PubMed Health⌕ Search

Biomedical subjects

M Romo

Publications and source records attributed to M Romo.

At least 37 records · Page 2Linked to original sources
PubMed1987

Comparison of the levels of cardiovascular risk factors between eastern and south-western Finland in 1982.

Altogether 6,523 persons aged 25-64 years were studied in eastern and south-western Finland to determine their cardiovascular risk factor levels. Among men, smoking was more prevalent in the south-western area (41 vs. 37%), serum cholesterol levels were higher in the eastern area (6.2 vs. 6.0 mmol/l) and blood pressure levels were the same in both areas (145/86 in the east vs. 144/86 in the south-west). Among women, smoking was also more common in the south-western area (24 vs. 16%) and serum cholesterol levels were higher in the eastern area (6.1 vs. 6.0 mmol/l) as well as blood pressure levels (142/84 vs. 138/81 mmHg). Among both genders, prevalence of hypertension and proportion of persons on antihypertensive drug therapy was higher in eastern Finland. The comparison of these findings with the results from previous studies carried out among men in these two areas indicates that the risk factor levels have been decreasing in both areas and that the previously observed differences in risk factor levels between eastern and south-western Finland (the levels used to be higher in the east) have levelled off. The favourable development in eastern Finland may be a result of the North Karelia Project.

Adult↗
PubMed1986

Levels of some biological risk indicators among elderly men in Finland.

A 25-year follow-up survey of the Finnish men examined in the Seven Countries Study and now 65-84 years old was carried out in the East and the South-West of Finland in 1984. The follow-up examinations were carried out as in the previous surveys. Systolic and diastolic blood pressures were now significantly lower in the East than in the South-West of Finland. Serum total cholesterol and HDL-cholesterol were on the same level in both areas. The East/South-West difference in serum cholesterol, observed in previous studies, had levelled off and that in the blood pressure level had even reversed among the study cohorts. The mean fasting serum glucose was higher in the East than in the South-West of Finland. The mean serum calcium level was the same in both areas.

Aged↗
PubMed1985

Changes in incidence and prognosis of ischaemic heart disease in Finland: a record linkage study of data on death certificates and hospital records for 1972 and 1981.

The components of the decline in mortality from ischaemic heart disease in Finland were studied by analysing the changes in incidence and prognosis between 1972 and 1981. Using personal identification numbers, hospital discharge records and death certificates were linked for all men and women aged 40-64. During this period mortality decreased 15.9% in men and 23.5% in women, incidence 14.2% in men and 19.3% in women, being greatest among 40-49 year olds living in urban areas, and case fatality 7.3% in men and 10.3% in women, owing primarily to a decrease in patients dying of ischaemic heart disease without being admitted to hospital; survival was also better among patients admitted to hospital. Factors explaining these changes remain unknown because data on risk factors and factors influencing prognosis are limited and largely ecological.

Adult↗
PubMed1985

The declining trend in the incidence of acute myocardial infarction in Finland. The results of Helsinki Coronary Register during 1970-1977.

The results from Helsinki Coronary Register during the period 1970-1977 show that the incidence of acute myocardial infarction (AMI) among people under 65 years of age reached its peak in 1972 and declined annually by 2.8% from 1972 to 1977. The trend was clearest in patients under 50 years, but statistical analysis showed that no 5-year age group, either in women or men, differed statistically significantly from the general declining trend.

Adult↗
PubMed1982

Incidence and prognosis of ischemic heart disease with respect to geographical area. An epidemiological study of middle-aged Finns.

Ischemic heart disease is more common in East Finland than in West Finland, but systematic comparison and follow-up of incidence figures have not been possible. In 1972 the personal identification number became included in the hospital discharge records, which made it possible to link death certificate data with hospital records from the whole country. The results of this study suggest that high mortality from IHD in some regions is more closely associated with high incidence than a high fatality rate. The proportion of deaths outside hospitals showed large variation by province but this had rather little effect on the total one-year survival rates.

Adult↗
PubMed1981

Incidence and prognosis of ischaemic heart disease with respect to marital status and social class. A national record linkage study.

Increased mortality from ischaemic heart disease (IHD) has been found in previous studies among divorced, widowed, and unskilled middle-aged Finnish men. In this study all cases of IHD in men aged 40-64 during 1972 were analysed by linking death certificates and hospital records (7499 cases with 3136 deaths). Age-adjusted incidence, mortality, and survival rates of the first and third year were calculated by marital status and social class. The highest mortality rate was found among unskilled workers, the highest incidence among widowers and those in the lower professional classes, and the lowest survival rate among divorcees, single persons, and unskilled workers. The ratio of mortality by marital status (1.77) was in part due to survival (ratio 1.44) and in part due to incidence (ratio 1.32). The ratio of mortality by social class (1.44) seemed to be due more to differences in incidence (ratio 1.36) than to differences in survival (ratio 1.18). The distribution of conventional risk factors of IHD by marital status and social class seems to explain only part of the mortality differences.

