen in young women, which could be due to a motility disorder of the biliary tract. Seven young women with relapsing pain in the right upper quadrant of the abdomen or in the epigastrium, with cholesterol crystals in the bile and with normal sonographic and radiologic findings as well as normal gastroscopy, were investigated by hepato-biliary scintigraphy with 99mTc-HIDA. This first group was compared with a second group of 6 young women suffering from irritable colon, and with a third group of 6 asymptomatic control subjects. The half emptying-time of the gallbladder after cholecystokinin injection was 104.36 +/- 43.93 minutes in the first group, 17.92 +/- 23.57 minutes in the second and 20.42 +/- 23.67 minutes in the third group (p less than 0.005). After 6 weeks of ursodeoxycholic acid treatment, regression of pain and a significant reduction in the half emptying-time from 104.36 +/- 43.93 to 74.35 +/- 52.79 minutes (p less than 0.01) was observed in the first group. These results, which need to be confirmed by further studies, show that in acalculous gallbladder disease there is a delay in gallbladder emptying which could explain the formation of cholesterol crystals by bile stasis as described by various authors.

Adult↗
PubMed1985

Antipyretic activity of nimesulide suppositories: double blind versus diclofenac and placebo.

The acute antipyretic activity of nimesulide 200 mg suppositories was tested in a double-blind trial using diclofenac 100 mg suppositories as active reference drug and placebo as blank reference. Eighty-one patients (52 males and 29 females) aged between 18 and 90 years (mean 65 +/- 16.4), with fever of various etiology entered the study. Body temperature, heart rate and blood pressure were recorded before the drug administration and than after 30, 60, 90, 120, 240 and 360 minutes. Nimesulide proved to be as effective as diclofenac in normalizing body temperature and fever related objective signs (heart rate and arterial pressure), significantly shortening fever duration with respect to placebo. The tolerability of both treatments was in general good: 3 cases of nimesulide group (10%) and 4 cases of diclofenac group (17%) complained of slight and transitory side effects. No side effects were complained in the placebo group.

Adolescent↗
PubMed1984

Nimesulide in the treatment of fever: a double-blind, crossover clinical trial.

A double-blind, crossover clinical trial was carried out in subjects with fever, to assess the activity of three antipyretic drugs. Eighteen in-patients with body temperature (axillary) above 38 degrees C were given a single dose of nimesulide 100 mg, acetylsalicylic acid 500 mg, and dipyrone 500 mg, orally according to an incomplete balanced block design. Significant improvement was recorded with nimesulide and dipyrone, which gave similar results. Acetylsalicylic acid normalized body temperature in a few patients. Safety was very satisfactory. No local or systemic side-effects were noted.

Adult↗
PubMed1983

Nimesulide and antibiotics in the treatment of acute infections of the respiratory tract.

A double-blind, placebo-controlled trial was carried out in 45 hospitalized adult patients requiring antibiotic therapy for acute or chronic respiratory tract infection to compare the effectiveness of antibiotic treatment alone or with the concomitant use of nimesulide, a new non-steroidal anti-inflammatory agent. Patients were allocated at random to receive antibiotic treatment plus either nimesulide (100 mg twice daily) or placebo over a period of 15 to 23 days. The results showed that the patients in the nimesulide group had significantly greater and more rapid improvement in signs and symptoms such as chest pain, cough, oropharyngeal hyperaemia, asthenia, as well as osteoarticular pain in those arthrosis-affected patients, than those treated with antibiotic plus placebo. Treatment was well-tolerated and very few, mild side-effects were reported.

Adult↗
PubMed1982

Nimesulide in the short-term treatment of osteoarthrosis: a pilot study for assessing the minimal effective dose.

Eleven patients suffering from osteoarthritis of the cervical spine were admitted to a pilot study aimed at establishing the effective dose and the tolerability of Nimesulide. The patients received a basic treatment of Nimesulide 100 mg/day, increasable up to 300 mg/day, in conformity with the patient's need. The treatment over a period of 15 days showed that Nimesulide 200 mg/day has good anti-inflammatory and analgesic properties. Several critical parameters were significantly improved. The incidence of usually mild side-effects was very low.

Adult↗
PubMed1981

A modified absorption-reduction method to detect virus-specific hemagglutination inhibiting and neutralizing IgM antibodies.

