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Biomedical subjects

M Robuschi

Publications and source records attributed to M Robuschi.

52 records · Page 3Linked to original sources
PubMed1980

Effects of prostacyclin on aspecifically and specifically induced bronchoconstriction in asthmatic patients.

The efficacy of prostacyclin in preventing aspecifically and specifically induced bronchoconstriction was evaluated in a single-blind cross-over study in 3 groups of asthmatic patients. Prostacyclin was given by inhalation in doses of 250 microgram in women and 500 microgram in men. Ultrasonic mist of H2O (group 1), physical exercise on cycloergometer (group 2) and pneumoallergens (group 3) were used as bronchial stimulant agents. Prostacyclin gave a very good protection in the first 2 groups, but was ineffective in the third. An increase in heart rate was observed immediately after the inhalation of prostacyclin: this effect was particularly evident in women in whom a significant decrease in diastolic pressure was noted too.

Adult↗
PubMed1979

Effect of prostacyclin on antigen induced immediate bronchoconstriction in asthmatic patients.

The effect of premedication with inhaled prostacyclin (PGI2) on the allergen induced immediate bronchoconstriction was investigated in 10 asthmatic patients, under single blind conditions, by means of a body plethysmograph. Statistical analysis (Dunnett's test) did not show any significant difference between PGI2 and placebo. The possible meaning of these results is discussed.

Adolescent↗
PubMed1979

Tolerance of guaiacolic ester of acetylsalicylic acid by patients with aspirin-asthma.

The effects of oral administration of the guaiacolic ester of acetylsalicylic acid (ASA-G) on the ventilatory function were studied by means of a body plethysmograph, in a group of nine ASA-asthmatic patients. No differences in specific airway resistance were observed between ASA-G and placebo. It is concluded that ASA-G is tolerated by patients with ASA-induced asthma.

Airway Resistance↗
PubMed1978

Tartrazine and prostaglandin-system.

Tartrazine, a dye largely employed for colouring foods, drinks, drugs and cosmetics, induces in some aspirin-sensitive subjects a bronchoconstriction similar to that caused by aspirin and other nonsteroidal anti-inflammatory drugs. The interference of tartrazine on prostaglandin system of guinea pig lungs perfused with arachidonic acid has been studied. This compound is able to inhibit in the same manner the formation both of prostaglandins and of thromboxane A2 acting at the cyclooxygenase level as has already been demonstrated for aspirin and indomethacin. Preliminary experiments on aspirin asthmatic patients treated or not with tartrazine are discussed.

Animals↗
PubMed1977

Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic patients.

The behaviour of bronchial reactivity to PGF2alpha was studied in asthmatic patients under various experimental conditions. Premedication with aminophylline, i.v., and, to a lesser extent, with DSCG afforded a partial protection, while beclomethasone dipropionate was inactive under this point of view. Diftalone, a new non-steroid anti-inflammatory agent, was well tolerated in 9 aspirin-intolerant asthmatic patients, and did not modify the bronchial response to PGF2alpha which was found to be generally lower then that of other aspirin-tolerant asthmatic patients. PGE 1-2 and DSCG prevented the bronchospasm induced by inhalation or ingestion of acetylsalicylic acid in a small group of patients. Good protection was also reached with PGE1-2 in the exercise-induced bronchospasm.

Adolescent↗
PubMed1974

[Spontaneous variations of the hematocrit value in chronic bronchopneumopathic patients under medical treatment].

Haematocrit values were studied in chronic bronchitis patients receiving medical treatment during hospitalisation. Both decreases and increases were noted. Statistically significant, they may be regarded as spontaneous, since they occurred in the absence of depletion management. Furthermore, they offer better prognosis for respiratory insufficiency, since they are a pointer to better wash distribution, probably attributable to diminished alveolar hypertension.

Adult↗