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M Roglev

Publications and source records attributed to M Roglev.

12 recordsLinked to original sources
PubMed1997

Application of polygenic threshold models in the etiology of affective disorders.

Multiple studies show that familial transmission of affective disorders does not conform to the classical principles of Mendelian inheritance. With the purpose of testing polygenic threshold models of inheritance of affective disorders, a study was carried out on 1184 probands with affective disorders with secondary cases in their families (siblings and offspring). Nonparametric analysis (Chi square test) indicates that there is no statistically significant difference between the observed and expected frequencies of secondary cases, when the probands are divided into two subgroups--unipolar and bipolar. It is proved that the two forms have common etiologic factors and the clinical differences between them can be attributed to the threshold gene effects. The hypothesis that bipolar and unipolar disorders are respectively severe and mild forms of the same disorder and that the two-threshold multifactorial polygenic model most adequately predicts the familial transmission of affective disorders is accepted.

Bipolar Disorder↗
PubMed1997

Multidimensional classification of affective disorders.

Research data on biological markers, clinical presentation and course of affective disorders justify proposal of a new multidimensional classification of these disorders. The classification is made according to six parameters: clinical picture, severity, course, duration of episodes and lucid intervals, etiology and premorbid personality. The clinical picture defines the predominant syndrome types and subtypes. The severity of the disease is graded as mild, moderate and severe. The course type includes two subgroups: unipolar and bipolar. The fourth parameter gives the duration of the episodes and lucid intervals and the criteria for chronicity of the disorder. The etiological parameter assesses the relative contribution of endogenous, exogenous and psychogenic factors in the etiology. The personality of the patient is classified into three types: normothymia, monothymia (dysthymia, hyperthymia) and bithymia (cyclothymia).

Bipolar Disorder↗
PubMed1976

[Comparative investigations of psychoses in parents, children and siblings (author's transl)].

Psychoses in 441 hospital patients from 210 families have been investigated comparatively. In 106 families 109 parents and 117 children suffer as do 215 siblings in 104 families. It has been established that the sexual appurtenance does not have a decisive importance in the genetic transmission of the psychoses, while comparing the diagnoses, a high percentage (84.5%) of coincidence is founded. Similarities appear in the clinical features, in their course, and the therapeutical effect. The psychoses begin at an earlier age and are taking a heavier course in children, when compared to parents and in the younger brothers and sisters when compared to the elder. In couples with different diagnoses, a similarity is determined as far as the investigated indices are concerned. The clinical features are atypical and symptoms and syndromes, characteristic for the different families, are manifested.

Adjustment Disorders↗