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Biomedical subjects

M Rodríguez Portillo

Publications and source records attributed to M Rodríguez Portillo.

12 recordsLinked to original sources
PubMed2003

[Valoration of the FAS in the contralateral testis after unilateral testicular torsion. Experimental study in rats].

The role the FAS and BCL-2 in the apoptosis of testicular cells in the contralateral testis after unilateral testicular torsion, was investigated. We compared with control group. These experiments were performed in male Wistar rats prepuberal old. FAS and BCL-2 determination is realized in cells cultures of contralateral testis. Flow cytometry and immunohistochemistry studies, using a FAS and BCL-2 specific monoclonal antibody, were utilized to value FAS y BCL-2 expression on testiculaires cells following unilateral testicular torsion. We observed an increase of expression of FAS and decrease of BCL-2 in the contralateral testis in comparison with control group. The present results may indicate that the expression of this molecules is implicated in cellular apoptosis.

Animals↗
PubMed2000

[Apoptosis of the contralateral testis after unilateral testicular injury. Experimental study].

INTRODUCTION: The results of both clinical and experimental studies suggest that some testicular unilateral lesions cause infertility due to disruption of spermatogenesis. The cellular mechanism responsible for the degenerative changes is still unclear. OBJECTIVE: Study of the cellular viability in the contralateral testis after unilateral testis injuries. MATERIAL AND METHOD: Six groups of 10 prepuberal Wistar rats subjected to unilateral testicular lesion. To identify the cellular death by "apoptosis" in situ, analysis of DNA fragmentation was performed in cytometric flow. RESULTS: The present study demonstrated an increase of the apoptosis in the contralateral testis after unilateral testicular lesion.

Animals↗
PubMed1979

[Influence of the albumin fraction in the plasma oncotic pressure (author's transl)].

This work analyzes the influence which albumin fraction exerts upon plasma oncotic pressure. With this objective three different groups were studied, each one of which was composed of subjects with identical total proteinemia and variable albuminemia. The first group: nine subjects with 6.2 g/100 ml proteinemia and albumin values between 3.2 and 3.8 g/100 ml; the second group: seven healthy subjects with 6.4 g/100 ml proteinemia and the level of albumina between 3 and 4 g/100 ml; the third group: subjects with proteinemia at 6.6 g/100 ml and extreme values of albumin between 3.1 and 4.3 g/100 ml. Plasma oncotic pressure was determined by means of an electronic osmometer, according to the described technique. With a proteinemia constant at 6.2 g/100 ml, a 0.6 percent fluctuation of the albumin concentration induced a variation in the plasma oncotic pressure of up to 20.4 per cent. In cases of proteinemia remaining constant at 6.4 g/100 ml, the oscillation of albumin levels between 3 and 4 g/100 ml represented a change in the plasmatic oncotic pressure of 32.58 per cent. In the third group, the influence of the albuminemia was lesser (23.1 per cent variability in the plasma oncotic pressure, with an oscillation of 1.2 g/100 ml in albuminemia). The existence of variable values of plasma oncotic pressure corresponding to cases with identical proteinemia and albuminemia, lead us to consider the powerful influence exerted upon the plasma oncotic pressure by other factors which affect the mass-structure and the electrical charges of proteins.

Blood Pressure↗
PubMed1979

[Iatrogenic gastrointestinal hemorrhages. A review of 108 cases (author's transl)].

Macroscopic gastrointestinal hemorrhages caused by the consumption of oral drugs are relatively scarce among patients receiving antirheumatic treatment. On the other hand, in a high percentage of all cases of digestive bleeding, antirheumatic drugs were administered shortly beforehand. A review of 216 cases with hematemesis and/or melena are presented. In 50 percent of the patients there was evidence of previous administration of potentially ulcerogenic drugs capable of causing hemorrhages in the digestive tract. Salicylates predominated among the compounds that were considered to be responsible for hemorrhages (salicylates, corticosteroids, reserpine, and other antirheumatic products). The mechanisms involved in producing iatrogenic hemorrhages were examined and the drugs were classified as precipitating and directly ulcerogenic compounds. Precipitating drugs were those which were able to reactivate a preexisting lesion (reserpine, glucocorticoids, phenylbutazone, etc.). The ulcerogenic drugs included those products that could provoke a lesion of previously unimpaired digestive mucosa (salicylates).

Anti-Inflammatory Agents↗