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Biomedical subjects

M Rossetti

Publications and source records attributed to M Rossetti.

At least 19 recordsLinked to original sources

[Effect of polyunsaturated fatty acids on experimental ulcer in the rat].

The increase of gastric mucosal defensive reachons under linoleic acid loading (20 mg/kg i.m. x 2 x 10 die; 140-220 mg/kg per os x 2 x 15 die), was evaluated in hydrocortisone treated rats (10 mg/kg i.m. x 2 x 10 die) and in rats stressed by immobilisation at a low temperature (at 4 degrees for 1 hour). The incidence and extent of gastric lesions were recorded, in both samples treated differentialy, and in control groups. Although the results were not similarly significant in every case, the capacity of the linoleic acid administrations in limiting the gastric mucose injury was evident. This protective capacity is not dependent on the lesive agent.

Animals

[60 cases of stenosis of the thoracic esophagus. Surgical technic].

Thoracic esophageal stenosis most frequently is seen in reflux disease as sequelae of endobrachyesophagus. In 10% of these cases later on an adenocarcinoma will be proven. Of special therapeutic interest in this field is the relationship with the Zollinger-Ellison syndrome, with scleroderma and with juvenile acid burns of the esophagus. As operative therapy in the benign state of reflux disease we advise conservative, organ-preserving, functional surgery with peroperative dilatation, abdominal fundoplication and, if necessary, vagotomy. Long-term follow-up results are demonstrated.

Adenocarcinoma

[Rectosigmoidovesical fistula].

The symptomatology of vesico-colonic fistulae is presented and their differential diagnosis discussed. Management should be tailored to the individual case. Whenever possible, we perform a radical primary operation. An additional by-pass colostomy is indicated if it is felt that the integrity of the anastomosis is jeopardised.

Colon, Sigmoid

[Does every hospital need a catastrophe plan?].

The organisation of any hospital to manage the medical supply in case of general disaster should guarantee the maximum effectiveness. The increase of output has to be realised on the emergency ward, OR, JCU and on the general wards. The planning should include the management, the competence and the coordination inside and outside the hospital.

Disaster Planning

[Reflux esophagitis: operative method in adults: fundoplication (author's transl)].

When the indications for fundoplication are correctly applied and followed, the standard anterior wall method has been proved both clinically and experimentally to be the best antireflux operation; it offers excellent immediate and long-term results. It is debatable whether it should be combined with a vagotomy when the peptic element is excessive, for while this approach is undisputed in the presence of an ulcerated draining path, it calls for important considerations in its manner of execution. Gastropexy alone is an inadequate solution in all its technical modifications: We reserve it as the operation of choice for cases of paraesophageal volvulus of the stomach.

Adult

[Indications and tactics in recurrent hiatal hernia].

The collective term "recurrent hiatus hernia" groups the pseudo-recurrent lesions after inappropriate surgery together with true recurrencies. An early recurrency can often be attributed to surgical technique, a late recurrency is usually biological in nature. The manifold pathophysiology of these cases is dominated by an intercurrent relux, dysphagia or paraoesophageal stomach volvulus. A decision to operate must, because of the important technical risks inherent, be made only after fully exhausting the conservative alternatives. The reoperation requires surgeon specially qualified for the task, with experience in thoraco-abdominal procedures. Approaches and alternative operating techniques are discussed with reference to personal experience from 56 cases.

Hernia, Diaphragmatic

[Achalasia of the oesophagus. Operative treatment by abdominal myotomy and fundoplication (author's transl)].

Achalasia is a neuromuscular functional disturbance with dystonia and dyscinesia of the entire tubular oesophagus of unknown aetiology characterised by loss of cardial opening reflex. In the usual functional state dysphagia and moderate stenosis are observed, but occasionally an organic form with marked mega-dolicho-oesophagus will develop. Therapeutically an attempt is made to reduce the hypertonus of the terminal oesophagus. In mild or moderate cases this may be achieved by dilatation alone. If conservative treatment fails or in severe forms an operative correction is mandatory, we advise preoperative dilatation together with an extramucous myotomy of the distal anterior oesophageal wall and a fundoplication to prevent the gastro-oesophageal reflux. This abdominal procedure demands great care but is not traumatising and ensures satisfactory early and late results even in patients with considerable surgical risks. Operative indication and technique in 63 cases are demonstrated.

Adolescent

[Azygoportal interruption, fundoplication and vagotomy in hemorrhagic esophageal varices].

A vascular interruption to the azygoportal zone, achieved by devascularisation about the cardia and a closed transmural ligation of the varices is described, which is combined with a simultaneous truncal vagotomy, pyloroplasty procedure and a fundoplication. This fourfold method combats the bleeding varices at several points: a direct disruption of vascular paths, haemodynamic control, reduced influence of peptic factors, the management of coincident ulcer pathology and the prevention of gastro-oesophageal reflux. The results from 5 patients are encouraging. This abdominal operation is swift, comparatively atraumatic and may be undertaken in emergency cases and in at-risk patients on an elective basis.

Cardia

[20 years in the management of reflux disease using fundoplication].

During the past twenty years fundoplication has found widespread propagation. Due to its effectiveness it is today the most often applied operative procedure of reflux-preventing surgery. As such the method must be reserved for clearly demonstrated reflux disease and its organic complications. False indication and incorrect technique have burdened results of such operations with unnecessary complications. The steps to a successful surgical reconstruction of the cardia are thus shown. In the future, the results of this surgical method will have to be improved more by correct indication instead of changing the surgical technique.

Esophagitis, Peptic

[Intrathoracic pancreatic cysts and fistulas].

Intrathoracic extension of inflammatory pancreatic diseases is a serious complication. In the course of an acute pancreatitis, a left-sided transdiaphragmatic pleural effusion and empyema most commonly occurs and is well known. Transhiatal pseudocysts into the mediastinum as well as fistula formation to the pleural cavity or bronchial system are less frequent although of great clinical importance. These diseases can lead to serious diagnostic errors and can cause complex therapeutic problems. A case is reported; the morbidity, lethality and complications are discussed on the basis of 34 cases reported in the literature.

Adolescent