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Biomedical subjects

M Rothkopf

Publications and source records attributed to M Rothkopf.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Urogenital tuberculosis within the scope of general tuberculosis situation. Ambulatory management and care].

On the basis of two differential graphs the development of the general situation concerning tuberculosis in the GDR for the years 1962 to 1976 is described. Particularly taken into consideration were the new cases of urogenital tuberculosis which were compared with the rates of new cases in other countries. A significantly higher morbidity of tuberculosis was found in members of certain risk groups (so-called "gesunde Befundträger" [healthy persons not yet suffering from tuberculosis]). Regulations of the law for prevention of and combat against tuberculosis, principles of the continued ambulant treatment and the importance of the dispensary care were discussed. The success of treatment in the Berlin district, especially in the combat against urogenital tuberculosis, which refer to a more than 12 years observation period, are traced back to a continuity of initial stay in an urological clinic in connection with special procedures, following continued ambulant treatment and final after-care.

Aftercare↗
PubMed1977

Animal experiments on the question of the renal toleration of the horse chestnut saponin aescin.

The possibility that aescin might have a nephrotoxic side effect has been investigated by clearance studies in kidneys of healthy rats and by toleration studies in rats with damaged kidneys. The effect of aescin, both free and albumin-bound, on renal tubular transport processes was studied in the model of the isolated, artificially perfused frog kidney. The rates at which different concentrations of aescin were bound to rat plasma proteins were determined in vitro. The clearance of i.v. aescin was 13% of creatinine clearance and 7% of p-aminohippurate (PAH) clearance; this rules out the tubular secretion of aescin. No deaths occurred among aminonucleoside-damaged rats given i.v. sodium aescinate 2.2 mg/kg, but rats damaged with mercuric chloride or uranyl nitrate had exactly the same mortality rate as those given 2.2 mg/kg i.v. of sodium aescinate alone. The rats received four injections in all of aescin 0.35 mg/kg i.v., given at intervals of two days. Aescin had no effect on renal damage caused by aminonucleoside, mercuric chloride or uranyl nitrate. Aescin concentrations of 0.2 mg/l and 2.0 mg/l in the perfusion fluid increased the excretion of Na+ and glucose by the frog kidney and reduced the reabsorption of both these substances. With a sodium aescinate concentration of 5 mg/l the production of urine ceased. When 1% (w/v) of albumin was added to the perfusion fluid, even sodium aescinate 5 mg/l had no effect on the tubular transport of Na+, glucose and water. The fact that about 50% of aescin was not bound to plasma protein in vitro suggests that some of the small amount of aescin in the glomerular filtrate is reabsorbed in the tubules.

Animals↗
PubMed1976

[New findings on the efficacy and mode of action of the horse chestnut saponin escin].

In order to complete previous results of the efficacy of the horse chestnut saponin escin, its activity was tested on two further models of inflammation: the rat serous peritonitis provoked by i.p. injection of formalin solution, and the rat serous pleurisy provoked by intrapleural injection of Evans Blue/carrageenan. The results showed escin to be an anti-exudative substance with regard to its exudation inhibitory effect determined by the reduction of exudative fluid. As to peritonitis the diminution of protein permeation into the abdominal cavity was determined: with increasing doses escin tended to prevent more efficiently the diffusion of small molecules than the permeation of large molecules. The hypothesis that escin has an effect on the vascular walls in the sense of a "sealing" effect on the capillaries was tested on the following model: the permeability of the plasma-lymph barrier of the hind leg of the rabbit was enhanced by injection of bradykinin. Escin antagonised the bradykinin effect dose-dependently determined by the depression of the raised lymph-flow by about 70%.

Animals↗
PubMed1975

Experiences based on the classification of bladder tumours according to the TNM system.

Since 1967 we employ the TNM system of the UICC for the classification of bladder tumours. Cystography, pelvic arteriography and lymphography were carried out for the classification. 393 patients were examined by means of the X-ray methods. 323 patients were classified according to the TNM system. The 'P' stage was stated in 134 patients. This group of patients enabled a control of the pre-therapeutical classification. We found extensive conformity between pre-operative and post-operative diagnoses. The methods of classification tested by us allow an exact diagnosis.

Carcinoma in Situ↗