Adult↗
PubMed1981

Clinical trial of a subunit influenza vaccine.

A double-blind field trial was performed comparing a subunit influenza vaccine (A/Victoria/75 and B/Hongkong/73) with placebo. A good protection against influenza was induced by the vaccine. On the basis of serological determinations (enzyme immunoassay, EIA) the incidences of influenza A and B infections were reduced within a period from 3 weeks up to 5 months after the vaccination by 88 and 68%, respectively. Three weeks after the vaccination 79% of the vaccines had acquired protective serum antibody levels (greater than or equal to 32 x 10(2) by EIA) against influenza A and 62% against influenza B, while in the control subjects protective antibody levels were measured in frequencies from 4 to 13% in subsequent serum samples. With a few exceptions antibody levels were still present in 5-month samples. Side effects were recorded within the first 3 days following the vaccination. Some minor symptoms like redness and tenderness at the vaccination site and muscle ache were reported more frequently by the vaccines than by the controls, but no more harmful systemic reactions.

Adult↗
PubMed1980

Five-year survival of 728 patients after myocardial infarction. A community study.

This study deals with the five-year survival of 728 myocardial infarction patients who survived the first 28 days after the onset of symptoms. The series was collected by the Helsinki Coronary Register and includes all cases of acute myocardial infarction in the population who were under 66 years of age during the period 1 July 1970 to 30 June 1971. Of the 219 patients who subsequently died, 81.8 per cent died from ischaemic heart disease. The mortality was highest during the first year after the acute phase but did not decrease after the second year. The mortality was higher in patients with a transmural infarction (five-year mortality 34.0%) compared with those with a nontransmural infarction (19.7%). The mortality also was higher for recurrent acute myocardial infractions than for first attacks. The five-year mortality for women was less (20.5%, age-adjusted) than for men (31.6%). This is mainly because of the higher incidence of nontransmural infarcts in women. Acute ischaemic heart disease is more common, more often fatal, and has a poorer long-term prognosis in men than in women in Helsinki. The acute mortality from acute ischaemic heart disease is high in Helsinki when compared with other WHO registers and, in addition, the long-term prognosis seems to be relatively poor in Helsinki.

Adult↗
PubMed1979

The prognostic value of the P wave morphology in the discharge ECG in a 5-year follow-up study after myocardial infarction.

The discharge ECG's of 641 patients with acute myocardial infarction (AMI) (WHO categories "definite" and "possible" AMI) were studied to assess the prognostic value of P wave morphology as an index of left ventricular dysfunction. Of 69 patients with abnormal P terminal force (PTF), i.e., --0.03 mm.sec. or more negative, 53.6 per cent died within the next 5 years of ischemic heart disease, compared with 20.4 per cent of 558 patients with normal PTF. The odds ratio (age-corrected risk to die, Mantel-Haenszel test) was 4.1 (95 per cent confidence limits 2.4 to 7.0). The mortality curve of patients with normal PTF was linear whereas there was an abrupt rise in mortality rate during the first six months if PTF was abnormal. Of a group of 15 patients with the frontal axis of the terminal P wave --30 degrees or more negative, 8 died (Odds ratio 4.7; 1.3 to 17.1). Ten patients had atrial fibrillation, and five of them died (Odds ratio 2.; 0.5 to 12.9). In 14 cases the duration of the P wave in Lead II was 0.12 sec. but it showed no relationship to mortality (p less than 0.10). The significance of the P wave morphology on the discharge ECG to long-term survival after MI has been demonstrated. These simple ECG variables, related to left ventricular failure, can easily be put to clinical use to differentiate MI patients who are in greater risk of dying during the chronic phase.

Aged↗
PubMed1979

Labetalol and pindolol in the treatment of hypertension: a comparative study.

Labetalol, a new hypotensive drug with both alpha- and beta-adrenoceptor antagonist properties, was compared with pindolol in a double blind cross-over study lasting 15 weeks. Both drugs caused a significant drop on blood pressure in both the standing and the supine position. The effect was seen after only two weeks treatment. The effect on the pulse rate was moderate. Three patients on pindolol (but none on labetalol) had to withdraw from the trial for medical reasons. In general the side effects recorded for labetalol and pindolol were mild. No postural hypotension was noticed with the moderate doses used in the study. Labetalol seems to be at least as effective as pindolol in mild to moderate hypertension.

Adult↗