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Biomedical subjects

M Rollins

Publications and source records attributed to M Rollins.

10 recordsLinked to original sources
PubMed1993

Comparison of clinical responses to natural and synthetic surfactants.

The clinical responses to both natural and synthetic surfactants were observed in two District General Hospital Neonatal Units who were centrally randomised as part of two separate multicentre trials (OSIRIS and Curosurf 4). Forty five infants were enrolled consecutively in the OSIRIS trial using synthetic surfactant (Exosurf), while 21 infants were subsequently enrolled in the Curosurf 4 trial using natural surfactant (Curosurf). There were no significant differences between the groups for mean birth weight, gestational age, inspired oxygen (FiO2), or arterial: alveolar oxygen ratio (a/A) prior to surfactant administration. Oxygen requirements fell significantly more rapidly within the first 24 hours for patients treated with Curosurf compared to Exosurf (p < 0.001). Mean duration of > 40% oxygen requirement was significantly shorter in the Curosurf group (2.6 days) compared to 8.0 days in the Exosurf group (p < 0.01). Mean duration of oxygen therapy was also significantly shorter in the Curosurf group (10.2 days) compared to 17.1 days in the Exosurf group (p < 0.05). Ten infants (24%) in the Exosurf group developed intraventricular haemorrhage (IVH) compared to none in the Curosurf group (p < 0.05). As oxygen requirements appear to decrease more rapidly following administration of Curosurf compared to Exosurf a large prospective randomized multicentre trial needs to be performed to compare the effects of these surfactants on both short and long-term outcome.

Arteries↗
PubMed1986

Prospective comparison of exercise digital subtraction and exercise first pass radionuclide ventriculography.

In order to test the comparative sensitivities of first-pass radionuclide and digital subtraction ventriculography in detecting wall motion abnormalities during exercise, 29 patients referred for coronary angiography were submitted to both types of stress ventriculograms. Resting and exercise ventriculograms by both techniques were reviewed by independent observers and the five equal ventricular wall segments were graded as normal, mildly, moderately, severely hypokinetic, akinetic, or dyskinetic. Of the 29 patients, 24 had arteriographically defined ischemic potential (at least greater than 50% obstruction of a major coronary artery supplying viable myocardium). Exercise digital subtraction ventriculography correctly identified 17 (71%) of these by a worsening of wall motion during exercise, while radionuclide ventriculography identified only eight (33%) by the wall motion response. When either a worsening of wall motion or the failure to increase ejection fraction by at least 5 points were used as criteria for an abnormal test, the sensitivities of digital and radionuclide ventriculographies were 96% and 79%, respectively. Though the number of patients without ischemic potential (5 patients) was too small to judge the relative specificities, digital subtraction ventriculography appears to be more sensitive than radionuclide ventriculography in identifying exercise-induced wall motion abnormalities and in predicting coronary occlusions.

Angiography↗
PubMed1986

Epidural analgesia for total hip replacement in a patient with dilated cardiomyopathy.

A 69-year-old patient with severe impairment of left ventricular function secondary to dilated cardiomyopathy underwent a successful total hip replacement under epidural analgesia. Perioperative heart rate and mean arterial pressure were stable at an analgesic level up to the seventh thoracic dermatome, achieved with mepivacaine two per cent with epinephrine. Asymptomatic pulmonary hypertension, occurring during the insertion of the femoral prosthesis, subsided spontaneously over the next twelve hours. The circulatory effects of epidural analgesia and their significance in a patient with dilated cardiomyopathy are discussed.

Aged↗
PubMed1985

Comparison of stress digital ventriculography, stress thallium scintigraphy, and digital fluoroscopy in the diagnosis of coronary artery disease in subjects without prior myocardial infarction.

