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Biomedical subjects

M Rodgers

Publications and source records attributed to M Rodgers.

26 records · Page 2Linked to original sources
PubMed1981

Serum lipids in a teenage population: geographic, seasonal and familial factors.

The lipid results of a cross-sectional study of cardiovascular disease risk factors in over 600 13-18 year olds drawn from general practices in contrasting areas are reported. Differences were noted between the 3 practices, including a significant variation in the blood group distribution. HDL cholesterol showed a marked variation between the 3 practices which was unlikely to be due solely to seasonal variation. Alcohol consumption though not an univariate correlate of HDL cholesterol was however a strong partial correlate, as were age, height, sexual maturation, adiposity and smoking. Using 6 factors in each sex, 13% of the interchild variance of HDL cholesterol in boys could be explained in a multiple linear regression analysis, and 8% in girls. Including the practice variation as a further independent variable increased the explanation in 18% in boys and 15% in girls. An intraclass correlation (sib-sib) of 0.36 was found for HDL cholesterol, suggesting a strong familial influence. The implications of these results are discussed, along with the difficulties of screening for hyperlipidaemia in this age group.

Adolescent↗
PubMed1980

Changes in blood lipids and blood pressure during adolescence.

A total of 625 adolescents from three general practices participated in a cross-sectional study of cardiovascular disease risk factors. The girls had higher serum total and high density lipoprotein (HDL) cholesterol concentrations than the boys, while the boys had higher serum triglyceride concentrations. Smoking (equally prevalent in both sexes) was associated with lower HDL cholesterol concentrations, particularly in boys, while in girls use of oral contraceptives was associated with higher total cholesterol and lower HDL cholesterol concentrations showed striking associations with age, height, and sexual maturation in boys, but not in girls. Triglyceride concentrations were associated with age in boys. Systolic blood pressure and serum urate concentrations were higher in boys and rose steeply with age, but no age association was seen for urate concentrations or systolic blood pressure in girls or for diastolic pressures in either sex. Girls, however, had higher diastolic pressures. There was a strong association between urate concentration and the other cardiovascular disease risk factors, especially HDL cholesterol. Adolescence is associated with considerable changes in cardiovascular disease risk factors, and there are striking sex differences in these changes.

Adolescent↗
PubMed1980

Two new non-barbiturate buffers for electrophoresis of serum proteins on cellulose acetate membranes.

Two new non-barbiturate buffers have been formulated for serum protein electrophoresis on cellulose acetate membranes. Both buffers give five distrinct fractions and are suitable for all systems, but have been primarily designed to meet the needs of the Gelman "Sepratek" system. One buffer is a tris(hydroxymethyl)aminomethane (Tris)/hippurate formulation; the other is composed of Tris/N-[tris(hydroxymethyl)methyl]glycine (Tricine)/sodium chloride/sodium salicylate. Both buffers allow reliable quantitation of protein fractions, giving results that correlated well with those obtained from barbiturate separations. The major advantage of these buffers is that they do not contain drugs of abuse.

Barbiturates↗
PubMed1976

Can digoxin dose requirements be predicted?

A search for patient variables relevant to digoxin dose requirements was made in fourty-three patients with a wide range of renal and hepatic function. The daily dose of digoxin to achieve a mean serum concentration of 1.5 ng/ml, the standardized dose, was calculated for each patient. The standardized dose correlated significantly with the following variables, in descending order of correlation coefficient; creatinine clearance, serum creatinine concentration, body weight and serum albumin concentration. An equation containing the two independent variables, creatinine clearance and serum albumin concentration, had a significantly stronger correlation with standardized dose than creatinine clearance alone. Attempts were made in each patient to predict the standardized dose using both empirical prescribing methods and the published nomograms. Although a maximum of 70% of the variance of the standardized dose was explained, this corresponded approximately to one patient in three having a predicted dose outside the 95% confidnece limits for the standardized dose. There remain important sources of individual variation in digoxin dose requirements yet to be identified. Future application of empirical prescribing methods, such as multiple linear regression and Bayes' theorem, to prescription for large, defined patient groups may improve dose prediction for individual patients.

Digoxin↗