IgG antibodies are preferentially absorbed by protein A-coupled sepharose beads while most of the IgM and IgA antibodies remain in solution. Even relatively low amounts of virus-specific IgM antibodies can then be detected unequivocally by a decrease of the antibody titer following the treatment with reducing agents. Ethandithiol proved superior to 2-mercaptoethanol in combination with neutralization assays.

Absorption↗
PubMed1980

[Hairy cell leukemia and myeloma].

A woman with morphologically and cytochemically confirmed hairy cell leukemia also showed the typical signs of myeloma (paraproteinemia IgG/k, Bence-Jones-k-paraproteinuria, numerous partly atypical plasma cells in the bone marrow, diffuse osteoporosis of the spine and osteolytic lesions in the skull). This observation strongly supports the hypothesis of a direct relationship between hairy cells and plasma cells.

Aged↗
PubMed1980

[Pericarditis and myocarditis in salmonellosis].

Possible cardiac involvement has been investigated in 103 cases of salmonellosis. 12 patients showed pathological clinical, laboratory and ECG findings suggesting heart damage during the course of the infectious disease. In 2 cases acute fibrinous pericarditis was diagnosed, in 1 case acute effusive pericarditis and in 1 patient acute peri-myocarditis. In the remaining 8 patients the pathological findings suggested the presence of myocarditis. The heart involvement may be the predominating clinical sign, as shown in 3 out of our cases, but in the majority the cardiac symptoms are only very slight. These data indicate that heart involvement is less rare in salmonellosis than is generally thought. On the other hand, salmonellosis should be considered in cases of peri- or myocarditis of unknown origin.

Adult↗
PubMed1980

Cervical thymic cysts in children.

Thymic cysts are a rare cause of cervical masses in children. The cysts usually appear between ages 6 and 7 years and present as a soft swelling in the anterior triangle of the neck. The cysts may be small and unilocular or large and multilocular; they produce few symptoms. The etiology is unclear but may be related to remnants of tissue left in the cervical region when the thymus gland descends from the neck to the mediastinum during embryologic development. Forty-three cases of cervical thymic cysts have been reported in patients under 20 years of age. Two additional cases are reported in boys 5 and 9 years of age.

Age Factors↗
PubMed1980

Peritonitis in patients with liver disease and ascites. Use of Candida albicans as a microbiological clue in differential diagnosis.

Peritonitis in patients with pre-existing liver disease and ascites may be secondary to a local abdominal condition which potentially requires surgery for cure, or alternatively, may be spontaneous in origin. For the latter, antimicrobials are therapeutic while surgery is contraindicated. An easily accessible and important clue for distinguishing these forms of peritonitis may be found in the microbiology of ascitic fluid. Visualization on gram stain smear or recovery on culture of multiple organisms and/or anaerobes favors local abdominal disease over spontaneous peritonitis. The presence of Candida species in the ascitic fluid of such patients, although less common, is highly significant. In the absence of peritoneal dialysis, recent abdominal surgery, or risk factors for disseminated candidiasis, the isolation of Candida suggests specifically gastrointestinal perforation.

Aged↗
PubMed1979

[Unusual autoimmune and neoplastic associated diseases in Sjogren's syndrome].

In an unselected series of 12 patients with Sjögren's syndrome the following autoimmune diseases were observed: severe myxedema due to Hashimotos thyroiditis in four, subclinical thyroid hypofunction in one, diffuse hyperthyroidism in one, glomerulonephritis in two, chronic active hepatitis in one, lupus erythematodes disseminatus in three (one with idiopathic thrombocytopenic purpura), classical rheumatoid arthritis in two. A rare familial occurrence was seen in two sisters. The only male in this group exhibited coexistence of a benign adenolymphoma of the parotid gland (Warthin's tumor) with a malignant non-Hodgkin lymphoma.

Adult↗
PubMed1979

[Familial bradycardia: a family with sick sinus and atrioventricular block].

A kindred is described in which several members have evidence of sick sinus syndrome and of conduction disturbance. The data suggest that in this family the rhythm disturbances were transmitted as an autosomal dominant trait whose penetrance increase with age. The occurrence of Adams-Stokes episodes required pacemaker implantation in 6 patients. In one case the arrhythmia is associated with a cardiomyopathy of unknown origin. No pathological studies were conducted. In one case the His bundle electrogram was recorded.

Adams-Stokes Syndrome↗