Exercise thallium scintigraphy is often used for the diagnosis of coronary artery disease (CAD). Exercise digital subtraction ventriculography and digital subtraction fluoroscopy are new diagnostic procedures with roles that have not been determined. To compare the relative accuracies of the digital techniques with thallium scintigraphy, 97 consecutive patients without myocardial infarction underwent all 3 tests on the day before their scheduled coronary angiograms. Forty-two patients had CAD (more than 50% diameter narrowing of 1 major artery). A fixed or reversible perfusion defect defined an abnormal thallium test response and a segmental wall motion abnormality at rest or with exercise defined an abnormal digital ventriculographic response. Any visualized coronary calcific deposit defined an abnormal digital fluorographic response. The sensitivities of digital fluoroscopy (86%) and digital ventriculography (79%) were significantly higher than the sensitivity of thallium (62%) (p less than 0.05). The specificity of thallium (82%) was not significantly higher than that of either digital ventriculography (72%) or fluoroscopy (67%). The diagnostic accuracies of digital fluoroscopy, digital ventriculography, and thallium were 75%, 75% and 73%, respectively. A logistic regression model showed that thallium and digital fluoroscopy were more accurate in younger patients, whereas digital ventriculography was more sensitive in hypertensive persons and in those not taking beta-blocking drugs. The choice of test depends on disease prevalence, clinical variables (such as age and hypertension) and the importance of functional information obtained from stress testing.

Age Factors↗
PubMed1977

The immune response of calves given Mycoplasma bovis antigens.

Seven calves seven to 30 days of age were given Mycoplasma bovis antigen by different routes. Immunization was in two phases. The first consisted of single or multiple SC, IV or oral doses of antigen for two to four weeks. The second phase consisted of multiple SC or ID injections given from the eighth to the 19th week. The experiment was terminated at 26 weeks. Antibody titers were followed by indirect hemagglutination, growth inhibition and tetrazolium reduction inhibition. Total serum protein, protein fractions and IgG and IgM concentrations were determined in serums of one calf and the distribution of indirect hemagglutination antibodies in IgG and IgM classes were determined in serums of two of the calves. Indirect hemagglutination titers of 1280 and peak titers of >20,480 occurred after the first and second phases respectively. There was no relationship between total serum IgG or IgM concentrations and indirect hemagglutination titers. In one calf given M. bovis antigen in one dose SC and five weekly doses IV in phase I, indirect hemagglutination antibodies appeared in IgM within one week and IgG by four weeks, IgG antibody activity rose steadily until the 17th week but declined at the 26th week, whereas IgM activity after the initial rise dropped at the 13th week but rose even higher as a result of second phase ID injections. Another calf given six weekly IV doses of M. bovis antigen in phase I developed indirect hemagglutination antibodies in IgM peaking at four weeks then declining but with no IgG response. Activity in both IgM and IgG occurred after the second phase. Growth inhibition antibodies were found only on two occasions in one calf serum and tetrazolium reduction inhibition activity when tested never gave titres exceeding 1:32.

Administration, Oral↗
PubMed1976

Interfacing a programmable desk calculator to a hard-wired data system.

The primary disadvantage of hard-wired data systems for use in nuclear medicine is the fact that that the data contained in the memory bank are not accessible to the user and often must be processed mathematically before they can be employed in interpretation, particularly in dynamic studies. The authors describe a relatively inexpensive programmable device which can be used in conjunction with the data system and overcomes these limitations to a great extent.

Blood Flow Velocity↗
PubMed1976

The immune response of rabbits to 3 strains of Mycoplasma agalactiae var. bovis isolated from mastitic bovine udders.

Rabbits were given 3 serologically-related trains of mycoplasma isolated from mastitic bovine udders. Growth inhibiting antibodies were not found. High-titered sera from each rabbit immunized with each strain developed at least 4 precipitin lines to each organism and at least one line of identity was demonstrated between the organisms. Significant indirect hemagglutination titers were found in all rabbits in 1 week, with titers reaching 1.0 X 10(5) to 3.3 X 10(5) in 4 to 6 weeks but despite continued intravenous antigenic stimulation, titers quickly fell to low levels thereafter.

Animals↗