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Biomedical subjects

M Rozmus

Publications and source records attributed to M Rozmus.

17 recordsLinked to original sources
PubMed1984

[Determination of the concentration of chorionic gonadotropin (HCG) and its free subunits in placental tissue during various periods of normal pregnancy].

The aim of this study was to estimate HCG and its free subunits (alpha and beta) content in placental tissue and to determine the characteristic pattern of their ratio changes in the course of normal pregnancy. For this we used 47 samples of placental extracts. The tissue was extracted and gel filtrated on a calibrated Sephadex-G-100 column. Crude placental extracts and each fraction after chromatography were radioimmunoassayed for HCG, alpha HCG and beta HCG in a double antibody, homologous radioimmunoassay system. We obtained the following results: Peak of native HCG secretion occurred in 6-8 gestational week thereafter its concentration in placenta decreases. The absolute amount of free alpha HCG increased after the first trimester like to native HCG, but the relative quantity of alpha HCG exceeded that for HCG. In extracts from mature placenta quantity of free alpha HCG was about 5-10-fold more than HCG. In chorionic extracts from the first trimester we have proved the free beta subunit of HCG. It has not been found in extracts from mature placenta.

Chorionic Gonadotropin↗
PubMed1980

[Role of detection of alphafoetoprotein in serum of pregnant women with risk of abortion (author's transl)].

Alpha, foetoprotein (AFP) was radio-immunologically determined in the serum of 109 pregnant women with imminent abortion and of 220 clinically intact women who were between the sixth and 22nd weeks of pregnancy. -- AFP values were found to be normal, within limits between 0.5 m and 2.0 m, in 84.8 per cent of the clinically intact women and in 83.3 per cent of those pregnant women with imminent abortion and favourable completion of pregnancy. Values were above or below normal in 73.3 per cent of those pregnant women who failed to complete pregnancy with good success.

Abortion, Spontaneous↗