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Biomedical subjects

M Rochon

Publications and source records attributed to M Rochon.

At least 19 recordsLinked to original sources
PubMed2006

Impact of biofilm matrix components on interaction of commensal Escherichia coli with the gastrointestinal cell line HT-29.

Commensal Escherichia coli form biofilms at body temperature by expressing the extracellular matrix components curli fimbriae and cellulose. The role of curli fimbriae and cellulose in the interaction of commensal E. coli with the intestinal epithelial cell line HT-29 was investigated. Expression of curli fimbriae by the typical commensal isolate E. coli TOB1 caused adherence and internalization of the bacteria and triggered IL-8 production in HT-29 cells. In particular, induction of IL-8 production was complex and involved curli-bound flagellin. While cellulose alone had no effect on the interaction of TOB1 with HT-29 cells, co-expression of cellulose with curli fimbriae decreased adherence to, internalization and IL-8 induction of HT-29 cells. Investigation of a panel of commensal isolates showed a partial correlation between expression of curli fimbriae and enhanced internalization and IL-8 production. In addition, a high immunostimulatory flagellin was identified. Thus, the consequences of expression of extracellular matrix components on commensal bacterial-host interactions are complex.

Adhesins, Bacterial↗
PubMed1994

[Presentation of a case: encephalopathy of boxers].

A 68-year-old man presents slight memory problems and behavioural change over a period of a year. A history of boxing is identified. Neuropsychological examination confirms slight frontal cognitive damage and damage at the level of the motor signs of the upper left hemicorpus. This symptomatology should, in differential diagnosis, raise the possibility of chronic punch-drunk syndrome. Further studies should be done to better document this little-characterized clinical entity and arrive at a clearer definition of this syndrome.

Aged↗
PubMed1991

[Tubal ligation and vasectomies in Quebec. Recent trends].

The author analyzes recent trends in the number of tubal ligations and vasectomies performed in Quebec, Canada, using data for cohorts born since 1941. She finds that since the early 1980s, there has been "a decrease in the proportion of sterilized females and an increase in the proportion of sterilized males.... On the whole, the number of sterilized couples in their thirties has slightly decreased.... The most recent data seem to indicate that this evolution has come to a halt." (SUMMARY IN ENG AND SPA)

Americas↗
PubMed1989

[The current reproductive life of women. The Quebec case].

The author reviews the current reproductive patterns of women in the province of Quebec, Canada. "Through birth control and family planning, Quebec women experience an average of two pregnancies and give birth to 1.7 children. Sexual life is not reserved any more to married women, and starts at an increasingly early age. The percentage of teenagers experiencing a pregnancy is increasing. The rate of induced abortion is the highest at age 18-24. From the age of 18, more than half of the young women use oral contraceptives. The most educated women have the smallest number of pregnancies; they start their marital and reproductive life later than other women, and declare a larger percentage of induced abortion. Less educated women resort however to sterilization at an earlier age." Data are from the Quebec Health Survey of 1987 and other official sources. (SUMMARY IN ENG AND SPA)

Abortion, Induced↗
PubMed1989

Enhanced DNA cross-link removal: the apparent mechanism of resistance in a clinically relevant melphalan-resistant human breast cancer cell line.

Resistance to the cytotoxic effects of alkylating agents is a major limitation to their clinical efficacy. Although a number of animal and human tumor cell models have been developed to study this problem, it has proven difficult to achieve very high levels of resistance to alkylating agents in vitro. This is consistent with the recent clinical evidence that alkylator resistance can be overcome by dose escalations of less than 10-fold. A number of mechanisms of alkylator resistance have been described, more than one of which may occur in the same model. This paper describes a human breast cancer cell subline selected for 3-fold resistance to melphalan and cross-resistant to other alkylators in which only one of the previously described mechanisms of resistance, enhanced removal of DNA interstrand cross-linking, is demonstrable. Northern blot analysis using the human incisional repair gene ERCC-1 cDNA demonstrated that this particular gene product is not the altered function in these cells, so the molecular characterization of the observed enhanced repair is pending. Because these cells are also cross-resistant to radiation and to adriamycin and epipodophyllotoxin, they may represent a clinically relevant model in which to examine the role of DNA repair of lesions resulting from alkylators and other cytotoxic agents.

Blotting, Northern↗