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Biomedical subjects

M Ron

Publications and source records attributed to M Ron.

At least 127 records · Page 7Linked to original sources
PubMed1982

Fetal heart rate decelerations following the administration of meperidine-promethazine during labor.

A deceleration response lasting up to 7 min was observed in 53 fetuses (out of 1910 studied) following the administration of 75 mg meperidine and 25 mg promethazine intravenously to the mothers during labor. Thirty-six of these fetuses reacted with baseline tachycardia following the deceleration with or without loss of baseline variability. Seven fetuses showed a variable deceleration pattern and six fetuses reacted with a late deceleration pattern following the first deceleration. Two newborns from the group showing a late deceleration pattern were delivered with an apgar score below 7 in 5 min. The probable mechanisms and significance of these changes are discussed.

Anesthesia, Obstetrical↗
PubMed1982

The clinical significance of blood-contaminated midtrimester amniocentesis.

In 706 midtrimester amniocenteses, 180 (25.5%) samples yielded blood-stained amniotic fluid (macroscopically and microscopically), 152 (21.5%) contained maternal blood, 28 (3.9%) fetal blood and 8 samples contained both maternal and fetal blood. In the 180 cases of bloody midtrimester amniocentesis, the abortion rate was 6.6% when maternal blood was found and 14.3% when fetal blood was aspirated, compared with 1.7% in controls. The amount of blood drawn did not alter pregnancy outcome. The percentage of blood amniotic fluid in amniocenteses performed before the 16th week of pregnancy was much higher (36.7%) than during and after the 16th week of pregnancy (22%). Midtrimester amniocentesis should therefore be avoided before the 16th week of pregnancy.

Amniocentesis↗
PubMed1982

Dissociation between sleep-related and TRH-induced prolactin secretion in seminiferous tubule failure.

Prolactin (PRL) secretion has been measured during sleep and following TRH administration in 8 patients aged 24-39 yr with seminiferous tubule failure and 36 controls. Basal LH levels were 25.7 +/- 14.7 mIU/ml in the patients compared to 11.5 +/- 4.2 mIU/ml in the controls (p less than 0.01) Corresponding FSH levels were 26.2 +/- 10.7 mIU/ml and 5.9 +/- 2.1 mIU/ml (p less than 0.001) Mean estradiol 17B and testosterone levels were similar in the 2 groups. The mean PRL secretion during sleep was 16.5 +/- 11.7 ng/ml in the patients and not different in 11 of the controls (12.4 +/- 3.2 ng/ml). One patient had a mean nocturnal PRL concentration of 44.1 ng/ml. In both groups, the mean sleep related PRL concentration was greater than that during waking hours. The average number of peaks in the 2 groups was similar. In the same patients, the peak PRL response to TRH (200 ug IV) was 81.9 +/- 18.8 ng/ml as compared to 32.1 +/- 10.7 ng/ml in the controls (p less than 0.001). It is concluded that PRL concentrations following pharmacological stimulation are increased in seminiferous tubule failure, whereas levels are normal in relation to the physiological stimulus of sleep.

Adult↗
PubMed1981

Prolactin concentration in prostates with benign hypertrophy.

Twenty-two hypertrophied prostates removed in surgery were checked for prolactin concentration by the radioimmunoassay method. The mean concentration in the prostatic tissue was found to be 38.2 +/- 1.9 ng./Gm. while the mean basal serum level was 11.9 +/- 1.3 ng./ml. It is concluded that serum prolactin levels do not reflect prostatic prolactin concentration. The possibility that interrelationship in action exists between androgens and prolactin affecting each other's concentration, both influencing prostatic metabolism is discussed.

Aged↗
PubMed1980

The action of bromocriptine on human detrusor muscle.

The pharmacological effects of bromocriptine on human detrusor muscle were investigated by an in vitro isometric method. Both a direct stimulating effect and an anticholinergic effect were demonstrated. These effects, together with an alpha-adrenergic blocking effect reported in a previous paper, are correlated with the published clinical effects of bromocriptine in patients with primary and secondary unstable detrusors.

Bethanechol Compounds↗
PubMed1980

Serum prolactin levels in men during retropubic prostatectomy.

Thirty-one patients who underwent retropubic prostatectomy under epidural anesthesia for benign hypertrophy of the prostate were checked for serum prolactin levels before and during operation. A significant increase in serum prolactin levels was noted during operation after the removal of the prostate, as compared with levels just prior to its removal. This difference suggests high concentration of prolactin in the prostatic tissue, part of which was released into the bloodstream during the traumatic squeezing of the prostate.

Humans↗
PubMed1980

Exaggerated prolactin response to thyrotropin-releasing hormone and metoclopramide in primary testicular failure.

Twenty-eight severely oligospermic and azoospermic men aged 20 to 42 years were challenged with luteinizing hormone (LH)-releasing hormone (LHRH), thyrotrophin-releasing hormone (TRH), and the dopaminergic antagonist, metoclopramide, given at 30-minute intervals. According to basal gonadotropin levels, the patients were subdivided into three groups: those with severe testicular failure (basal LH > 20 mIU/ml and FSH > 14 mIU/ml); those with moderate testicular failure with predominant seminiferous tubule involvement (LH < 20 mIU/ml and FSH > 14 mIU/ml) and those with mild testicular failure (LH < 20 mIU/ml and FSH < 14 mIU/ml. With one exception, mean basal prolactin (PRL) levels were normal in all patients. In all three groups, however, there was an exaggerated PRL response to TRH, the response in severe and moderate testicular failure being greater than that in mild testicular failure. The response to metoclopramide was increased only in the first two groups, not in the group with mild testicular failure. When individual patients and control subjects were considered together, the peak PRL response to TRH correlated with both basal and peak gonadotropin responses to LHRH. However, the PRL responses did not correlate with 17 beta-estradiol, estrone, testosterone, or the estradiol-testosterone ratio. It is concluded that oligospermic and azoospermic subjects with the most severe testicular failure and the highest gonadotropin levels have the greatest PRL increases after TRH and metoclopramide, indicating that the PRL response is related to the degree of testicular failure.

Adult↗
PubMed1980

Extramembranous pregnancy: maternal, placental, and perinatal implications.

The case of a patient who survived extramembranous pregnancy is presented, and the maternal, fetal, placental, and neonatal features of the condition are described and delineated. Previously underscribed phenomena include clinical evidence of fixed fetal position and a unique pattern of hemosiderin and hematoidin staining of the fetal membranes. The patient described had an intermediate form of the oligohydramnios tetrad following premature rupture of the membranes; the infant survived with respiratory support therapy in spite of apparent partial lung hypoplasia. On the basis of this and previous observations of the outcome of pregnancy complicated by prolonged amniotic fluid leakage, preliminary recommendations for the management of such pregnancies are made.

Abruptio Placentae↗
PubMed1980

A simple technique for visualization of the vagina during ultrasound scanning.

A simple method for clear visualization of the vagina during ultrasound scanning is described. A sealed cylinder, filled with water, is introduced into the vagina. This device, used when the urinary bladder is full, improves visualization of the pelvic organs and facilitates interpretation of the scans. The technique may be employed during all stages of pregnancy, provided there is no bleeding or dilatation of the cervix.

Female↗