Biomedical subjects

M Robertshaw

Publications and source records attributed to M Robertshaw.

3 recordsLinked to original sources

PubMed1993

Protein excretion after prolonged exercise.

Random urine samples were obtained from 16 healthy subjects (nine men and seven women) before and after a 100 Km hill walk for the estimation of total protein, albumin, N-acetyl-beta-glucosaminidase (NAG), retinol binding protein (RBP) and creatinine. The excretion of total protein, albumin and NAG (expressed in relation to creatinine excretion) increased significantly after the walk. The relative clearance of protein and albumin also increased. In four subjects serial measurements were made for 4 days and the excretion of albumin and NAG on the fourth day were similar to the pre-walk values. We conclude that proteinuria of prolonged exercise is at least partly due to reduced tubular reabsorption.

Acetylglucosaminidase↗

PubMed1993

Biochemical changes after a 100 km hill walk.

Biochemical changes after a 100 km hill walk were studied in 16 subjects (nine male and seven female). Plasma concentrations of potassium, albumin and total protein were lower, and the concentrations of phosphate, urea, alanine transaminase (ALT) and bilirubin were higher after the walk than before. Activities of creatine kinase (CK), lactate dehydrogenase (LD) and their isoenzymes CKMB and LD1 increased several fold after the walk. Although CKMB increased, the relative amount of CKMB was less than that seen in myocardial infarction. We conclude that after a 100 km hill walk there is evidence of plasma volume expansion, muscle damage, and increased protein breakdown.

Adult↗

PubMed1989

Prediction of creatinine clearance from plasma creatinine: comparison of five formulae.

1. Glomerular filtration rate is commonly assessed by measurement of endogenous creatinine clearance (CLcr). Several formulae have been described to calculate CLcr from plasma creatinine and we have evaluated the effectiveness of five formulae in 95 healthy subjects (17 F and 78 M, 20-25 years) and in 72 patients attending a renal clinic (48F and 24 M, 14-69 years). Endogenous CLcr was measured and the CLcr was also estimated by five formulae. 2. In healthy subjects CLcr calculated by the formulae of Cockcroft & Gault (1976) and Mawer et al. (1972) gave higher correlation coefficients than the other three formulae. 3. When all of the subjects with a wide range of CLcr (3.1-164) were considered all formulae gave good correlations, but the formula of Cockcroft & Gault (1976) gave the best estimate.

Adolescent↗