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Biomedical subjects

M Rougier

Publications and source records attributed to M Rougier.

29 records · Page 2Linked to original sources
PubMed1982

[Intramandibular salivary inclusions and ectopia (author's transl)].

Intramandibular salivary inclusions and ectopia concern the main salivary glands. The most common takes the form of a regular well-defined lacunar appearance situated at the mandibular angle or molar region. This asymptomatic inclusions is in fact only the imprint of a lobule of the sub-mandibular gland on the mandible. More rarely, the parotid gland and sublingual gland may also be responsible for a lacunar radiological appearance in the mandible. By contrast, a few ectopic glandular lobules of the sublingual may be completely induced at the site of the mandibular symphsis. Salivary inclusions and ectopia thus result from two different aerio-pathogenic mechanisms.

Choristoma↗
PubMed1981

[Mucoepidermoid tumor of the mandible (author's transl)].

The diagnosis of a mucoepidermoid tumor of the mandible has been made by pathological examination. This asymptomatic tumor was discovered on a routine radiographic film. Our 44 years old male patient was treated by surgical means. We have found 62 cases in the literature; intra-osseous cases of mucoepidermoid tumor seem to be rather scarce. Let us recall the presence of salivary glands in the mandible, a possible explanation of the occurrence of intra-osseous glandular tumor.

Adult↗
PubMed1979

[Cowden's disease. A report on two cases in Swiss families (author's transl)].

Described by Lloyd and Dennis in 1963, Cowden's disease is a familial affection in which are found associated lesions of the buccopharyngeal mucosa (papillomatosis, papules, scrotal tongue), various types of skin lesions (verruciform keratotic papules, papilloma, lipoma, angioma, etc...), visceral manifestations usually related to lesions in the thyroid, breasts, or digestive tract (hamartoma or malignant tumors), and skeletal dysmorphism. The two patients were from different families, were aged 65 and 28 years, and had presented for consultation because of buccal mucous membrane papillomatosis, and in one case, hemorrhagic gingivitis. Cowden's disease was diagnosed from the clinical examination, past history, and investigations after hospital admission. The main value of the mucosal and cutaneous lesions is their diagnostic significance, enabling a synthesis of the multiple dispersed manifestations to be made, and a possible visceral tumor to be discovered in the early stages.

Adult↗
PubMed1979

[Stomatodynias].

Stomatodynies are functional manifestations often observed in anxious and depressive individuals, in the form of glosso-, cheilo-, uranodynia. It may show itself in disturbances of the mucosa or of salivary secretion. It is necessary to reassure the patients, to explain the nature of the disease and to prevent them from autotherapy of local or psychic factors.

Diagnosis, Differential↗
PubMed1979

[Cowden disease: report of 8 cases in 2 families (author's transl)].

These 8 cases of multiple hamartoma syndrome are the first reported in Switzerland. Two men aged respectively of 65 and 28 years presented a cobblestone appearance of the gingiva and of the tongue ("pebbly tongue"), which suggested Cowden disease. This diagnosis was confirmed by the discovery of numberous skin lesions, a thyroid goiter, gastrointestinal polyposis, and a mild skelettal dysmorphosis. The older patient had a grade one carcinoma of the bladder; his son and his daughter presented the syndrome, which was also discovered in the family of the second patient (his father, his brother, his sister and one of her daughters). The ultrastructural study of two skin biopsies demonstrated anomalies of the fibroblasts and collagen fibers.

Adolescent↗
PubMed1976

[Perparation and comparative analytical study of cat liver microsomes].

Cat liver homogenates have been fractionated by differential centrifugation. Four particulate fractions (1 000 X g, 10 000 X g, and 145 000 X g) and a supernatant have been obtained. The biochemical composition of these fractions has been established from the assay and distribution pattern of 22 enzymatic and chemical constituents including marker enzymes for mitochondria, lysosomes, peroxisomes, plasma membranes, endoplasmic reticulum, Golgi apparatus and cell sap. The microsomal fraction was characterized by a moderate contamination with large cytoplasmic granules and by a low yield in protein and cholesterol. It contained 50 per cent of Golgi complex and about 40 per cent of plasma membranes. Morphological analysis of subcellular fractions was performed and confirmed biochemical results.

Animals↗
PubMedDate not supplied

[Citalopram. An open study of a highly selective serotonin-uptake inhibitor administered by infusion to depressive patients].

In an open, clinical trial comprising a total of 49 depressed in-patients, a new selective 5-HT uptake inhibitor citalopram was administered by intravenous infusion in doses of 20-60 mg once daily for per 3 weeks. The therapeutic effect was assessed globally and by means of the CPRS subscale for depression (MADRS). About 40 per cent of the patients showed a complete response whereas about 25 per cent showed a partial response. Side effects which were rated globally and recorded according to a check-list were generally mild and infrequent. The side-effects most frequently observed were tremor, drowsiness, and dizziness which occurred in about 15 per cent of the patients.' Three patients were withdrawn prematurely because of nausea and one because of a skin rash. Cardiovascular recordings were normal except for one patient, who developed a hypertension which may have been related to the test drug. No pathological laboratory values were detected during the trial period. The authors conclude that intravenously administered citalopram is well suited for the treatment of depressed patients.

Adult↗