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M Rostin

Publications and source records attributed to M Rostin.

32 records · Page 2Linked to original sources
PubMed1985

Naloxone reverses the effects of enalapril and enalaprilic acid on the pressor responses to afferent vagal stimulation.

The effects of intracisternal injection of enalapril (MK 421) or its bioactive form enalaprilic acid (MK 422) (0.075 mg/kg) on the pressor responses elicited by afferent stimulation of the vagus were investigated in the urethane-anaesthetized dog. The angiotensin converting enzyme inhibitors (ACEI)-induced decrease in the systolo-diastolic pressor responses to vagal stimulation was reversed by naloxone (0.1 mg/kg iv). These data support evidence for an additional central site of action of These data support evidence for an additional central site of action of ACEI and suggest the involvement of central opioid mechanisms in the hypotensive properties of ACEI.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed1985

[Role of the adrenal medulla in the effect of antihypertensive drugs].

Recent studies have suggested a role for adrenaline in the pathogenesis of essential hypertension. In the present study, the effects of several anti-hypertensive agents were compared in normal (plasma adrenaline concentration: 0.267 + 0.040 ng/ml) and adrenomedullectomised (plasma adrenaline concentration: 0.063 + 0.011 ng/ml; p less than 0.01) dogs. The hypotensive and tachycardic effects of phentolamine (1.5 mg/kg i.v.) or dihydralazine (1 mg/kg i.v.) were the same in the two groups of dogs. Verapamil (0.2 mg/kg i.v.)-induced hypotension was less pronounced in dogs without adrenal medulla. In these adrenomedullectomised dogs, clonidine (10 micrograms/kg i.v. or 1 microgram/kg i.c.) elicited tachycardia and its hypotensive properties were delayed. In dogs with neurogenic hypertension, the antihypertensive properties of propranolol (1 mg/kg i.v.) remained unchanged. These results show the importance of adrenal medulla in the antihypertensive action of clonidine, or verapamil. These agents (but not dihydralazine, propranolol or phentolamine) could reduce adrenaline secretion from the adrenal medulla.

Adrenal Medulla↗
PubMed1982

Comparative study of terfenadine in allergic skin of patients in France.

The results of a double-blind comparative study of a new antihistamine, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1- piperidinebutanol (terfenadine, RMI 9918, Triludan, Teldane, resp.), are presented. Carried out on a total of 136 patients, this multicentre investigation had three main objectives: Firstly to evaluate the efficacy of terfenadine in skin allergies; secondly to evaluate its tolerance; and finally, to compare its activity with the activity of clemastine or with placebo. The results obtained with terfenadine are comparable to those obtained with the reference product clemastine and show that terfenadine is similar in efficacy to that expected when antihistamine drugs are used for the treatment of general allergic manifestations of skin. With respect to patient tolerance, the results are in agreement with those of previous studies which have demonstrated that terfenadine is well tolerated and that its sedative effect is negligible.

Adolescent↗
PubMed1982

[Oculo-cutaneous tyrosinase-positive albinism].

In the present work, the authors discuss the participation of prostaglandins in inflammatory reaction due to U. V. light and the consequences of prostaglandins deficiency. A patient of algerian origin was observed: this 60 year old woman, exhibited an albinism thyrosinase positive and tolerated fairly well an exposure to the U. V. light despite her disease. For ten years she has presented face, neck and arms hyperkeratosis, for five years, arm actinic porokeratosis, and for two years back and face carcinomas. M. E. D. is higher than the standard value. The discussion is open on the fact that this M. E. D. rise might result from prostaglandins deficiency (PE E2 F2). Moreover prostaglandins deficiency increases epidermal multiplication and could account for hyperkeratosis and malignant change, especially so as the patient suffers from albinism and lives in a sunny country. The authors, besides, attempts to relate the other symptoms of this patient to the hypothetical deficiency of prostaglandins; absence of the melanosome maturation, delays in cicatrisation and perhaps immunity perturbations.

Aged↗
PubMedDate not supplied

[An intensive survey of drug surveillance in a medical admissions department].

An intensive survey of pharmacovigilance was carried out in a medical admission department over a 4-month period. Out of 2,017 admissions to hospital, 23 (1,1 p. 100) were motivated by adverse reactions to drugs. Questioning brought out allergy and multiple drug therapy as important factors. Lesions of the skin and mucosae predominated, notably after treatment with antibacterial and non-steroidal anti-inflammatory agents. The categories of drugs involved were, in decreasing order of frequency: cardiovascular (6/23), anti-bacterial (5/23), neuropsychiatric (4/23) and non-steroidal anti-inflammatory drugs (4/23). The fact that the patients had taken several products rendered evaluation difficult. Using imputability scales made it possible to reduce the cause-effect relationship in 26 p. 100 of the cases.

Admitting Department, Hospital↗
PubMedDate not supplied

[Extrapyramidal syndromes caused by flunarizine. Apropos of 6 cases].

The ability of flunarizine in inducing or worsening extrapyramidal symptoms is well documented. The relation with age or dose of such symptoms as their clinical characteristics remain controversial. We report 6 cases of extrapyramidal syndromes induced by flunarizine in five women and one man (mean age 71.5 +/- 5 years). The daily dose was 10 mg in five cases (as recommended by the marketing laboratory) and 20 mg in one patient. These observations allow to discuss the dose-dependent occurrence of this adverse reaction. In only three cases the reason for treatment was compatible with the official french indication. These side effects appeared after 7.0 +/- 1.6 months and disappeared after 2.2 +/- 0.5 months respectively. Flunarizine-induced extrapyramidal symptoms are mainly characterized by tremor (which was the main symptom in 4 cases and the only one in 2 cases).

Aged↗